Author(s): S. Venkateswara Rao, D. Bhagya Sri Vani, K. Padmalatha

Email(s): venkateshsadhu@gmail.com

DOI: 10.5958/0974-360X.2021.00296.1   

Address: S. Venkateswara Rao1, D. Bhagya Sri Vani1*, K. Padmalatha2
1Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada – 521108, India.
2Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada–521108, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
Aim and Objective: The aim of the study was to develop Flutamide loaded chitosan - sodium tripolyphosphate (STPP) nanoparticles using Ionic gelation method and characterization of their physicochemical properties and in-vitro release studies. The objective was to fabricate chitosan based nanoparticles for better controlled and targeting action of drug, which also overcome the problems associated with conventional formulations like multidose therapy, poor patient compliance and high cost. Materials and Methods: Flutamide loaded chitosan nanoparticles (F1 to F6) were prepared by Ionotropic gelation method. The formulated nanoparticles were evaluated for external morphological characters, particle size analysis, zeta potential, drug content, entrapment efficiency and in-vitro release studies. Results: The particle size varied from 148 to 317nm and zeta potential was in negative and its value found to be - 46.4mV. The drug content for the Flutamide loaded chitosan nanoparticles varied from 69.5±7.2% to 87.9±1.2%. The entrapment efficiencies were found to be minimum and maximum of 55.50±2.4% and 86.30±3.6%. The percentage yields of all formulations were in the range of 48.24 ±1.24 to 86.13±1.37%. In-vitro release of drug showed sustained release behaviour for a period of 24 hr. Conclusion: The optimized formulation contains 3:1 ratio of chitosan and STTP and demonstrated successful sustained release. Flutamide loaded chitosan nanoparticle is a potential new delivery system for treatment of prostate cancer.


Cite this article:
S. Venkateswara Rao, D. Bhagya Sri Vani, K. Padmalatha. Development and Characterization of Chitosan based flutamide Nanoparticles by Ionic Gelation Method. Research J. Pharm. and Tech 2021; 14(3):1668-1672. doi: 10.5958/0974-360X.2021.00296.1


REFERENCES:
1.    Goldspiel BR, Kohler DR. Flutamide: an antiandrogen for advanced prostate cancer. DICP. 1990; 24: 616–623.
2.    Elgindy N, Elkhodairy K, Molokhia A, Elzoghby A. Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug. flutamide. Eur J Pharm Biopharm. 2010; 74: 397–405.
3.    K. Umasankar and C. Umamaheswar Reddy. Nanoparticular Drug Delivery System of Anticancer Drug – Flutamide. International Journal of Pharm Tech Research. 2010; Vol. 4; 1115.
4.    Adlin Jino Nesalin J, Gowthamarajan K and Somashekhara C.N. Formulation and evaluation of nanoparticles containing flutamide. International Journal of Chem Tech Research. 2009; Vol. 1; 1331 – 1334.
5.    Dipsingh SN. Preparation and in vitro–in vivo evaluation of surface-modified poly(lactide-coglycolide) nanoparticles as controlled release carriers for flutamide delivery. Journal of Microencapsulation. 2015; Vol. 32; 231–239.

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