Vishnu Prasad Yadav, Rajeev Kumar, Vijay Bahadur Maurya
Vishnu Prasad Yadav1, Rajeev Kumar2, Vijay Bahadur Maurya3*
1Assistant Professor, Government Polytechnic, Jaunpur, U.P. (India).
2Assistant Professor, Institute of Pharmacy, V.B.S. Purvanchal University, Jaunpur, U.P. (India).
3Assistant Professor, Institute of Pharmacy, V.B.S. Purvanchal University, Jaunpur, U.P. (India).
Volume - 14,
Issue - 3,
Year - 2021
The ethanolic leaves extract of P.deltoides was tested for the presence of various phytoconstituents using standard procedure and study was designed to evaluate the anti-inflammatory activity in rodents. Anti-Inflammatory activity of leaves extract of P.deltoides (250 and 500mg/kg) was studied in carragenin induced paw edema and cotton pellet granuloma in rat. The ethanolic leaves extract of plant revealed the presence of variety of chemical constituents like terpenoids, alkaloids, flavonoids, tannins, saponins, amino acids and glycosides. Leaves extract of P.deltoides significantly showed anti-Inflammatory activity in carrageenin induced paw edema by reducing paw volume in rats. From our study we concluded that leaves extract of P.deltoides has potential to anti-inflammatory and suggests that it can be used in the management of inflammation, thus providing a scientific basis for its traditional use.
Cite this article:
Vishnu Prasad Yadav, Rajeev Kumar, Vijay Bahadur Maurya. Evaluation of Anti-inflammatory Activity of Ethanolic Extract of Populus deltoides. Research J. Pharm. and Tech. 2021; 14(3):1645-1650. doi: 10.5958/0974-360X.2021.00292.4
1- Chen L, Deng H, Gui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L, Inflammatory response and inflammatory associated disease in organs, Oncotarget, 2018, 9(6):204-228
2- Cronkite D A, Struff T M, The regulation of inflammation by innate and adoptive lymphocytes, Journal of Immunology Research, 2008, 1-14
3- Huang J, Cai X, Ou Y, Zhou Y, Wang Y, Resolution of inflammation in periodontitis, a review, Int. J. Clin. Exp. Pathol, 2018, 11 (9), 4283- 4295
4- Stankov S V, Definition of inflammation, causes of inflammation and possible anti- inflammatory stretegies, The Open Inflammation Journal, 2012, 5,1-9
5- Adams J M, Difazio L T, Rolandelli R H, Lujan L L, Hasko G Y, Csoka B, Selmeczy Z S, Nemeth Z N, HIF-1: a key mediator in hypoxia, Acta Physiologica Hungarica, 2009,96 (1), 19-28
6- Krishnkumar N, Palanisamy K, Hegde M, Warrier K C S, Krishnamoorthy M., Manual of Economically Important Forestry Spesies in South India, Institute of Forest Genetics and Tree Breeding, 2010, 362-372,
7- Khan F A, Khan M F, Inflammation and acute phase response, Internationl Journal of Applied Biology and Pharmceutical Technology, 2010, (1), 312-321
8- Wakefield D, Kumar R K, Inflammation: chronic, Encyclopedia of Life Science, 2001, 1-6
9- Gul R, Sayed U, Sayed F, Sherani S, Jahan N, Preliminary Phytochemical Screening, Quantitative Analysis of Alkaloid and Antioxident Activity of Crude Plant Extract form Ephedra Intermedia Indegenous to Balochistan, The Scientific World Journal, 2017, 1-7
10- Auwal M S, Saka S, Mairiga I, Sanda K A, Shuaibu A, Ibrahim A, Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extract of acacia nilotica, Veterinary Research Forum, 2014, 5(2), 95-100
11- Farooq U, Waseem B, Muzaffar R, Tripathi J, Tharani M, Sharma M, A comparative study of Phytochemical investigation of xanthium strumarium medicinal plant, International Journal of Research in Pharmacy and Chemistry, 2014, (1), 96-100
12- Kodangla C, Saha S, Kodangla P, Phytochemical Studies of Areial Parts of the plant Leucas Lavendulaefolia, Der Pharma Chemica, 2010, 2(5),434-437
13- Vimal K C S, Hosagaudar V B, Suja S R, Vilash V, krishnakumar N M, Latha P G, Comparative preliminary phytochemical analysis of ethanolic extract of leaves of olea dioica roxb infected with the rust fungus zaghauania oleae cummins and non-infected plant, Journal of Pharmacognosy and Phytochemistry, 2014,3(4), 69-72
14- Sheel R, Kumari N, Kumar J, Preliminary phytochemical screening of methonolic extract of clerodendron infortunatum, IOSR Journal of Applied Chemistry, 2014, 10-13
15- Mir M A, Parihar K, tabasum U, Kumari F, Journal of medicinal plants, estimation of alkaloid, saponin and flavonoid content in various extract of Crocus sativa, 2016, 4(5), 171-174
16- Panchal P, Parvez N, Phytochemical analysis of medicinal herb ocimum sanctum, International Journal of Nanomaterial, Nanotechnology and Nanomedicine, 2019, 8-11
17- Gaddaguti V, Reddy S, Bhogireddy N R, Venkat B, Talluri V R, Rao A P, Pharmacognostic and preliminary phytochemical evaluationof Oscimum basilium L. var P losum (wild) benth and o. tenuiflorum var CIM-AMY, International Journal of Pharmacognosy and Phytochemical Research, 2015, 7(3), 519-526
18- Gul R, Jan S U, Faridullah S, Sherani S, Preliminary phytochemical screening, quantitative analysis of alkaloids and antioxidents activity of crude plant extract from ephedra intermedia indigenous to Balochistan, The Scientific World Journal, 2017, 1-7
19- Liji K O, Vasudevan C N S, Comperative pharmacognostic and phytochemical studies of ocimum tenuiflorum l and its substitute in vitex negundo, International Journal of Ayurveda and Pharma Research, 2017, 9-19
20- Mondal S, Ghosh D, Ganpaty S, Manna O, Reddy M V, Ravanth V, Evaluation of analgesic, antipyretic and anti-inflammatory effect of ethanol extract from a fern species macrothelypterus torresiania aerial parts, Pharmacognosy Communication, 2016, 6, 57-63
21- Sawadogo W R, Boly R, Lompo M, Some N, Anti-inflammatory, analgesic and anti-pyretic activity of Dicliptera verticillata, International Journal of Pharmacology, 2006, 2(4), 435-438
22- Sireegata W S, Itharat A, Lerdvuthisopon N, Piyabhan P, Khonsung P, Boonraeng S, Jaijoy K, Anti-inflammatory, analgesic and antipyretic activity of ethanol extract of Piper interuptum opiz and Piper choba linn, International Scholarly Research Network, 2012,1-6