Author(s): A. Bharathi, D. Chandra Sekhar Naik


DOI: 10.5958/0974-360X.2021.00291.2   

Address: A. Bharathi, D. Chandra Sekhar Naik
K.V.S.R Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada, A.P, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021

Starch Glutarate prepared by reacting potato starch with Glutaric acid at elevated temperatures was found to be a white, crystalline powder. Starch glutarate prepared exhibited excellent flow characteristics it was insoluble in water and aqueous fluids of acidic and alkaline buffers. It also exhibited good swelling (70%) in water. It has no gelling property when heated at 100Co in water for 30 min. It is considered as a promising disintegrant in tablet formulations and was evaluated as disintegrant in tablet formulations. Tablets of Telmisartan were prepared by direct compression method employing starch glutarate at 0-10% as novel super disintegrate and were evaluated. In the present research work, 23 factorial design was used for optimization of level of independent variables (starch glutarate, sodium starch glycolate and croscarmellose sodium) on dependent variables (disintegration time, water absorption, wetting time and percent released in 5 minutes) in the formulations. The optimized formula was further press coated by synthetic controlled time released polymers such as starch acetate, starch succinate in varying ratios. The best formulation was selected based on post-compression parameters and dissolution data was subjected to accelerated stability studies for 3 month. Amongst 5 formulations prepared for coating tablets we are F2CC1 produced convincing results with a maximum cumulative drug release of 99.21%. in 8 hr. By virtue of its release pattern and delivering the drug at the right time, right place and in right amounts, the developed delivery system holds good promises of benefiting the patients suffering from hypertension.

Cite this article:
A. Bharathi, D. Chandra Sekhar Naik. Design, Optimization and Evaluation of Telmisartan Chronotherapeutics press coated tablets Employing as Novel synthetic Disintegrate and as Novel coated Chronotherapeutic Polymers. Research J. Pharm. and Tech 2021; 14(3):1639-1644. doi: 10.5958/0974-360X.2021.00291.2

1.    P Wal, A Wal, A K Rai, A Saxena. Journal of Pharmaceutical Science and Technology. 2009; 1(2):59-62.
2.    A B Rane, S G Gattani, V D Kadam, A R Tekade. Chem. Pharm. Bull. 2009; 57(11): 1213-1217.
3.    S S Shidhaye, V M Lotlikar, P K Phuthane, V J Kadam. Pulsatile drug delivery is time and site-specific drug deliver, Systematic. Reviews in Pharmacy. 2010; 1(1):55-61.
4.    L Prisant. Research profile on Biomed Experts. Clinical Cornerstone. 2004; 6(4): 7-15.
5.    L M Prisant. Assessment of sequential same arm agreement of blood pressure measurements. The American Journal of Hypertension. 2001; 14: 277S–279S.
6.    V S Belgamwar, M V Gaikwad, G B Patil, S Surana. Pulsatile drug delivery systems. Asian Journal of Pharmaceutics. 2008; 2(3): 141-145.
7.    A K Anal. Prevalence and Antimicrobial Drug Resistance. Recent Patents on Drug Delivery and Formulation. 2007; 1: 73-79.
8.    J Cooper, C Gunn. Powder flow and compaction, Tutorial Pharmacy, New Delhi India, CBS Publishers and Distributors. 1986; 211-233.
9.    M E Aulton, T I Wells. Pharmaceutics: The science of dosage form Design, London, England, Churchill Livingstone.1988; 133-135.
10.    Indian Pharmacopoeia, New Delhi, Ministry of Health and Family Welfare, Government of India, Controller of Publications, 2007; II: 662-665.
11.    L Lachman, H A Liberman, J L Kanig. The Theory and Practice of Industrial Pharmacy, Mumbai, India. Varghese Publishing House.1999; 3: 297-299.
12.    Manivannan R, Sriram V, Rao BLN and Reddy PVK: Formulation and evaluation of Metformin hydrochloride sustained release tablets. International Journal of Biopharmaceutics. 2013; 4(2): 73-79.
13.    Sravani B, Deveswaran R, Bharath S, Basavaraj BV and Madhavan V: Development of sustained-release metformin hydrochloride tablets using a natural polysaccharide. International Journal of Applied Pharmaceutics. 2012; 4(2): 23-29.
14.    Fukui S, Yano H, Yada S, Mikkaichi T and Minami H: Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropyl cellulose. Asian Journal of Pharmaceutical Sciences. 2016; 11(2): 1-20.
15.    Elzayat EM, Abdel-Rahman AA, Ahmed SM, Alanazi FK, Habib WA, Abou-Auda HS and Sakr A: Formulation and pharmacokinetics of multilayered matrix tablets: Biphasic delivery of diclofenac. Saudi Pharmaceutical Journal. 2017; 25: 688-95.

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