Author(s): Balamurugan K, Sathya B, Anbazhagan S


DOI: 10.5958/0974-360X.2021.00290.0   

Address: Balamurugan K1*, Sathya B1, Anbazhagan S2
1Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram - 608002, Tamilnadu, India.
2Department of Pharmaceutical Chemistry, Surya School of Pharmacy, Vikravandi - 605652, Villupuram, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021

The current study was aimed to investigate the antidepressant-like activity of Diosgenin and Silymarin in combination against depression using phenobarbitone-induced sleeping time in rats. The study was carried out in four groups of wistar rats (150 – 200gm) of either sex containing six animals each. Group I was served as a control (0.5 % CMC, 10ml/kg, p.o.). Groups II, III and IV were treated with Diosgenin (100mg/kg, p.o.), Silymarin (100mg/kg, p.o.) and combination of Diosgenin (50mg/kg, p.o.) + Silymarin (50mg/kg, p.o.), respectively. For the phenobarbitone-induced sleeping test, rats were pre-treated with the standard and the test drugs 30 minutes prior to the administration of phenobarbitone sodium (40mg/kg, body weight, i.p.). The parameters like onset of sleep and duration of sleep was recorded on each animal. Diosgenin and Silymarin, given at a dose of 100mg/kg, each, shown significant decrease in duration of sleeping time in rats with P value less than 0.05, compared with control group of animals. The same two bioactive compounds when given in combination (50mg/kg, p.o., each), shown significant antidepressant-like effect, potentially. The result concluded that, the bioactive compounds, Diosgenin and Silymarin, in combination could exert a synergistic antidepressant-like action on phenobarbitone-induced sleeping time in rats.

Cite this article:
Balamurugan K, Sathya B, Anbazhagan S. Enhanced Antidepressant-Like Activity of Diosgenin and Silymarin in Combination on Phenobarbitone-Induced Sleeping Time in Rats. Research J. Pharm. and Tech 2021; 14(3):1635-1638. doi: 10.5958/0974-360X.2021.00290.0

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