Author(s): Pravalika L, Shravan Kumar Y.

Email(s): lakkam.pravalika@gmail.com , shravanyamsani@gmail.com

DOI: 10.5958/0974-360X.2021.00284.5   

Address: Pravalika L, Shravan Kumar Y.*
Vaagdevi College of Pharmacy, Affiliated by: Kakatiya University.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
Theophylline hard candies lozenges were prepared to provide slow release of medicament for the treatment of wheezing, shortness of breath, and breathing problems caused by asthma. It makes breathing easier by relaxing and opening air passage in the lungs. There are several dose forms like syrups, tablets, ODT`s offered within the market however still there's would like for brand new dose forms that acts effectively and domestically for paediatric and people with difficulty in swallowing. The local acting mechanism of theophylline makes it more suitable to formulate as lozenges. The hard candy lozenges were formulated using sugar as a base Locust Bean gum, Kondagogu gum and Neem gum are used as natural polymers. The usage of corn syrup in the formulation made the lozenges smooth which helped in improving the elegance of the formulation. Stevia was used as sweetener. Sweeteners along with flavours are used to mask bitter taste of drug. The formulation of hard Candy lozenges was subjected to physico-chemical as well as in vitro drug release. Among all the formulations of hard candy lozenges F10 had shown in vitro drug release of 98.9% at the end of 30 minutes.


Cite this article:
Pravalika L, Shravan Kumar Y. Formulation and Evaluation of Theophylline Lozenges. Research J. Pharm. and Tech 2021; 14(3):1601-1606. doi: 10.5958/0974-360X.2021.00284.5

Cite(Electronic):
Pravalika L, Shravan Kumar Y. Formulation and Evaluation of Theophylline Lozenges. Research J. Pharm. and Tech 2021; 14(3):1601-1606. doi: 10.5958/0974-360X.2021.00284.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-3-73


REFERENCE:
1.    Srikanth P, MadhusudanRao Y, Shravan Kumar Y. Formulation and evaluation of levodropropizine lozenges. World Journal of Pharmaceutical Research. 2015; 4: 646-659.
2.    MadhusudanRao Y, Shravan Kumar Y, Sandeep P, Naresh N. Formulation and evaluation of lidocaine lozenges. International Journal of Innovative Research in Science Engineering and Technology. 2015; 4(11): 11640-11647.
3.    Chandrawanshi Mayuri J, Sakhare R S, Dr. Nagoba Shivappa N, and Bhalekar Rohini V. A review on medicated lozenges. World Journal of Pharmaceuticals Research. 2019; 8(2): 396-412.
4.    Khaladkar A, Avalaskar A, Bharati P, and Honkalas K. Formulation and evaluation of Adhulsa lozenges for pediatric patients. J Drug Del Thera. 2019; 9(2-s): 115-117.
5.    Michael Lee Martin. Medicated Hard Candy Product for Treating Oesophageal Inflammation and A Method Using the Same. 2019; US20190060226A1.
6.    Renuka P, Shayeda Y, Madhusudan Rao. Development and in-vitro evaluation of nicotine hard candy lozenges for smoking cessation. Int J Pharm Pharm Sci, 2014; 6(3): 625-629.
7.    Kothagattu Nandini, Arsham Priyadarshini, Shravan Kumar Yamsani. Formulation and evaluation of Doxofylline lozenges. Cur trends Biotech Pharm. 2018; 12(1): 43-52.
8.    Rao TV, Suma K, Sahitya K, Leelarani A, Achireddy A, Sreenubabu P, Bhadramma N. Design and Development of Tramadol Hydrochloride Lozenges for Pediatrics. Res J Pharma Dosage Forms Tech. 2018; 10(3): 157-16.
9.    Yan Zhaoxia, Su Hongmei. Lithocarpus litseifolius lozenges and preparation method. 2018; CN108541948A.
10.    James N, BeMiller. Guar, Locust Bean, Tara, and Cassia Gums. Carbo Chem Food Scie. 2019; III.
11.    Abayomi T, Ogunjimi, Gbenga Alebiowu. Material and tableting properties of Azadirachta indica gum with reference to official acacia gum. 2014; 71: 107-118.
12.    Jaspreet Singh, Balwinder Singh. Gum Kondagogu – A Natural Exudate from Cochlospermum gossypium. The Botanica. 2013; 62-63: 115-123.

Recomonded Articles:

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG

DOI: Not Available         Access: Open Access Read More

Author(s): Anupam Roy, Biswajit Das

DOI: 10.5958/0974-360X.2015.00237.1         Access: Open Access Read More

Author(s): Vijay Simha G.1, Meena Ajay Kumar1, Sannd Rajesh1, Panda P.2 and M.M. Rao3

DOI: Not Available         Access: Open Access Read More

Author(s): S Hemalatha and M Jegadeesan

DOI: Not Available         Access: Closed Access Read More

Author(s): Sumit Yadav, Kawtikwar PS, Sakarkar DM, Gholse YN, Ghajbhiye SD

DOI:         Access: Open Access Read More

Author(s): Akansha Bhandarkar, Amit Alexander, Aditi Bhatt, Pankaj Sahu, Palak Agrawal, Tripti Banjare, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Siddharth Kumar Sahu, Pooja Yadav, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Vinay Sagar Verma, Mukesh Sharma, D. K. Tripathi, Ajazuddin

DOI: 10.5958/0974-360X.2018.00243.3         Access: Open Access Read More

Author(s): Ravi Kumar, Jismon Jose, Mahin M.M., Rahul Raut, Shantesh Masurkar, Narayana Swamy V.B.

DOI: Not Available         Access: Open Access Read More

Author(s): Sushil J. Pawar, Santosh Y. Nandedkar, Rajendra D. Wagh, Tanvir Shaikh, Vaibhav Jagtap

DOI: Not Available         Access: Open Access Read More

Author(s): P.K. Upadhyay, Vikas Kumar Jain, Kavita Sharma, Ravi Sharma

DOI: 10.5958/0974-360X.2020.00297.8         Access: Open Access Read More

Author(s): Nishita Singh, Arun Tiwari, Roohi Kesharwani, Dilip K. Patel

DOI: 10.5958/0974-360X.2016.00188.8         Access: Open Access Read More

Author(s): Tom Damien, Someshwara Rao B., Ashok Kumar P., Amith S. Yadav, Suresh V. Kuikarni

DOI:         Access: Open Access Read More

Author(s): Shinde Sunita S., Amol S. Shete, Patil Manisha V., J.I. Disouza

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags