Author(s): Santosh Karajgi, Shripad Potadar

Email(s): santosh.karajgi@gmail.com

DOI: 10.5958/0974-360X.2021.00278.X   

Address: Santosh Karajgi, Shripad Potadar
Department of Pharmaceutical Quality Assurance, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur 586103.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
A study on the hydrotropic solubility and linearity profile of Apixaban was carried out by using Sodium Salicylate as the solubilizing agent as Apixaban is poorly soluble in water. Apixaban was freely soluble in water when 1.5M Sodium Salicylate was used as a solubilizing agent. Apixaban shows an absorption maximum at 318nm in First derivative mode of measurement using Shimadzu UV Spectrophotometer 1800 Spectronic model. At this absorption maximum of 318nm, Apixaban shows a linear response in the range of 2µg/ml to 14µg/ml concentration. The present study is useful for the aqueous solubilization and quantitative determination of Apixaban in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.


Cite this article:
Santosh Karajgi, Shripad Potadar. Hydrotropic Solubilization and Linearity Profile of Apixaban. Research J. Pharm. and Tech 2021; 14(3):1576-1578. doi: 10.5958/0974-360X.2021.00278.X


REFERENCES:
1.    Maheshwari, R.K. and Moondra S. A novel method for the quantitative determination of Aceclofenac in bulk drug and tablet using Sodium Salicylate as a hydrotropic solubilizing agent. J. Adv. Pharm. Tech. Res., 2010, 1(1), 78-82.
2.    Ji Young Kim, Sungwon Kim, Michelle Papp, Kinam Park, Rodolfo Pinal et al. Hydrotropic solubilization of poorly water soluble drugs. J. Pharm. Sci., 2010, 99(9), 3953-3965.
3.    https://www.epa.gov/ [U.S. Environmental Protection Agency, accessed on 27th February 2020
4.    https://www.ich.org/page/quality-guidelines [ICH, accessed on 27th February 2020].
5.    https://www.fda.gov/media/71021/download [USFDA, accessed on 27th February 2020].

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