Author(s): Ramesh R. Pawar, Sandip B. Nahire


DOI: 10.5958/0974-360X.2021.00218.3   

Address: Ramesh R. Pawar, Sandip B. Nahire*
Department of Chemistry, M.S.G. College, Malegaon (M.S.) India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021

The measurement of solubilities of malonic acid in water, methanol, ethanol, water + methanol and water + ethanol binary solvent mixtures were carried out over the entire composition range between 0 to 1 weight fraction of methanol and ethanol at (293.15, 295.15, 298.15, 300.15, 303.15, 305.15, 308.15, and 313.15) K. The experimental solubility data were correlated by using Apelblat and van’t Hoff equation. These equations provide better correlation in these measurements. DFT was carried out to correlate solubility in various solvents system. Thermodynamic parameters (?H_soln^0,? ?S?_soln^0, ??G?_soln^0, %?H, %?TS) of solution were calculated using van’t Hoff equation.

Cite this article:
Ramesh R. Pawar, Sandip B. Nahire. Investigation, Correlation and DFT study for solubility of Malonic acid in water + methanol and water + ethanol binary solvents at T = 293.15 to 313.15 K. Research J. Pharm. and Tech. 2021; 14(3):1226-1232. doi: 10.5958/0974-360X.2021.00218.3

1.    Hildbrand, S.; Pollak, P. Malonic Acid and Derivatives. March 15, 2001. Ullmann's Encyclopedia of Industrial Chemistry.
2.    Lu J., Wang X.J., Yang X., Ching C.B., Solubilities of Glycine and Its Oligopeptides in Aqueous Solutions, J. Chem. Eng. Data 51 (2006) 1593–1596.
3.    Singrey, S. L.; Thomas, S. C.  U.S. Patent 3,338,959, August 29, 1967.
4.    Pawar, R. R.; Nahire, S. B.; Hasan, M. Solubility and Density of Potassium Iodide in Binary Ethanol-Water Solvent Mixture at (298.15, 303.15, 308.15, and 313.15) K J. Chem. Eng. Data, 54, 1935−37 (2009).
5.    Pawar, R. R.; Golait, S. M.; Hasan, M; Sawant, A. B.  Solubility and Density of Potassium Iodide in a Binary Propan-1-ol−Water Solvent Mixture at (298.15, 303.15, 308.15, and 313.15) K J. Chem. Eng. Data. 55, 1314−16 (2010).
6.    Pawar, R. R.; Aher C.S.; Pagar J. D.; Nikam S.L.; Hasan, M.  Solubility, Density and Solution Thermodynamics of NaI in Different Pure Solvents and Binary Mixtures J. Chem. Eng. Data. 57, 3563−3572, (2012)
7.    Frisch M J, et al. Gaussian 03, Rev. E. 01, Gaussian Inc, Wallingford, CT, 2004.
8.    Lee C, Yang W, Parr R. Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density Phys. Rev. B., 1988; 37: 785.
9.    Zhu P, Chen Y, Fang J, Solubility and solution thermodynamics of thymol in six pure organic solvents J. Chem. Thermodynamics, 92, 2016, 198-206
10.    Apelblat A and Manzurola E.  Solubility of oxalic, malonic, succinic, adipic, maleic, malic, citric, and tartaric acids in water from 278.15 to 338.15 K J. Chem. Thermodynamics 1987, 19, 317-320.
11.    Ruidiaz M A, Delgado D R, Martínez F Y. Marcus Solubility and preferential solvation of indomethacin in 1,4-dioxane + water solvent mixtures Fluid Phase Equilib., 2010; 299: 259–265.
12.    Hildebrand J H, Prausnitz J M, Scott R L. Regular and Related Solutions, Van Nostrand Reinhold, New York, 1970.
13.    Manrique Y. J., Pacheco D. P. Martínez F, Thermodynamics of Mixing and Solvation of Ibuprofen and Naproxen in Propylene Glycol + Water Cosolvent Mixtures J. Solut. Chem. 37 (2008) 165–181.
14.    Aragón D. M., Sosnik A., Martínez F., Solution Thermodynamics of Triclocarban in Organic Solvents of Different Hydrogen Bonding Capability J. Solut. Chem. 38 (2009) 1493–1503.
15.    Neau S. H., Flynn G. L., Solid and Liquid Heat Capacities of n-Alkyl Para-aminobenzoates Near the Melting Point. Pharm. Res. 7 (1990) 1157–1162.
16.    Ruidiaz M. A., Delgado D. R., Martínez F., Marcus Y., Solubility and preferential solvation of indomethacin in 1,4-dioxane + water solvent mixtures   Fluid Phase Equilib. 299 (2010) 259–265.
17.    Wilhoit, R.C.; Shiao, D., Thermochemistry of Biologically Important Compounds. Heats of Combustion of Solid Organic Acids.  J. Chem. Eng. Data, 1964, 9, 595.
18.    Hansen, Anne R.; Beyer, Keith D., Experimentally Determined Thermochemical Properties of the Malonic Acid/Water System:  Implications for Atmospheric Aerosols J. Phys. Chem. A, 2004, 108, 16, 3457-3466,
19.    Apelblat A, Manzurola E.  Solubilities ofo-acetylsalicylic, 4-aminosalicylic, 3, 5-dinitrosalicylic, andp-toluic acid, and magnesium-DL-aspartate in water from T=(278 to 348) K J. Chem. Thermodyn., 1999; 31: 85–91.
20.    Yang Z H, Shao D F, Zhou G Q. Solubility parameter of lenalidomide for predicting the type of solubility profile and application of thermodynamic model J. Chem. Thermodyn., 2019; 132: 268–275.
21.    Yu Y, Zhang F, Gao X Q, Xu L, Liu G, J.  Experiment, correlation and molecular simulation for solubility of 4-methylphthalic anhydride in different organic solvents from T = (278.15 to 318.15) K J. Mol. Liq., 2019; 275: 768–777.
22.    Shakeel F, Haq N, Alanazi F K, Alsarra I A. Solubility and thermodynamics of apremilast in different mono solvents: Determination, correlation and molecular interactions Int. J. Pharm., 2017; 523: 410–417.
23.    Zhao W, Yang W, Hao J. Determination and Thermodynamic Modeling of Solid–Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol + Ethyl Acetate) Binary Solvent Mixtures J. Chem. Eng. Data, 2017; 62: 1965-1972.
24.    Kim K H, Oh H K, et al. Solubility evaluation and thermodynamic modeling of β-lapachone in water and ten organic solvents at different temperatures Fluid Phase Equil., 2018; 472: 1-8.
25.    Buchowski H, Ksiazczak A, Pietrzyk S. Solvent activity along a saturation line and solubility of hydrogen-bonding solids J. Phys. Chem., 1980; 84: 975 − 979.
26.    Patel A, Vaghasiya A, Gajera R, Baluja S. Solubility of 5-Amino Salicylic Acid in Different Solvents at Various Temperatures J. Chem. Eng. Data, 2010; 55: 1453−1455.
27.    Dong X., Cao Y., Lin H., Yao Y., Guo Y., Wang T., Wu S., Wu Z., Solubilities of formononetin and daidzein in organic solvents: Effect of molecular structure and interaction on solvation process J. Mol. Liq. 231 (2017) 542–554.
28.    Mahali K., Guin P.S., Roy S., Dolui B.K., Solubility and solute–solvent interaction phenomenon of succinic acid in aqueous ethanol mixtures J. Mol. Liq. 229 (2017) 172–177.
29.    Kalam M.A., Khan A.A., Alshamsan A., Haque A., Shakeel F., Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions J. Mol. Liq. 249 (2018) 53–60.
30.    Ha E.S., Lee S.K., Jeong J.S., Shim W.Y., Yang J.I., Kim J.S., Kim M.S., Solvent effect and solubility modeling of rebamipide in twelve solvents at different temperatures J. Mol. Liq. 288 (2019), 111041.
31.    Zhou G., Wang B., Dong L.J., Wang F., Feng C., Measurement and correlation of the solubility of Lidocaine in eight pure and mixed solvents at temperatures from (292.15 to 332.15) K J. Mol. Liq. 242 (2017) 168–174.

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Samiksha Warke, Prashant Warke, M.K. Kale, Vipin Saini

DOI: Not Available         Access: Open Access Read More

Author(s): Hitendra Choudhary, Bhagwan Yadav, Pankaj Patel, Prabhat Das, Sujit Pillai

DOI: 10.5958/0974-360X.2019.00645.0         Access: Open Access Read More

Author(s): Anshu Sharma, CP Jain, MS Ashawat

DOI:         Access: Open Access Read More

Author(s): Asija Rajesh, Patel Pinkesh, Asija Sangeeta

DOI: Not Available         Access: Open Access Read More

Author(s): Anuradha A. Ranpise, Shilpa P. Chaudhari, Atul A. Phatak, Pratiksha M. Kadam

DOI: Not Available         Access: Open Access Read More

Author(s): Arnab Samanta*, Amitava Roy, Mrityunjoy Majumdar

DOI: 10.5958/0974-360X.2018.00124.5         Access: Open Access Read More

Author(s): Mohamed Rizwan I, Damodharan N

DOI: 10.5958/0974-360X.2020.00247.4         Access: Closed Access Read More

Author(s): A Pavan Kumar, J Satyanaryana, V Sai Kishore, TE Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles