Author(s): Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Rajesh Kumar, Anand Kumar Chaudhary, Amit Bhatia

Email(s): ,

DOI: 10.5958/0974-360X.2021.00261.4   

Address: Dileep Singh Baghel1*, Amit Mittal1*, Saurabh Singh1, Rajesh Kumar1, Anand Kumar Chaudhary2, Amit Bhatia3
1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar - Delhi G.T. Road, Phagwara, Punjab (India)-144411.
2Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
3Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Punjab, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021

Background: Punarnava (B. diffusa Linn.) is usually prescribed in India as traditional medicine in the management of renal miseries including CaOx (calcium oxalate) urolithiasis (Mutrakrichra). It occurs commonly as a weed throughout India. Out of the forty species of this genus B. diffusa, B. chinensis, B. erecta, B. rependa, and B. rubicunda have Indian originates. Objective: To prepare Punarnava ghan tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Punarnava kwath churna were prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kwath. Prepared ghan was compressed into tablet, and for evaluating the quality of tablets standard parameters were determined. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 50 % of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Punarnava ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to so remarkable in vitro activity against Urolithiasis (Mutrakrichra).

Cite this article:
Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Rajesh Kumar, Anand Kumar Chaudhary, Amit Bhatia. Formulation and Evaluation of In vitro Potential of Punarnava ghan Tablet against Urolithiasis (Mutrakrichra). Research J. Pharm. and Tech 2021; 14(3):1469-1476. doi: 10.5958/0974-360X.2021.00261.4

Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Rajesh Kumar, Anand Kumar Chaudhary, Amit Bhatia. Formulation and Evaluation of In vitro Potential of Punarnava ghan Tablet against Urolithiasis (Mutrakrichra). Research J. Pharm. and Tech 2021; 14(3):1469-1476. doi: 10.5958/0974-360X.2021.00261.4   Available on:

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