Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Rajesh Kumar, Anand Kumar Chaudhary, Amit Bhatia
email@example.com , firstname.lastname@example.org
Dileep Singh Baghel1*, Amit Mittal1*, Saurabh Singh1, Rajesh Kumar1, Anand Kumar Chaudhary2, Amit Bhatia3
1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar - Delhi G.T. Road, Phagwara, Punjab (India)-144411.
2Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
3Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Punjab, India.
Volume - 14,
Issue - 3,
Year - 2021
Background: Punarnava (B. diffusa Linn.) is usually prescribed in India as traditional medicine in the management of renal miseries including CaOx (calcium oxalate) urolithiasis (Mutrakrichra). It occurs commonly as a weed throughout India. Out of the forty species of this genus B. diffusa, B. chinensis, B. erecta, B. rependa, and B. rubicunda have Indian originates. Objective: To prepare Punarnava ghan tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Punarnava kwath churna were prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kwath. Prepared ghan was compressed into tablet, and for evaluating the quality of tablets standard parameters were determined. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 50 % of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Punarnava ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to so remarkable in vitro activity against Urolithiasis (Mutrakrichra).
Cite this article:
Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Rajesh Kumar, Anand Kumar Chaudhary, Amit Bhatia. Formulation and Evaluation of In vitro Potential of Punarnava ghan Tablet against Urolithiasis (Mutrakrichra). Research J. Pharm. and Tech 2021; 14(3):1469-1476. doi: 10.5958/0974-360X.2021.00261.4
1. Khan, Saeed R., Margaret S. Pearle, William G. Robertson, Giovanni Gambaro, Benjamin K. Canales, Steeve Doizi, Olivier Traxer, and Hans-Göran Tiselius. Kidney stones. Nature Reviews Disease Primers 2 (2016): 16008
2. Selvam, R., P. Kalaiselvi, A. Govindaraj, V. Bala Murugan, and AS Sathish Kumar. Effect of A. lanata leaf extract and Vediuppu chunnam on the urinary risk factors of calcium oxalate urolithiasis during experimental hyperoxaluria. Pharmacological Research 43, no. 1 (2001): 89-93
3. Moe, Orson W. Uric acid nephrolithiasis: proton titration of an essential molecule? Current opinion in nephrology and hypertension 15, no. 4 (2006): 366-373
4. Bhasin, Bhavna, Hatice Melda Ürekli, and Mohamed G. Atta. Primary and secondary hyperoxaluria: understanding the enigma. World journal of nephrology 4, no. 2 (2015): 235
5. Hoppe, Bernd, Ernst Leumann, Gerd von Unruh, Norbert Laube, and Albrecht Hesse. Diagnostic and therapeutic approaches in patients with secondary hyperoxaluria. Front Biosci 8, no. 1-3 (2003): e437-e443
6. Moe, Orson W. Kidney stones: pathophysiology and medical management. The lancet 367, no. 9507 (2006): 333-344
7. Awasthi, Madhvi, S. R. Malhotra, and Rajni Modgil. Dietary Habits of Kidney Stone Patients of Kangra District, Himachal Pradesh, North India. Journal of Human Ecology 34, no. 3 (2011): 163-169
8. Evan, Andrew P. Physiopathology and etiology of stone formation in the kidney and the urinary tract. Pediatric Nephrology 25, no. 5 (2010): 831-841
9. Singh, Kshetrimayum Birla, and Saitluangpuii Sailo. Understanding epidemiology and etiologic factors of urolithiasis: an overview. Sci Vis 13, no. 4 (2013): 169-174
10. Gault, M. H., and L. Chafe. Relationship of frequency, age, sex, stone weight and composition in 15,624 stones: comparison of results for 1980 to 1983 and 1995 to 1998. The Journal of urology 164, no. 2 (2000): 302-307
11. Coe FL, Evan A, Worcester E. Kidney stone disease. J Clin Invest 2005; 115:2598–2608
12. Khan F, Haider MF, Singh MK, et al. A comprehensive review on kidney stones, its diagnosis and treatment with allopathic and ayurvedic medicines. Urol Nephrol Open Access J. 2019;7(4):69‒74
13. Romero, Victoriano, Haluk Akpinar, and Dean G. Assimos. Kidney stones: a global picture of prevalence, incidence, and associated risk factors. Reviews in urology 12, no. 2-3 (2010): e86.
14. Heywood, Vernon Hilton, D. M. Moore, Judith Dunkley, and Christabel King, eds. Flowering plants of the world. Vol. 336. Oxford: Oxford University Press, 1978.
15. Samhita, Charak, and Kashinath Sastri. Chaukhambha Bharti Academy. Varansi, Reprint 79 (2013): 80-84
16. Sushruta. Sutrasthana, chapter 38, verse 4, 13, 67 and chapter 42, verse 11. In: Sushruta Samhita. Shashtri AD. editor. Varanasi: Chaukhambha Sanskrita Sansthan, 2001
17. Vagbhata, Astanga Sangraha. Sutrasthana 178/103. Saroj Hindi commentary by Indradev Tripathi, Chaukhamba Sanskrit Pratisthan, Varanasi 5 (2005): 27.
18. Chunekar, Krsihna Chand, and G. S. Pandey. Bhavprakash nighantu. Hindi Commentary, Chukhamba Bharti Academy Varanasi, Reprint 314 (2004): 212.
19. Shodhala, Nighantu of Shodhala by Prof. P.V. Sharma publisher Chaukhambha Vidyabhawan,Varanasi,Reprint-1972
20. Kamat, S. D., and S. D. Kamat. Dhanvantari nighantu. Delhi: Chaukhambha Sanskrit Pratisthan (2002): 1.
21. Pandey, G. Madanpal Nighantu. Varanasi: Chowkhambha orientalia (2012)
22. Vaidya, Bapalal G. Nighantu adarsha. Chaukhambha Bharati Academy, Vanarasi, 2nd Ed. I (1998): 211-214
23. Sharma, Acharya Priyavrata. Commentary on Kaidev Nighantu (Gavya Ghrita Guna-271)-Chaukhambha Orientalia. (2009).
24. Narahari, Pandit, and Raj Nighantu. Indradev Tripathi. Krishna Das Academy, Varanasi, p.-29 416 (2003): 443.
25. Vaidyacarya Bopadeva, Hridayadipaka Nighantu with PRAKASA commentary of Vopadeva By Prof. P.V. Sharma, Publisher chaukhambha Amarabharati prakashan,Varanasi,Print-1977
26. Sharma, Priya Vrat. Priya Nighantu. Chaukamba Bharti Academy, Varanasi (1983).
27. Evans, William Charles. Trease and Evans Pharmacognosy E-Book. Elsevier Health Sciences, 2009.
28. Sharma, P. C., M. B. Yelne, and T. J. Dennis. Database on medicinal plants used in Ayurveda. Vol. 1-3. New Delhi: CCRAS, 2005
29. Kirtikar, K. R., and B. D. Basu. Indian Medicinal Plants: periodical book agency. New Delhi 1 (1998): 686-689.
30. Anonymous. The Ayurvedic Pharmacopoeia of India, Part I, Vol 1-Vol 9 and Part II, Vol 1-Vol 3, Government of India, Ministry of Health and Family Welfare. Department of AYUSH, Delhi
31. Lohar, D. R. Protocol for testing Ayurvedic, Siddha and Unani medicines, Government of India Department of AYUSH. Ghaziabad: Ministry of Health & Family Welfare, Pharmacopoeial Laboratory for Indian Medicines (2007): 21.
32. Gupta, A.K., Neraj Tandon., and Madhu Sharma. Quality Standard of Indian Medicinal Plants (Vol. I, II, III, IV, VII, VIII. Indian Council of Medicinal Research, 2003, 2005, 2006, 2008, 2010
33. Mannhold, Raimund, Helmut Buschmann, and Jorg Holenz. Innovative Dosage Forms: Design and Development at Early Stage. Vol. 76. John Wiley & Sons, 2019
34. Lachman, Leon, Herbert A. Lieberman, and Joseph L. Kanig. The theory and practice of industrial pharmacy. Lea & Febiger, 1986
35. Rowe, Raymond C., Paul Sheskey, and Marian Quinn. Handbook of pharmaceutical excipients. Libros Digitales-Pharmaceutical Press, 2009.
36. Haritha, B. A Review on Evaluation of Tablets. Journal of Formulation Science & Bioavailability 1, no. 1 (2017): 1-5
37. Ahmed, Salman, Muhammad Mohtasheemul Hasan, and Zafar Alam Mahmood. In vitro urolithiasis models: An evaluation of prophylactic management against kidney stones. Journal of Pharmacognosy and Phytochemistry 5, no. 3 (2016): 28
38. Shah, Muhammad Ajmal, Sikandar Khan Sherwani, Mohammad Sualeh, Sandaleen Kanwal, Haq Nawaz Khan, and Shahana Urooj Kazmi. In vitro anthelmintic and antiurolithic assessment of Berberis lycium root bark. Journal of Pharmacognosy and Phytochemistry 3, no. 2 (2014)