Author(s): Jagadeeshwar K, Umasankar Kulandaivelu, Rajasekhar Reddy Alavala, GSN Koteswara Rao, DSNBK Prasanth, Nagaraja Sreeharsha

Email(s): jagdishoncology@gmail.com

DOI: 10.5958/0974-360X.2021.00258.4   

Address: Jagadeeshwar K1*, Umasankar Kulandaivelu1, Rajasekhar Reddy Alavala1, GSN Koteswara Rao1, DSNBK Prasanth1, Nagaraja Sreeharsha2
1K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India - 522502.
2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
The present study was planned to assess the anti-obesity efficacy of petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extract of peel of Pithecellobium dulce in high fat diet (HFD) induced obese rats. Methodology: Petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extracts were prepared by soxhlet method. The Wistar rats were induced obesity by giving high fat diet for 40 days. Anti-obesity effect was assessed by various extract of Pithecellobium dulce at two different dose levels (100 and 200mg/kg; p.o.,) along with high fat diet for 40 days. Orlistat at a dose of 50mg/kg was used as standard drug. The anti-obesity activity was assessed in terms of body weight gain, food intake, organ fat pad, liver and kidney weights. Results: Administration of high fat diet for 40 successive days significantly increased the body weight, food intake, organ and fat pad weights, Animals treated with extracts for 40 successive days along with high fat diet reversed the effects induced by high fat in dose depen¬dent manner. Conclusion: The present study depicts that the Petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extract of peel of Pithecellobium dulce shows potential anti-obesity effect.


Cite this article:
Jagadeeshwar K, Umasankar Kulandaivelu, Rajasekhar Reddy Alavala, GSN Koteswara Rao, DSNBK Prasanth, Nagaraja Sreeharsha. Evaluation of Anti-obesity of Pithecellobium dulce against high fat diet Induced Obesity in Experimental Animals. Research J. Pharm. and Tech 2021; 14(3):1447-1452. doi: 10.5958/0974-360X.2021.00258.4


REFERENCES:
1.    Birari RB, Gupta S, Mohan CG and Bhutani KK. Anti-obesity and lipid lowering effects of Glycyrrhiza chalcones: Experimental and computational studies. Phytomedicine. 2011; 18: 795-801.
2.    World Health Organization, 1998. Obesity: Preventing and managing the global epidemic. Report of a WHO Consultation on obesity, WHO/NUT/NCD/98, Geneva, Switzerland. 1-275.
3.    M. Selvakumar, Vijayalakshmi Ch, Venkata Rathina Kumar Th. Anti-obesity activity of Ficus religiosa on high fat diet induced model. Research J. Pharm. And Tech. 2015; 8(6): 679-682. - 3
4.    Centre WM (2015) Obesity and overweigh. World Health Organization.
5.    Jong Won Yun. Possible anti-obesity therapeutics from nature – A review. Phytochemistry. 2010; 71 (14-15): 1625-1641.
6.    Satyajit Patra, S Nithya, B Srinithya and Meenakshi SM. Review of medicinal plants for anti-obesity activity. Translational Biomedicine. 2015; 6(3:21): 1-22.
7.    Duke JA, Wain KK. Medicinal plants of the world. Computer index with more than 85,000 entries. 1981; 3: Longman group UK Limited.
8.    M Sugumaran, T Vetrichelvan, S Darlin Quine. Anti-inflammatory activity of Folklore: Pithecellobium dulce Benth. Research J. Pharm. and Tech. 2009; 2(4): 868-869.
9.    Megala J and Geetha A. Free radical-scavenging and H+/K+ ATPase inhibition activities of Pithecellobium dulce. Food Chem. 2010; 121: 1120-1128.
10.    Sukantha TA, Shubashini K. Sripathi, Ravindran NT and Balashanmugam P. Evaluation of in-vitro anti-oxidant and anti-bacterial activity of Pithecellobium dulce benth fruit peel. Inter. J. of current Research. 2011; 3(1): 378-382.
11.    Prasenjit Manna, Sudip Bhattacharyya, Joydeep Das, Jyotirmoy Ghosh and Parames C Sil. Phytomecicinal role of Pithecellobium dulce against CCl4-medicated hepatic oxidative impairment and necrotic cell death. Evidence Based Complementary and Alternative Medicine. 2011; Article ID 832805: 1-17.
12.    Mule VS, Naikwade NS, Magdum CS and Jagtap VA. Effect of Pithecellobium dulce benth leaves in dexamethasone induced diabetic rats. Inter. J. of Pharm. Pharmc. Seci. 2016; 8(9): 317-320.
13.    Shetty Sudeep Dinesh, Karunakar Hegde. Anti-obesity activity of ethanolic extract of Citrus maxima leaves on cafeteria diet induced and drug induced obese rats. Research J. Pharm. And Tech. 2016; 9(7): 907-912.
14.    Shetty Sudeep Dinesh, Karunakar Hegde. Anti-obesity activity of ethanolic extract of Citrus maxima leaves on cafeteria diet induced and drug induced obese rats. Research J. Pharm. And Tech. 2016; 9(7): 907-912.
15.    R Kalavani, R Sabitha Banu, KA Jeyanthi, T Umasankar and A Vinoth Kanna. Evaluation of anti-inflammatory and anti-bacterial activity of Pithecellobium dulce (benth) extract. Biotechnol Res. 2016; 2(4): 148-154.
16.    Kasarla Raju and Jagadeeshwar K. Phytochemical investigation and hepatoprotective activity of ripe fruits of Pithecellobium dulce in albino rats. Sch. Acal. J. Pharm. 2014; 3(6): 449-454.
17.    SP Anand and S Deboran. Preliminary phytochemical screening of wild edible fruits from Boda and Kolli hills. Journal of Medicinal Herbs and Ethnomedicine. 2017; 3: 8-12.
18.    Sunil HG, Archana MR. TLC profiling of Pithecellobium dulce seed. Research J. Pharmacognosy and Phytochemistry. 2012; 4(4): 220-222.
19.    Jayaram Megala and Arumugam Geetha. Acute and Sub-acute toxicity study of hydroalcoholic fruit extract of Pithecellobium dulce. Natural Product Research. 2012; 26(12): 1167-1171.
20.    Vasselli JR, Weindruch R, Heymsfield SB, Pi-Sunyer FX, Boozer CN, Yi N, Wang C, pietrobelli A and Allison DB. Intentional weight loss reduces mortality rate in a rodent model of dietary obesity. Obes Res. 2005; 13(4): 693-702.
21.    Rashmi Saxena Pal, Nikita Saraswat, Yogendra Pal, Pranay Wal, Ankita Wal, AK Rai. Alcoholic extract of poly herbal powder mixture for anti-obesity effect on wistar rats. Research J. Pharm. And Tech. 2019; 12(4): 1857-1864.
22.    Sai Sruthi Kaveripakam, Adikay Sreedevi and Gandhi Mathi. Anti-obesity efficacy of roots of Stereospermum suaveolens in high fat-induced obese rats. Journal of Young Pharmacists. 2017; 9(2): 234-238.
23.    Manjula B, Rayappa Hunasagi and Shivalinge Gowda KP. Anti-obesity activity of ethanalic extract of Moringa oleifera seeds in experimental animal. Research J. Pharmacology and Pharmacodynamics. 2011; 3(6): 3018-328.
24.    Souravh Bais, Guru Sewak Singh and Ramica Sharma. Anti-obesity and Hyperlipidemic activity of Moringa oleifera leaves against high fat diet-induced obesity in rats. Advances in Biology. 2014; Article ID 162914: 1-9.
25.    A Sowmya, T Ananthi. Hypolipidemic activity of Mimosa pudica Linn on butter induced hyperlipidemia in rats. Asian J. Res. Pharm. Sci. 2011; 1(4): 123-126.
26.    Preeti Tiwari. Antihyperlipidemic potential of Balarishta prepared by traditional and modern methods in high fat diet induced hyperlipidemic rats. Asian J. Res. Pharm. Sci. 2014; 4(1): 07-11.
27.    Srinivas G, Geeta HP, Shashikumar JN and Champawat. A review of Pithecellobium dulce: A potential medicinal tree. International Journal of Chemical Studies. 2018; 6(2): 540-544.
28.    Yogesh Saxena, Vartika Saxena, Jyoti Dvivedi and RK Sharma. Evaluation of dynamic function tests in normal obese individuals. Indian J. Physiol. Pharmacol. 2008; 52(4): 375-382.
29.    Bray GA, Loveloy JC, Smith SR, DeLany JP, Lefevre M, Hwang D, Ryan DH and York DA. The influence of different fats and fatty acids on obesity, insulin resistance and inflammation. J. Nutr. 2002; 132(9): 2488-2491.
30.    Estadella D, Oyama LM, Damaso AR, Ribeiro EB and Oller do Nascimento CM. Effect of palatable hyperlipidic diet in lipid metabolism of sedentary and exercised rats. Nutrition. 2004; 20(2): 2018-224.
31.    Yilmaz A, Suleyman H, Umudum Z and Sahim YN. The effect of adrenalectomy on leptin levels and some metabolic parameters in rats with diet-induced obesity. Biol Pharm Bull. 2002; 25(5): 580-583.
32.    Buettner R, Scholmerich J and Bollheimer LC. High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity. 2007; 15: 798-808.
33.    AM Gajda. High fat diets for diet-induced obesity models. Open diet purified formula for rats. Obesity. 2009; 1-9.
34.    Neyrinck AM, Bindels LB, De Backer F, Pachikian BD, Cani PD and Delzenne NM. Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action. International Immunopharmacology. 2009; 9(6): 767-773.
35.    Bernardis LL and Patterson BD. Correlation between ‘Lee index’ and carcass fat content in weanling and adult female rats with hypothalamic lesions. J. Endocrinol. 1968; 40(4): 527-528.
36.    Arch JR. The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol. 2008; 378(2): 225-240.
37.    Shivaprasad HN, Gopalakrishna S, Mariyanna B, Thekkoot M, Reddy R and Tippeswamy BS. Effect of Coleus forskohlii extract on cafeteria diet- induced obesity in rats. Pharmacog. Res. 2014; 69: 41-45.
38.    L. Landsberg, JB Young, WB Leonard, RA Linsenmeier and FW Turek. Isobesity associated with lower body temperatures? Core temperature: a forgotten variable in energy balance. Metabolism: Clinical and Experimental. 2009; 58(6): 871-876.
39.    MJ Heikens, AM Gorbach, HS Eden et al., Core body temperature in obesity. American Journal of Clinical Nutrition. 2011; 93(5)963-967.
40.    Yu Wen Huang, Yue Liu, Slavik Dushenkov, Chi-Tang Ho and Mou Taun Huang. Anti-obesity effects of epigallocatechin-3-gallate, orange peel extract, black tea extract, caffeine and their combinations in a mouse model. Journal of Functional Foods. 2009; 1(3): 304-310.
41.    Mukesh Kumar, Kiran Nehara, Duhan JS. Phytochemical analysis & antimicrobial efficacy of leaf extract of Pithecellobium dulce. Asian Journal of Pharmaceutical & Clinical Research. 2013: 6(1):70-76.
42.    M Sugumaran, T Vetrichelvan, S Darlin Quine. Antidiabetic potential of aqueous and alcoholic leaf extracts of Pithecellobium dulce. Asian J. Research Chem. 2009; 2(1): 83-85.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Josephin Nerling Rashida G., T. Venkatarathnakumar, R. Gowri, Ajithadhas Aruna

DOI: Not Available         Access: Open Access Read More

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Harsha Vardhani Kondepati, Girish Pai Kulyadi, Vamshi Krishna Tippavajhala

DOI: 10.5958/0974-360X.2018.00069.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags