Jagadeeshwar K, Umasankar Kulandaivelu, Rajasekhar Reddy Alavala, GSN Koteswara Rao, DSNBK Prasanth, Nagaraja Sreeharsha
Jagadeeshwar K1*, Umasankar Kulandaivelu1, Rajasekhar Reddy Alavala1, GSN Koteswara Rao1, DSNBK Prasanth1, Nagaraja Sreeharsha2
1K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India - 522502.
2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Volume - 14,
Issue - 3,
Year - 2021
The present study was planned to assess the anti-obesity efficacy of petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extract of peel of Pithecellobium dulce in high fat diet (HFD) induced obese rats. Methodology: Petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extracts were prepared by soxhlet method. The Wistar rats were induced obesity by giving high fat diet for 40 days. Anti-obesity effect was assessed by various extract of Pithecellobium dulce at two different dose levels (100 and 200mg/kg; p.o.,) along with high fat diet for 40 days. Orlistat at a dose of 50mg/kg was used as standard drug. The anti-obesity activity was assessed in terms of body weight gain, food intake, organ fat pad, liver and kidney weights. Results: Administration of high fat diet for 40 successive days significantly increased the body weight, food intake, organ and fat pad weights, Animals treated with extracts for 40 successive days along with high fat diet reversed the effects induced by high fat in dose depen¬dent manner. Conclusion: The present study depicts that the Petroleum ether (PE), ethyl acetate (EA) and methanolic (MA) extract of peel of Pithecellobium dulce shows potential anti-obesity effect.
Cite this article:
Jagadeeshwar K, Umasankar Kulandaivelu, Rajasekhar Reddy Alavala, GSN Koteswara Rao, DSNBK Prasanth, Nagaraja Sreeharsha. Evaluation of Anti-obesity of Pithecellobium dulce against high fat diet Induced Obesity in Experimental Animals. Research J. Pharm. and Tech 2021; 14(3):1447-1452. doi: 10.5958/0974-360X.2021.00258.4
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