Diabetes mellitus is described as a metabolic disorder of multiple etiologies characterized by insulin resistance, relative insulin deficiency and hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. It is predicted that by 2030 diabetes mellitus may affect up to 79.4 million individuals in India. In the present study four polyherbal formulations were collected from various places of Chhattisgarh state, India. These formulations were selected on the recommendation of local healers. The formulations were designated as F1, F2, F3 and F4. These formulations were administered to the rats in two different doses i.e. 200 and 400mg/kg body weight; glibenclamide was used as standard drug. The antidiabetic effect of these polyherbal formulations was studied in streptozotocin induced diabetic rats. The blood glucose level of diabetic rat significantly increased compared to normal rats. Maximum reduction was seen in animals treated with F4 at its both the doses. All the formulations significantly lowered the levels of cholesterol, triglycerides and LDL and at the same time HDL level increased in rats treated with extract and standard drug compared to untreated rats. The body weight of rats belonging to diabetic control group decreased significantly on induction of diabetes. The rats treated with extract and glibenclamide were found to gain body weight when compared to diabetic control group. It is interesting that in polyherbal formulation treated rats there was significant decrease in blood glucose level and also lipid peroxidation; the observation shows increased levels of the antioxidant enzymes and decrease in lysosomal enzymes. The potent antidiabetic effect of the polyherbal formulation suggests the presence of such phytoconstitutents that can produce significant antihyperglycemic activity as well as other biochemical changes that can protect from complications of diabetes. The result of present study also suggests that the claims made by the local healers about the efficacy of formulation is correct, however extensive study is required to determine the mechanism by which the activity take place and at the same time the biological markers present in the formulations that are responsible for the activity.
Cite this article:
Amit Roy, Pushpa P. Gupta, Shiv Bharadwaj, Shashikant Chandrakar. Antidiabetic activity of Polyherbal formulations from Chhattisgarh State. Research J. Pharm. and Tech. 2021; 14(3):1375-1379. doi: 10.5958/0974-360X.2021.00245.6
Amit Roy, Pushpa P. Gupta, Shiv Bharadwaj, Shashikant Chandrakar. Antidiabetic activity of Polyherbal formulations from Chhattisgarh State. Research J. Pharm. and Tech. 2021; 14(3):1375-1379. doi: 10.5958/0974-360X.2021.00245.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-3-33
1. Mehta SR, Kashyap AS, Das S. Diabetes Mellitus in India: The Modern Scourge. Med J Armed Forces India. 2009 Jan; 65(1): 50–54.
2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025 -Prevalence, numerical estimates and projections. Diabetes Care. 1998;21:1414–1431.
3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–1053.
4. Roy A, Prasad P. Assessment of Antihyperglycemic Potential of Lyophilized and Oven-Dried Extract of Calocybe indica in Experimentally Streptozotocin-Nicotinamide Induced Diabetic Rats. International Journal of Medical Research and Health Sciences. 2016, 5, 4:82-88.
5. Abhishek Saxena, Anil Middha, Vikas Saxena, Pankaj Mishra. Evaluation of Antidiabetic Activity of Different Extracts of Clitoria ternatea Leaves in STZ-Induced Diabetic Rats. UKJPB. 2016; 4(3): 69-73.
6. Maurya AK, Tripathi S, Kahrana M, Ahmed Z, Sahu RK. Evaluation of antidiabetic effects of Ficus racemosa extracts in diabetic induced rats. Pharmacologyonline. 2011; 3: 907-914.
7. Samyal ML, Ahmed Z, Bhushan S, Bhagat A, Das A, Samyal M. Scientific Validation of Antidiabetic Activity of Ethanol Extract of Ficus glomerata Barks and Roots in Streptozotocin-Induced Diabetic Rats. UK Journal of Pharmaceutical and Biosciences. 2014; 2(1): 42-46.
8. Molehin OR, Oloyede OI, Adefegha SA. Streptozotocin-induced diabetes in rats: effects of White Butterfly (Clerodendrum volubile) leaves on blood glucose levels, lipid profile and antioxidant status. Toxicol Mech Methods. 2018 Oct;28(8):573-586.
9. Kadali S. L .D. V. R. M, Das M. C, Vijayaraghavan R, Kumar M. V. Evaluation of Antidiabetic Activity of Aqueous and Ethanolic Extracts of Leaves of Chloroxylon swietenia in Streptozotocin (STZ) Induced Diabetes in Albino Rats. Biomed Pharmacol J 2017;10(3). 1347-1353.
10. Samyal ML, Ahuja A, Ahmed Z. Evaluation of Antidiabetic Activity of Isolated Compound from Ougeinia oojeinensis Bark Extract in Diabetic Rats. UK Journal of Pharmaceutical and Biosciences. 2014; 2(5): 27-33.
11. Tesfaye A, Makonnen E, Gedamu S. Hypoglycemic and antihyperglycemic activity of aqueous extract of Justicia schimperiana leaves in normal and streptozotocin-induced diabetic mice. International Journal of Pharma Sciences and Research. 2016; 7(2): 107-113.
12. Sharma U, Sahu RK, Roy A, Golwala DK. In vivo antidiabetic and antioxidant potential of Stephania hernandifolia in streptozotocin-induced-diabetic rats. Journal of Young Pharmacists. 2010; 2(3): 255-260.
13. Ratra M, Gupta R. Evaluation of antidiabetic activity of ethanol extracts of leaves and barks of Alangium salvifolium in streptozotocin-induced diabetic rats. UK Journal of Pharmaceutical and Biosciences. 2014; 3(3): 15-21.