Author(s): Ashok A. Hajare, Hemalata S. Dol

Email(s): ashok.hajare@bharatividyapeeth.edu

DOI: 10.5958/0974-360X.2021.00241.9   

Address: Ashok A. Hajare*, Hemalata S. Dol
Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur - 416103, (M.S.) India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
The present investigation aimed to design and fabricate terbinafine HCl (TH) loaded ethosomes for enhancement of transdermal delivery in the management of fungal diseases. The TH loaded ethosomes were explored initially by the selection of appropriate method amongst reported one and further optimized for best amongst the investigated. In present study, TH loaded ethosomes were prepared using cold method, ethanol injection method, and mechanical dispersion using rotary evaporator method and assessed for vesicle size, drug entrapment, zeta potential, and polydispersity index (PDI). The mechanical dispersion using thin film hydration method (vesicle size 126.6±1.55nm, entrapment efficiency 82.10±0.25%) was selected as an appropriate for development of TH ethosomes. Ethosomes prepared using thin film hydration method was optimized on the basis of concentration of TH: PL 90H (1:2, 1:4, 1:6 and, 1:8), hydroethanol 20-45%, volume of ethanol, stirring speed and sonication time. The comprehensive analysis revealed that concentration of PL 90H (TH: PL 90H ratio 1:2, 1:4, 1:6), hydroethanol 20-40% w/v with 10 mL ethanol for film formation following stirring speed 60 rpm, 100 rpm for rehydration of film and 30 min ultra-bath sonication were desired parameters for development of TH ethosomes. The aforementioned optimization results observed in the limit for vesicle size 105.56±2.77nm to 178.71±2.07 nm, entrapment efficiency 63.04±0.67% to 89.52±0.87% with -31 mV to -24 mV zeta potential indicating stability of vesicles. The recorded results indicate that mentioned optimization aspects can be useful for development of drug loaded ethosome with factorial design approach.


Cite this article:
Ashok A. Hajare, Hemalata S. Dol. Screening of effective formulation techniques for Designing and Fabrication of Terbinafine hydrochloride ethosomes. Research J. Pharm. and Tech. 2021; 14(3):1353-1359. doi: 10.5958/0974-360X.2021.00241.9

Cite(Electronic):
Ashok A. Hajare, Hemalata S. Dol. Screening of effective formulation techniques for Designing and Fabrication of Terbinafine hydrochloride ethosomes. Research J. Pharm. and Tech. 2021; 14(3):1353-1359. doi: 10.5958/0974-360X.2021.00241.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-3-29


REFERENCES:
1.    Zhang J et al. Ethosomes, binary ethosomes and transfersomes of terbinafine hydrochloride: A comparative study. Arch. Pharm. Res. 2012; 35(1): 109-11.
2.    Murade P et al. Formulation, development and evaluation of ethosomal drug delivery for terbinafine hydrochloride. Int. J. App. Pharm. 2014; 4(1): 74-82.
3.    Chourasia M et al. Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Res. Pharm. Sci. 2011; 13(1): 60-67.
4.    Monisha C et al. A review on ethosomes for transdermal application. Res. J. Pharm. And Tech. 2019; 12(7): 3133-3143.
5.    Cevc G et al. Functional characterization of novel analgesic product based on self-regulating drug carriers. Int. J. Pharm. 2008; 360(1): 18-28.
6.    Limsuwan T, Amnuaikit T. Development of ethosomes containing mycophenolic acid. Procedia Chem. 2012; 4(2): 328-335.
7.    Oghal S et al. Ethosomes: A novel drug delivery system and their therapeutic applications -A review. Research J. Pharm. and Tech. 2020; 13(4): 1970-1978.
8.    Narayana R et al. A comparative study of terbinafine ethosomal formulations: A novel approach. Nitte Univ. J. Health Sci. 2013; 3(4): 23-29.
9.    Jain S et al. Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route. Pharm. Dev. Technol. 2014; 20(4): 1–18.
10.    Tyagi L et al. Ethosomes: Novel vesicular carrier for enhanced transdermal drug delivery system. Bull. Pharm. Res. 2013, 3(1): 6-13.
11.    Sneh P et al. Formulation and optimization of ethosomes loaded with ropinirole hydrochloride: Application of quality by design approach. Res. J. Pharm. Tech. 2020; 13(9): 4339-4345.
12.    Zhai et al. Ethosomes for skin delivery of ropivacaine: Preparation, characterization and ex vivo penetration properties. J. Liposome Res. 2015; 25 (4): 316-324.
13.    Romero E, Morilla M. Highly deformable and highly fluid vesicles as potential drug delivery systems:   theoretical and practical considerations. Int. J. Nanomedicine. 2013; 8(1): 3171–86.
14.    Vanic Z. Phospholipid vesicles for enhanced drug delivery in dermatology. J. Drug Disco. Develop. Deliv. 2015; 2(1): 1010.
15.    Parashar et al. Ethosomes: A recent vesicle of transdermal drug delivery system. Int. J. Res. Dev. Pharm. L. Sci. 2013; 2(1): 285-292.
16.    Shish et al. Formulation and optimization of ethosomes for transdermal delivery of felodipine. Res. J. Pharm. Tech. 2012; 5(12): 1509-1517.
17.    David et al. Formulation and in vitro evaluation of ethosomes as vesicular carrier for enhanced topical delivery of isotretinoin. Int. J. Drug Deliv. 2013; 5(1): 28-34.
18.    Gupta et al. Transfersomes: A novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Sci. Pharm. 2012; 80(4): 1061–80.
19.    Dubey et al. Melatonin loaded ethanolic liposomes: Physicochemical characterization and enhanced transdermal delivery. Eur. J. Pharm. Biopharm. 2007; 67(2): 398-405.
20.    Gaikwad A., Transdermal drug delivery system: Formulation aspects and evaluation. Compr. J. Pharm. Sci. 2013;1(1): 1 – 10.
21.    Ghanbarzadeh S, Arami S. Enhanced transdermal delivery of diclofenac sodium via conventional liposomes, ethosomes, and transfersomes. BioMed. Res. Int. 2013; 1(1): 1-7.
22.    Has C, Sunthar P. A comprehensive review on recent preparation techniques of liposomes. J. Liposome Res. 2020; 30 (4): 1-8.
23.    Prasanthi D, Lakshmi P. Development of ethosomes with taguchi robust design-based studies for transdermal delivery of alfuzosin hydrochloride. Int. Curr. Pharm. J. 2012; 11(1): 370-375.
24.    Drazenovic et al. Effect of lamellarity and size on calorimetric phase transitions in single component phosphatidylcholine vesicles. Biochim. Biophys. Acta. 2015; 1848(2): 532-543.

Recomonded Articles:

Author(s): Basil K Varghese, Geraldine Bessie Amali D, Uma Devi K S

DOI: 10.5958/0974-360X.2019.00114.8         Access: Open Access Read More

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Moghal. Roohi Shabreen, S. Sangeetha

DOI: 10.5958/0974-360X.2020.00355.8         Access: Open Access Read More

Author(s): Atul Arvind Bodkhe, Ramandeep Singh Bedi, Ashutosh Upadhayay, Mohan K. Kale

DOI: 10.5958/0974-360X.2018.00998.8         Access: Open Access Read More

Author(s): Sayani Bhattacharyya, Hemant Adhikari, Durgaprasad Regmi

DOI: 10.5958/0974-360X.2019.00699.1         Access: Open Access Read More

Author(s): Monisha C, GNK. Ganesh, Mythili L, Kayalvizhi Radhakrishnan

DOI: 10.5958/0974-360X.2019.00529.8         Access: Open Access Read More

Author(s): A.Manimaran, V.M. Chandrasekaran, B. Praba

DOI: 10.5958/0974-360X.2016.00032.9         Access: Open Access Read More

Author(s): N. Madoria, M. Pathodiya, A. Tiwari

DOI: Not Available         Access: Open Access Read More

Author(s): Selvamuthukumar R., Murali R., Srinivasan N., Mohankumar A., Nitin Panicker

DOI: 10.5958/0974-360X.2020.00818.5         Access: Open Access Read More

Author(s): Qais Gasibat, Malak Hasan Mesrati , Rabiu Muazu Musa, Ahlam A. Zidan

DOI: 10.5958/0974-360X.2019.00742.X         Access: Open Access Read More

Author(s): Subhashis Debnath1*, Gampa Vijay Kumar2, Satayanarayana S.V.3

DOI: Not Available         Access: Open Access Read More

Author(s): Satish Balkrishna Bhise, Sevukarajan Mookkan

DOI:         Access: Open Access Read More

Author(s): Dyah Aryani Perwitasari, Imaniar Noor Faridah, Woro Supadmi, Mentari Yulistika, Sitti Nurdjaja Soltief, Elfride Irawati Sianturi, Nurul Masyitoh, Ajeng Diantini

DOI: 10.5958/0974-360X.2019.00041.6         Access: Open Access Read More

Author(s): Sunder Raj Manvi, V. R. M. Gupta, K. Srikanth, N. Devanna

DOI: Not Available         Access: Open Access Read More

Author(s): Stanekzai A, Sudhakar CK., Zhakfar AM., Vikrant. Singh Karan

DOI: 10.5958/0974-360X.2019.00783.2         Access: Open Access Read More

Author(s): T. M. Jondhalekar, S. S. Aher, R. B. Saudagar

DOI: 10.5958/0974-360X.2017.00320.1         Access: Open Access Read More

Author(s): Jose Prakash. D, Radhika Duggirala. L, Ariya. R, Thabitha Kumari

DOI: 10.5958/0974-360X.2017.00044.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags