Author(s): Aruna V. Chandak, Deepjit Bhuyan, Amol P. Singam, Bhakti Patil

Email(s): pooplibhuyan5@gmail.com

DOI: 10.5958/0974-360X.2021.00240.7   

Address: Dr. Aruna V. Chandak, Dr. Deepjit Bhuyan*, Dr. Amol P. Singam, Dr. Bhakti Patil
Department of Anaesthesia, Jawaharlal Nehru Medical College, DMIMS (DU), Sawangi, Wardha– 442004 Maharashtra.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
Background: Hemodynamic changes during cesarean delivery after spinal anesthesia are common. The hypotension seen after spinal anesthesia in a cesarean delivery can be treated by many agents. In the management of hypotension during spinal anesthesia for cesarean section, the effects of Phenylephrine, Ephedrine and Mephentermine were compared in this study based on the following parameters- 1. The efficacy of the vasopressor in treating hypotension 2. Incidence of undesirable side effects. Materials and method: This study included a total of 120 patients (ASA Grade I and II) undergoing elective cesarean section (with a normal singleton pregnancy, full term/near term) under spinal anesthesia. The patients were randomly allocated into three groups of 40 each. Group ‘P’ was given prophylactic bolus dose of Phenylephrine 100 mcg IV, Group ‘E’ was given prophylactic bolus dose of Ephedrine 10 mg IV and Group ‘M’ received prophylactic bolus dose of Mephentermine 6 mg IV. Blood pressure and heart rate was recorded every 2 minutes for 20 minutes and thereafter every 5 minutes till the end of the surgery. Results: In managing hypotension between the three groups, no difference was found between them. The incidence of bradycardia was higher in the Phenylephrine group. Conclusion: All the three vasopressors are effective (in intravenous form) in maintenance of maternal arterial pressure. Although Phenylephrine has quicker peak effect, in comparison to Ephedrine and Mephentermine and it causes reduction in heart rate.


Cite this article:
Aruna V. Chandak, Deepjit Bhuyan, Amol P. Singam, Bhakti Patil. Comparison of bolus phenylephrine, Ephedrine and Mephentermine for maintenance of Arterial pressure during Spinal anaesthesia in Caesarean section. Research J. Pharm. and Tech 2021; 14(3):1349-1352. doi: 10.5958/0974-360X.2021.00240.7

Cite(Electronic):
Aruna V. Chandak, Deepjit Bhuyan, Amol P. Singam, Bhakti Patil. Comparison of bolus phenylephrine, Ephedrine and Mephentermine for maintenance of Arterial pressure during Spinal anaesthesia in Caesarean section. Research J. Pharm. and Tech 2021; 14(3):1349-1352. doi: 10.5958/0974-360X.2021.00240.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-3-28


REFERENCES:
1.    Riley ET, Cohen SF, Rubenstein AJ, Flanaga B-Prevention of hypotension after spinal anesthesia for cesarean section, Anesthesia Analgesia. 1995; 81:838-842
2.    Cyna AM, Andrew M, Emmett RS, Middleton P, Simmons SW. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev 2006; 4: CD002251.
3.    Prakash S, Pramanik V, Chellani H, Salhan S, Gogia AR. Maternal and neonatal effects of bolus administration of ephedrine and phenylephrine during spinal anaesthesia for caesarean delivery: A randomized study. Int J Obstet Anesth. 2010; 19:24-30.
4.    Lee A, Warwick D, Kee N, Gin T. Trails of ephedrine versus phenylephrine for the management of hypotension during spinal anaesthesia for caesarean section. Anaesth Analg. 2002; 94:920-6.
5.    Kinsella SM. Lateral tilt for pregnant women. Why 15 degrees? Anaesthesia 2003; 58: 835-6.
6.    Dr. Kamalakannan M and Dr. Anandha Lakshmi D. Comparative Effect of Ephedrine, Mephentermine And Phenylephrine During Spinal Anesthesia. Annals of International Medical and Dental Research. Vol (3), Issue (3).
7.    Balki M, Carvalho JC. Intraoperative nausea and vomiting during cesarean section under regional anesthesia. Int J Obstet Anesth. 2005; 14:230-41.
8.    Rout CC, Rocke DA, Gouws E. Leg elevation and wrapping in the prevention of hypotension following spinal anaesthesia for elective caesarean section. Anaesthesia. 1993; 48:304-8.
9.    Erler I, Gogarten W. Prevention and treatment of hypotension during caesarean delivery. Anasthesiol Intensivemed Notfallmed Schmerzther. 2007; 42:208-13.
10.    Dinesh sahu, Dilip Kothari, Amrita Mehotra – Comparasion of bolus Ephedrine, Mephentermine and Phenylepherine for maintenance of arterial pressure during spinal anaesthesia for cesarean section – A clinical study. Indian Journal of Anaesthesia. 2003; 47(2):125-128
11.    Magalhães E, Govêia CS, Ladeira LC, Nascimento BG. Ephedrine versus phenylephrine: Prevention of hypotension during spinal block for cesarean section and effects on the fetus. Rev Bras Anestesiol. 2009; 59:11-20.
12.    M. Saravana Genesh, P. Padmavathi. Assess the Effectiveness of Intra Operative Video Therapy on Anxiety among patients under spinal anesthesia at selected hospital, Erode. Asian J. Nur. Edu. and Research. 2014; 4(1): 26-29.
13.    G. K. Dyade. Validated Derivative Spectrophotometric method for simultaneous estimation of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride from tablet formulations. Asian J. Pharm. Ana. 2019; 9(1):01-04.
14.    G. Kumaraswamy, Gandla Lalitha, K. Swetha, R. Suthakaran, G. Ramesh Babu. A Validated RP-HPLC Method for Simultaneous Estimation of Pseudoephedrine and Terfinadine in its Bulk and Pharmaceutical Dosage forms. Asian J. Pharm. Tech. 2014; 4(4): 200-204.
15.    U. Samba Moorthy, J. Sunil, M. Sanjith Nath. HPLC Method Development and Validation for Simultaneous Estimation of Ibuprofen and Pseudoephedrine in Pharmaceutical Dosage Forms. Asian J. Research Chem. 2010; 3(4): 859-861.
16.    Lohar V.R., Mane Aruna, Chavan Jaykar, Palled M.S., Bhat A.R. Simultaneous Estimation of Paracetamol, Caffeine, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Loratadine in Tablet Dosage form by RP-HPLC. Asian J. Research Chem. 2011; 4(7): 1141-1147.
17.    M. Saravanagenesh, P. Padmavathi. Assess the Effectiveness of Intra Operative Video Therapy on Anxiety among Patients under Spinal Anesthesia at Selected Hospital, Erode. Int. J. Nur. Edu. and Research. 2014; 2(3): 192-195.

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