Author(s):
Aithamraju Satishchandra, M. Surya Teja, V. Sravani, M. Chinna Eshwariah
Email(s):
satishchandrano.1@gmail.com
DOI:
10.5958/0974-360X.2021.00232.8 
Address:
Aithamraju Satishchandra1, M. Surya Teja1, V. Sravani1, M. Chinna Eshwariah2
1Department of Pharmacology, Anurag Pharmacy College, Ananthagiri, Kodad.
2Deparment of Pharmacognosy, Anurag Pharmacy College, Ananthagiri, Kodad.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2021
ABSTRACT:
In case of developing countries like India incidence rate kidney stones were significantly increased due to the life style modifications from the last two decades so the present study aimed to evaluate invitro urolithiasis activity of Thinopyrum intermedium on experimentally prepared calcium oxalate crystals. calcium oxalate crystals were prepared by homogenous ppt method by using calcium chloride and sodium oxalate. the crude extract was prepared by the simple maceration with methanol 1:3 ratio and the solvent was evaporated by rotary evaporator and two doses of extract selected i.e 10mg and 20mg and compared against standard cytosine all were assayed against calcium oxalate crystals which were incubated in semipermeable membrane with sulphuric acid. the results were 68.02% (10mg), 72.41% (20mg) and 90% and we conclude that the Thinopyrum intermedium was showed significant effect of urolithiasis.
Cite this article:
Aithamraju Satishchandra, M. Surya Teja, V. Sravani, M. Chinna Eshwariah. In vitro Urolithiasis activity of Thinopyrum intermedium methanolic extract on calcium oxalate crystals prepared by Precipitation method. Research J. Pharm. and Tech 2021; 14(3):1310-1312. doi: 10.5958/0974-360X.2021.00232.8
REFERENCES:
1. Ram J, Moteriya P, Chanda S. An overview of some promising medicinal plants with in vitro anti-urolithiatic activity. J Pharm 2015; 5:23-8
2. Sharma D, Dey YN, Sikarwar I, Sijoria R, Wanjari MM, Jadhav AD. In vitro study of aqueous leaf extract of Chenopodium album for inhibition of calcium oxalate and brushite crystallization. Egyptian J Basic Appl Sci 2016; 3: 164-71. Sci Res 1935. p. 8.
3. Vijaya T, Sathish Kumar M, Ramarao NV, Narendra Babu A, Ramarao N. Urolithiasis and its causes–short review. J Phytopharmacol 2013; 2:1-6.
4. 4.Niharika M, Himabindu J, Ramanjaneyalu K. Evaluation of invitro antiurolithiatic activity of Tridax procumbens. Int J Sci Res2018; 7:93-8.
5. Kumar BN, Kumar GK, Srinivasa V, Syed Bilal. A review on urolithiasis: Int J Universal Pharm Life Sci 2012; 2: 269-80.
6. Bijauliya RK, Alok S, Jain, S. K., Singh, V. K. and Singh, D., 2017. Herbal and allopathic medicine for kidney, gallbladder, and urinary stones: a review. Int J Pharm.
7. Abeygunasekara AM. Urinary stone disease in Sri Lanka. Ceylon Medical Journal 2011; 29:41-
8. Atodariya U, Barad R, Upadhyay S, Upadhyay U. Antiurolithiatic activity of Dolichosbiflorus seeds. J Pharmacogn Phytochem 2013; 2:209-13.
9. Abeygunasekara AM. Urinary stone disease in Sri Lanka. Ceylon Medical Journal 2011; 29:41-
10. Akinyeye AJ, Solanke EO, Adebiyi IO. Phytochemical and antimicrobial evaluation of leaf and seed of Moringa oleifera extracts. Int J Res Med Health Sci 2014; 4: 2307-83.
11. Bijauliya RK, Alok S, Jain, S. K., Singh, V. K. and Singh, D., 2017.Herbal and allopathic medicine for kidney, gallbladder, and urinary stones: a review. Int J Pharm.
12. Johri N, Cooper B, Robertson W, Choong S, Rickards D, Unwin R. an update and practical guide to renal stone management. Nephron Clin Practice 2010;116:c159–7.