Author(s): Himani Bajaj, Vinod Singh, Ranjit Singh, Tirath Kumar

Email(s): himanibajaj@gmail.com

DOI: 10.5958/0974-360X.2021.00230.4   

Address: Himani Bajaj1*, Vinod Singh 2, Ranjit Singh 3, Tirath Kumar1
1Department of Pharmaceutical Sciences, Bhimtal Campus, Kumaun University, Nainital.
2Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar.
3AVIPS, Shobhit University, Gangoh, Saharanpur.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
The surfactant-based amphiphilogels were prepared using different surfactant combinations, such as Span 60, Tween 80 and Tween 20. Different concentrations of gelator (Span 60) within the fluid phase (Tween 20 and Tween 80) was investigated to optimize the correct combination which can result in amphiphilogels. Various test formulations were prepared and evaluated for various physicochemical properties, such as physical appearance, homogeneity, percentage gelation and formulation pH. Optimized formulations were further evaluated for spreadability, rheology, drug content and in-vitro drug permeation. The formulations were also evaluated for their stability studies. The pH of the test formulations was found within the acceptable range for transdermal application. The ex-vivo skin permeation studies showed that all the formulation have good skin permeation property due to the presence of surfactant as a main structural framework. The formulation 19% w/w (F2) in span 60- tween 20 and 29% w/w (A3) span 60 -tween 80 showed greater rate of skin permeation among all formulations. The developed amphiphilogels could be a potential drug delivery system for hydrolytic drugs and it provides a good platform for the management of arthritis.


Cite this article:
Himani Bajaj, Vinod Singh, Ranjit Singh, Tirath Kumar. Preparation and Characterization of Aceclofenac-Loaded Amphiphilogels for Transdermal Drug Delivery. Research J. Pharm. and Tech 2021; 14(3):1298-1304. doi: 10.5958/0974-360X.2021.00230.4

Cite(Electronic):
Himani Bajaj, Vinod Singh, Ranjit Singh, Tirath Kumar. Preparation and Characterization of Aceclofenac-Loaded Amphiphilogels for Transdermal Drug Delivery. Research J. Pharm. and Tech 2021; 14(3):1298-1304. doi: 10.5958/0974-360X.2021.00230.4   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-3-18


REFERENCES:
1.    Wiedersberg S, Guy RH. Transdermal drug delivery: 30 + years of war and still fighting. Journal of Controlled Release. 2014; 190(28): 150-156.
1.    Patel RP, Patel G, Patel H, Baria A. Formulation and Evaluation of Transdermal Patch of Aceclofenac. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(2): 108-115.
2.    Verma A, Singh S, Kaur R, Jain UK. Transdermal gels as drug delivery systems: A review. International Journal of Pharmaceutical Science Review and Research. 2013; 23(2): 374-382.
3.    Murdan S, Ford J, Florence AT. Novel surfactant-in-surfactant amphiphilogels. Journal of Pharmacy and Pharmacology. 1998: 50 (9): 151.
4.    Nadeen J, Heenan RK, Murdan S. Amphiphilogels for drug delivery: Formulation and characterization. Pharmaceutical Research. 2004:21 (10); 1852-1861.
5.    Sudaxshina M, Andrýsek T, Son D. Novel gels and their dispersions-oral drug delivery systems for cyclosporin.International Journal of Pharmacy. 2005; 300 (1-2): 113-124.
6.    Jibry N, Heenan RK, Murdan S. Amphiphilogels for drug delivery: formulation and characterization. Pharmaceutical Research. 2004: 21 (10);1852–61.
7.    Nuha R, Abdul SM, Hajera H, Seema F. Simultaneous Formulation, Evaluation and estimation of controlled release of NSAID Drug. Asian Journal Pharmaceutical Analysis. 2017; 7(3): 176-184.
8.    Jibry N, Sarwar T, Murdan S. Amphiphilogels as drug carriers: effects of drug incorporation on the gel and on the active drug. Journal of Pharmcy and Pharmacology. 2006: 58 (2); 187-194.
9.    Prasad V, Kumar N, Mishra PR. Amphiphilic gels as a potential carrier for transdermal drug delivery. Drug Delivery. 2007: 14 (2); 75-85.
10.    Dsouza WZ, Gude MR. Formulation, design, development and evaluation of emulgel for transdermal delivery of meloxicam in the treatment of rheumatoid arthritis. Indo American Journal of Pharmceutical Research. 2015:5 (3); 5-3.
11.    Mundhada DR, Chandewar AV. Evaluation Study of in-situ Gel Using Catanionic Surfactant Mixtures. Research Journal of Science and Technology. 2016; 8(4): 165-178.
12.    Anuradha A Sawant, S.K. Mohite. Formulation and Evaluation of Itraconazole Emulgel for Topical Drug Delivery. Asian Journal of Pharmacy and Technology. 2015: 5(2); 91-96.
13.    Gharge D, Salve P, Raut C, Seervi C, Pawar K, Dhabale P. Validated Spectroscopic Method for Estimation of Aceclofenac from Tablet Formulation. Asian Journal of Research in Chemistry.2010: 3(1); 87-89.
14.    Chen MX, Alexander KS, Baki G. Formulation and evaluation of antibacterial creams and gels containing metal ions for transdermal application. Journal of Pharmacy. 2016; 1-10.
15.    Choudhury A, Roy A, Saha S, Bahadur S. Preparation and Evaluation of Phytocontituent Based Mucoadhesive Antifungal Vaginal Gel. Research Journal of Pharmacognosy and Phytochemistry. 2016; 8(3): 116-120
16.    Sarode SM, Bendale AR, Mittal M, Chaudhri MA, Kale MK, Vidyasagar G, Shrivastava B. Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System. Asian Journal of Research Chemistry. 4(5): May, 2011; 791-794.
17.    Sharma A, Saini S, Rana AC. Transdermal drug delivery system : a review. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2013; 4(1): 286-292.
18.    Atul PA, Chaudhari PD. Development and Evaluation of Nanogel as a Carrier for Transdermal Delivery of Aceclofenac. Asian Journal of Pharmacy and Technology. 2012; 2(4):125-132.
19.    Gupta S, Ahirwar D, Sharma NK, Jhade D. Proniosomal Gel as a Carrier for Improved Transdermal Delivery of Griseofulvin: Preparation and In-Vitro Characterization. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(1): 33-37.
20.    Aiyalu R, Govindarajan A, Ramasamy A. Formulation and evaluation of transdermal herbal gel for the treatment of arthritis in animal model. Brazilian Journal of Pharmaceutical Sciences 2016; 52(3): 493-507.
21.    Mallina SM, Sundararajan R. Diclofenac sodium loaded liposomal gel for transdermal delivery: Formulation, characterisation and pharmacokinetic evaluation. Research Journal of Pharmacy and Technology. 2018; 11(9): 4051-4062
22.    Raghavan SR. Distinct character of surfactant gels: a smooth progression from ratlles to fibrillar networks. Langmuir. 2009; 25 (15): 8382–8385.
23.    Huang X, Brazel CS. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. Journal of Controlled Release 2001; 73: 121–136.
24.    Trickett K, Eastoe J. Surfactant-Based Gels. Advances in Colloid and Interface Sciences. 2008; 144 (1-2): 66-74.
25.    Heinz H and Ulbricht W. Surfactant Gels. Current Opinion in Colloid and Interface Sciences. 1996; 1 (6): 726–739.
26.    Lakshmi PK, Kumar MK, Sridharan A, and Bhaskaran S. Formulation and evaluation of ibuprofen transdermal gel: A novel approach for penetration enhancement. International Journal of Applied Pharmacy. 2011; 3 (3): 25-30.
27.    Bharadwaj S, Gupta GD, and Sharma VK. Transdermal gel: A novel approach for drug delivery. Journal of Chemical, Biological and Physical Sciences. 2012; 2 (2): 856–867.
28.    Garg A, Aggarwal D, Garg S, Singla AK. Spreading of Semisolid Formulations: An update. Pharmaceutical Technology. 2002; 84-105.
29.    Pal K, Kumar N, Bhattacharya C, Sagiri SS, Ray SS. Development of span 80-tween 80 based fluid-filled organogels as a matrix for drug delivery. Journal of Pharmaceutical Biological Sciences. 2012; 4 (2): 155-163.

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Kishore Manoharan, Navya Ajitkumar Bhaskaran, Lalit Kumar

DOI: 10.5958/0974-360X.2019.01070.9         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags