Sudhir Patil, Prakash Nargatti, Tabassum Shikalgar, Nilofar Naikwade
Sudhir Patil*1, Prakash Nargatti2, Tabassum Shikalgar1, Nilofar Naikwade1
1Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, 416416 Maharashtra, India.
2Department of Pharmacology, Annasaheb Dange College of Pharmacy, Ashta, Sangli, 416 301 Maharashtra, India.
Volume - 14,
Issue - 3,
Year - 2021
People in modern society suffer from different psychiatric disorders, particularly the depression. The exact cause of depression is unknown, but researchers suggest that depression is due to imbalancing of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain. Factors that may contribute to depression include heredity, stress, chronic illnesses, certain personality traits and hormonal changes. However, several syntetic drugs are available in market, but all are associated with some limitations and there is an urgent need for alternative medications for these disorders. To date the search for novel pharmacotherapy from medicinal plants for psychiatric illness was significantly progressed. Therefore in the present study we evaluates the antidepressant activity of ethanolic extract of Ficus carica leaves by using Forced swimming test (FST) and Tail suspension test (TST) models. The results showed that the extract shows decrease in immobility time and significantly increase inthe level of biogenic amine along with reduction in monoamino oxidase enzyme that metabolizes biogenic amines in both experimental models as compared to the animals in the control group and Imipramine treated standard group. Therefore, based on present findings the Ficus carica can be used as potential resource for natural psychotherapeutic agent against depression. However, further investigations are required to determine the molecular level of target mechanism of the extract for further use in humans.
Cite this article:
Sudhir Patil, Prakash Nargatti, Tabassum Shikalgar, Nilofar Naikwade. Evaluation of Antidepressant activity of Ficus carica leaves extract in experimental animals. Research J. Pharm. and Tech 2021; 14(3):1267-1273. doi: 10.5958/0974-360X.2021.00224.9
1. World Health Organization, “Depression,” 2018, Accessed on 5 May 2020, https://www.who.int/news-room/fact-sheets/detail/depression.
2. Indu Sharma, Mandeep Kaur, Bharat Parashar, Amrita Kainth, Depression: An Overview, Asian Journal of Research in Pharmaceutical Sciences, 2014; 4(1):28-31.
3. G. E. Hodes, V. Kana, C. Menard, M. Merad, and S. J. Russo, “Neuroimmune mechanisms of depression,” Nature Neuroscience, 2015; 18(10):1386–1393.
4. Zhang Z., Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders, Life Sci, 2002; 70: 3077-3096.
5. Esra Küpeli Akkol, Fatma Tugçe Guragac Dereli and Mert Ilhan, Assessment of Antidepressant E ect of the Aerial Parts of Micromeriamyrtifolia Boiss. And Hohenon Mice, Molecules, 2019; 24(10):1-23
6. Pavithra H Dave, V. Vishnupriya, R. Gayathri, Herbal Remedies for Anxiety and Depression- A Review, Research Journal of Pharmacy and Technology, 2016; 9(8):1253-1256.
7. Joseph T. Dipiro Robert, Gary Barbura, L. Minchael. Pharmacotherapy A pathological approach. Sixth ed. New York, McGRAW-HALL Medical Publication Division; 1999: 1023-1025, 1235-1238.
8. Habibur Rahman, M.C Eswaraiah, Simple spectroscopic Methods for estimating Brain neurotransmitter, Antioxidant Enzyme of laboratory animal like mice: A review: Pharmatuor, Art-1244.
9. Patil Vikas V., Bhangale S.C., Patil V. R. Evaluation of anti-pyretic potential of Ficus carica leaves, International Journal of Pharmaceutical Sciences Review and Research, 2010; 2(2): 48-50.
10. Niran A. Al-Ogaili, Safa Osama, Doha Jazme, Sara Saad, In Vitro Antibacterial investigation and Synergistic Effect of Ficus carica and Olea europaea Aqueous Extracts, Research Journal of Pharmacy and Technology, 2020;13(3):1198-1203
11. S.B. Chandrasekar, M. Bhanumathy, A.T. Pawar, T. Somasundram, Phyatopharmacological review of Ficus religinosa, Pharmacognosy Review, 2010;4(8): 195-199.
12. VD Tambe, TR Katariya, RS Jadhav, Jagadeesh Singh SD, Anthelmintic Activity of Bark of Ficus carica, Research Journal of Pharmacy and Technology, 2009; 2(1): 206-207.
13. Rifa’atul Mahmudah, Silviana Hasanuddin, Ahmad Saleh, Wa Ode Yuliastri, Muhammad isrul, Antidepressant Activity and Identification of Chemical Compounds Extract Mustard Leaves (Brassica juncea L.), 2019;12(7): 3223-3227.
14. Habibur Rahman, M. Chinna Eswaraiah, Anoosha T., Nagaveni K., Manjula K., Evaluation for CNS Activities of Hexane Extract of Citrullus lanatus Seeds, Research Journal of Pharmacy and Technology, 2013; 6(8): 878-884.
15. R. S. Adnaik, P. S. Gavarkar, S. K. Mohite, C, S Magdum, Anti-Depressant Activity of Ethanolic Extract of Citrullus vulgaris Seeds in Experimentally Induced Depressed Mice, Research Journal of Pharmacy and Technology, 2014; 7(6): 660-662.
16. Habibur Rahman, M.C Eswaraiah. Simple spectroscopic Methods for estimating Brain neurotransmitter, Antioxidant Enzyme of laboratory animal like mice: A review, Pharmatutor, Art-1244.
17. Venkata Naveen Kasagana, Swathi Sree Karumuri, Effect of Wedelia paludosa (Asteraceae) on Brain Neurotransmitters and Enzyme Monoamine Oxidase, Following Cold Immobilization Stress, Research Journal of Pharmacy and Technology, 2011; 4(12): 1910-1911.
18. Daniele Bonivento, Erika M. Milczek, G. Reid Mcdonald, Claudia Binda, Andrew Holt, Dale E. edmondson and Andrea mattevi, potentiation of ligand binding through cooperative effects in monoamine oxidase b. The Journal of Biological Chemistry, 2010; 285(47): 36849–36856.
19. Dinesh Dhingra and parveen kumar goyal, Inhibition of MAO-A and GABA: Probable mechanism for antidepressant like activity for Nardostachys jatamansi DC. In mice. Indian Journal of Experimental Biology, 2008; 46:212-218.
20. Gui-Feng Hao, Mao-Qin Tang, Yan-Jin Wei, Feng-yuan Che and Li-ju Qian, Determination of antidepressant activity of Cyperusrotundus L extract in rats, Tropical Journal of Pharmaceutical Research, 2017; 16(4): 867-871.
21. Toshiko Ishikawa, Motoki Okano, Akiko Minami, Hiroko Tsunekawa, Hiroshi Satoyoshi, Yuka Tsukamoto, Kazue Takahata, Shizuko Muraoka, Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity, Behavioral Brain Research, 2019; 359: 353-361.
22. Anantha Lakshmi J, Satyavthi D., Evaluation of Anti Depressant and MAO Inhibitory Activity of Rhodiola rhodantha rhizome methanolic extract, Research Journal of Pharmacy and Technology, 2015; 8(3): 310-315.
23. G. Venkatesha, C. Kalaiyarasia, M. Ramanathana, Antidepressant like Effect of Gabapentin Decreases the Immobility Time in Despair Animal Models in Mice: Roll of Serotonergic System in it, Research Journal of Pharmacy and Technology, 2011; 4(11): 1702-1706.