Author(s): Hima Jose, K. Krishnakumar, Dineshkumar B

Email(s): stjamespharmacyproject@gmail.com

DOI: 10.5958/0974-360X.2021.00320.6   

Address: Hima Jose, K. Krishnakumar, Dineshkumar B*
Department of Pharmaceutics, St. James’ College of Pharmaceutical Sciences, Chalakudy, Kerala.
St. James’ Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy, Kerala.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
Wounds are inevitable in life. The rapid healing process can reduce the costs of the therapy and hospitalization but ideal availability of the drugs for wound healing therapy is limited due to the complex nature in the skin tissue. The novel medicines for wound healing and skin regeneration, herbal based therapeutics agents can be alternative medications. Recently, biologically active scaffolds have been widely used for wound healing therapy. These scaffolds are extracellular matrices and can able to induce tissue regeneration. Here, we present a review on several scaffolds by combining biological polymers with the extracts obtained from various plants. It should be noted that chemical and synthetic agents which are known to be harmful to the environment and human health, scaffolds were prepared with completely environment friendly herbal extracts with biological polymers, which are frequently used in biomedical field. Plant based scaffolds augments wound healing and provide better tissue regeneration with minimal negative effect on skin. Scaffolds can be prepared by choosing proper polymer and extract types which are combined to get unique properties of scaffolds to lead an innovative and eco- friendly approach in wound treatment applications.


Cite this article:
Hima Jose, K. Krishnakumar, Dineshkumar B. Herbal Extracts based Scaffolds for Wound Healing Therapy. Research J. Pharm. and Tech 2021; 14(3):1805-1810. doi: 10.5958/0974-360X.2021.00320.6


REFERENCES:
1.    Groeber. F, Holetier M, Hamel M, Hinderer S, Schenkelayland K. Skin tissue engineering -in vivo and in vitro applications. Advanced Drug Delivery. 2011; 63(4-5): 352-366.
2.    Finnson KW, Arany PR, Philip A. Transforming Growth Factor Beta Signaling in Cutaneous Wound Healing: Lessons Learned from Animal Studies. Adv Wound Care (New Rochelle). 2013; 2(5): 225-237.
3.    Finnson KW, McLean S, Di Guglielmo GM, Philip A. Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring. Adv Wound Care (New Rochelle). 2013; 2(5): 195-214.
4.    Francisca SY Wong, Amy CY Lo. Collagen based scaffolds for cell therapies in the injured brain. Journal of Stem Cell Research and Therapy. 2015; 5(2): 267.
5.    Garg T, Singh O, Saahil A, Murthy RSR. Scaffold: A novel Carrier for cell and Drug Delivery. Critical Reviews in therapeutic Drug Carrier Systems. 2012; 29(1): 1-63.
6.    Eltom A, Zhong G, Muhammad A. Scaffold techniques and designs in tissue engineering functions and purposes: A Review. Advances in Material Science and Engineering. 2019; 3429527: 1-13.
7.    Yildirimer L, THanh TKN, Seifalian M. A skin regeneration scaffolds: a ultimodal bottom approach. Trends in Biotechnology. 2012; 30(12): 638-648.
8.    Brahatheeswaran DY, Yoshida M, Toru SKD. Polymeric scaffolds in tissue engineering application: a review. International journal of Polymer Science. 2011: 1-19.
9.    Ranjana C, Madhuri D, Aroop K, Basu.B, Competent processing techniques for scaffolds in tissue engineering. Journal of Biotechnology Advances. 2016; 7097: 1-41.
10.    Hajialyani M, Tewari D, Sobarzo-Sanchez E, Nabavi SM, Farzaei HM, Abdollahi M. Natural product based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems. International Journal of Nanomedicine. 2018; 13: 5023-5024.
11.    Joseph B, Raj SJ. Pharmacognostic and phytochemical properties of Aloe Vera Linn – an overview. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4: 106-110.
12.    Dhivya S, Padma VV, Santhini E. Wound dressings - a review. Biomedicine (Taipei). 2015; 5(4): 22.
13.    Robson MC, Steed DL, Franz MG. Wound healing: biological features and approaches to maximize healing trajectories. Curr Prob Surg. 2001; 38:77–89.
14.    Meinel L, Kaplan DL. Silk constructs for delivery of musculoskeletal therapeutics. Adv Drug Deliv Rev. 2012 Sep;64(12):1111-22.
15.    Qi Y, Wang H, Wei K, Yang Y, Zheng RY, Kim IS, Zhang KQ. A review of structure construction of silk fibroin biomaterials from single structures to multi-level structures. International Journal of Molecular Sciences, 2017; 18(3), 237.
16.    Suganya S, Venugopal J, Ramkrishna S, Lakshmi BS, Giri Dev VR. Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration. International Journal of Biological Macromolecules. 2014; 68: 135-143.
17.    Suganya. S, Venugopal J, Agnes Mary S, Ramkrishna S, Lakshmi BS, Giri Devi VR. Aloe vera incorporated biomimetic nanofibrous scaffold: a regenerative approach for skin tissue engineering. Iran Polymer Journal. 2014; 23: 237-248.
18.    Jouybar A, Seyedjafari E, Ardeshirylajimim A, Zandi-Karimi A, Feizi N, Khani M, Pousti I. Enhanced skin regeneration by herbal extract–coated poly-l-lactic acid nanofibrous scaffold. Artif Organs. 2017; 41(11): E296-E307
19.    Peumans WJ, Van Damme EJM. Plant lectins: Versatile proteins with important perspectives in biotechnology. Biotechnol. Genet. Eng. Rev. 1998; 15: 199-228.
20.    Oliveria C, NIcolau JA, Teixeira Domingues L. cytotoxic effects of native and recombinant frutalin, a plant galactose-binding lectin on Hela cervical cancer cells. J. Biomed. Biotechno. 2011; 1: 1-9.
21.    Chaires-Martinez L, Salazar-Montoya J, Ramos-Ramirez E. Physiochemical and functional characterisation of the galactomannan obtained from mesquite seeds. European Food Research and Technology. 2008; 227: 1669-1676.
22.    Domingos De Sousa F, Vasconselos. PD, Feranda A. Hydrogel and membrane scaffold formulations of frutalin (breadfruit lectin) within polysaccharide galactomannan matrix have potential for wound healing. International Journal of Biological Macromolecules. 2019; 121: 429-442.
23.    Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D. Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int Immunopharmacol. 2014; 20: 322-330.
24.    Karri VVSR, Kuppusamy G, Satish Kumar M, Malayandi. Multiple biological actions of curcumin in the management of diabetic foot ulcer complications: a systemic review. Tropical Medical Surgery. 2015; 3: 2-10.
25.    Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. European Journal of Cancer. 2005; 41: 1995-1968.
26.    Karri VVSR, Kuppusamy G, Talluri SV, Mannemala SS, Kollipara R. Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing. International Journal of Biological Macromolecules. 2016; 93: 1519-1529.
27.    Rezaei M, Oryan S, Reza Nourani MR, Mofid M, Mozafari M. Curcumin nanoparticle- incorporated collagen/chitosan scaffolds for enhanced wound healing. Bioinspired. Biomimetic and Nanobiomaterials. 2018; 7: 159-166.
28.    Azis HA, Taher M, Ahmed AS, Sulaiman WMAW, Susanti D, Chowdhury SR, Zakaria. In vitro and In vivo wound healing studies of methanolic fraction of Centella asiatica extract. South African Journal of Botany. 2017; 108: 163-174.
29.    Kishore Babu M, Vamsikrishan B, Murthy TEGK. Formulation and evaluation of Centella asiatica extract impregnated collagen dermal scaffolds for wound healing. International Journal of Pharm. Tech. Research. 2011; 3: 1382-1391.
30.    Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF, Tam PK. Topical delivery of silver nanoparticles promotes wound healing. Chemmed Chem. 2007; 2: 129-136.
31.    You C, Li Q, Wang X, Wu P, Ho JK, Jin R, Zhang L, Shao H, Han C. Silver nanoparticle loaded collagen /chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation. Nature Scientific Reports. 2017; 7(1): 10489.
32.    Amarowicz R, Estrella I, Hernandez T, Robredo S, Troszynska A, Kosinka A, Peeg RB. Free Radical scavenging capacity, antioxidant activity and phenolic composition of green lentil (Lens culinaris). Food Chem. 2009; 121: 705-711.
33.    Vidyavathi M, Mobee Farhana SK, Sreedevi A, Suresh Kumar RV. Design and evaluation of lentil seed extract loaded bioscaffolds for wound healing activity. Biomedical and Pharmacology Journal. 2018; 11(1): 503-511.
34.    Andujar I, Recio MC, Giner RM, Rios JL. Traditional Chinese medicine to injury: the pharmacological basis for the use of shikonin as an anticancer therapy. Current Medicinal Chemistry. 2013; 20: 2892-2898.
35.    Kang HW, Tabata Y, Ikada Y. Fabrication of porous gelatin scaffolds for tissue engineering. Biomaterials. 1999; 20: 1339-1344.
36.    Yao CH, Chen KY, Chen YS, Li SJ, Huang CH. Lithospermi radix extract-containing bilayer nanofiber scaffold for promoting wound healing in a rat model. Mater Sci Eng C Mater Biol Appl. 2019; 96: 850-858.
37.    Ye Q, Zund G, Benedikt P, Jockenhoevel S, Hoerstrup SP, Sakyama S, Hubbell JA, Turina M. Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering. Eur. J. Cardiothorac. 2000; 17: 587-591.
38.    Tachibana A, Furuta Y, Takeshima H, Tanabe T, Yamauchi K. Fabrication of wool keratin sponge scaffolds for long term cell cultivation. Journal of Biotechnology. 2002; 93: 165-170.
39.    Williamson DH, Mellanby J, Krebs HA. Enzymatic determination of D (-)-beta-hydoxybutyric acid and acetoacetic acid in blood. Biochem. J. 1962; 82: 90-96.
40.    Singaravelu S, Ramanathan G, Sivagnanam UT. Dual layered 3D nanofibrous matrix incorporated with dual drugs and their synergistic effect on accelerating wound healing through growth factor regulation. Materials Science and Engineering C. 2017; 76: 37-49.
41.    Dasgupta N, Ranjan S, Mohammed SMA, Jadon PS, Melvins SS, Harris AD, Chakraborty A, Ramalingama R. Extraction –based blood coagulation activity of marigold: a comparative study. Comp Clin Path. 2014; 23: 1715-1718.
42.    Bhatnagar M, Parwani L, Sharma V, Ganguli J, Bhatnagar A. Hemostatic antibacterial biopolymers from acacia Arabica (lam) Wild and Moringa oleifera (Lam)as potential wound dressing materials. Indian J Exp Biol. 2013; 51: 804-810.
43.    Pedram Rad Z, Mokhtari J, Abbasi M. Preparation and characterization of Calendula officinalis-loaded PCL/gum arabic nanocomposite scaffolds for wound healing applications. Iranian Polymer Journal. 2019; 28: 51-63.
44.    Ron Jimenez RA, Millan D, Suesca E, Sosnik A, Fontanilla MR. Controlled release of an extract of Calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds: design and in vitro performance. Drug Deliv Transl Res. 2015; 5(3): 209-218.
45.    Habbal O, Hasson SS, El-Hag AH, Al-Mahrooqi Z, Al-Hashmi N, Al-Bimani Z, Al-Balushi MS, Al-Jabri AA. Antibacterial activity of Lawsonia inermis Linn (Henna) against Pseudomonas aeruginosa. Asian Pac J Trop Biomed. 2011; 1(3): 173-176.
46.    Azafarniam L, Norozi M. Multifunctional polyester fabric using a multi-component treatment. Fibrespolymers. 2016; 17: 298-304.
47.    Vakilian S, Norouzi M, Soufi-Zomorrod M, Shabani I, Hosseinzadeh S, Soleimani M. L. inermis-loaded nanofibrous scaffolds for wound dressing applications. Tissue cell. 2018; 51: 32-38.
48.    Biswas A, Amarajeewa M, Senapati S, Sahu M, Maiti P. Sustained release of herbal drugs using biodegradable scaffold for faster wound healing and better patient compliance. Nanomedicine: Nanotechnology, Biology and Medicine. 2018; 14: 2131-2141.

Recomonded Articles:

Author(s): Ankit Patel, Pankaj Kushwah, Sujit Pillai, Ajay Raghuvanshi, Nitin Deshmukh

DOI: 10.5958/0974-360X.2017.00013.0         Access: Open Access Read More

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): Rupali Deshmukh, Roshni Agrawal, Sarita Chauragde, Swati Lilhare, M. U. Mishra

DOI: 10.5958/0974-360X.2018.00831.4         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandeep DS, Narayana Charyulu R, Prashant Nayak, Aliss Maharjan, Indira Ghalan

DOI: 10.5958/0974-360X.2016.00163.3         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Sajid Ali, Maryam Shabbir, Nabeel Shahid

DOI: 10.5958/0974-360X.2015.00019.0         Access: Open Access Read More

Author(s): J. Rubika

DOI: Not Available         Access: Open Access Read More

Author(s): D. Benito Johnson, Appalaraju Gorle

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): G. Nithya Karpagam, Mahesh, Shanmugavel

DOI: 10.5958/0974-360X.2016.00179.7         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Author(s): Ranjitha Dhevi V. Sundar, Sugashini Settu, Saranya Shankar, Gayathri Segaran, Mythili Sathiavelu

DOI: 10.5958/0974-360X.2018.00153.1         Access: Open Access Read More

Author(s): Bhagyashree Purohit, Naveen Gupta, Shailesh Jain

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags