Author(s): Zahraa Ahmed Okhti, Baydaa H. Abdullah, Mayssaa E. Abdalah

Email(s): , ,

DOI: 10.5958/0974-360X.2021.00222.5   

Address: Zahraa Ahmed Okhti, Baydaa H. Abdullah, Mayssaa E. Abdalah
Clinical Laboratory Science Department, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021

Background: Hyperlipidemia is a routine way that may lead to damage effects on renal architecture. Hence, this work aimed to assesses both hyperlipidemia and the healing impact of lignan on histological of the kidney. Methods: Rabbits were divided into four groups, as the following: first Group ? diet free cholesterol for one month, second Group - diet with 1600mg/kg cholesterol for one month, third Group - diet with 1600mg/kg cholesterol for one month then received orally 40mg/kg/day of partial pure of SDG for two weeks. Removed kidney quickly to histological analysis. Results: Marked atrophy of glomeruli with dilated Boman space and large vacuolated of fatty changes of renal tubules, fibrosis and hyaline cast in the lumen of renal tubules beside that, in another section were seen thrombus in dilated blood vessels when animal suffer from hyperlipidemia. on another side, disappeared of atrophy, fibrosis, and thrombus when treated with partial pure lignan. Conclusions: These findings show that partial pure lignan leads to improving renal structure in rabbits models of hyperlipidemia.

Cite this article:
Zahraa Ahmed Okhti, Baydaa H. Abdullah, Mayssaa E. Abdalah. Healing Effect of Partial Pure Lignan against Renal Impaired Induced by High Fat Diet. Research J. Pharm. and Tech 2021; 14(3):1251-1254. doi: 10.5958/0974-360X.2021.00222.5

Zahraa Ahmed Okhti, Baydaa H. Abdullah, Mayssaa E. Abdalah. Healing Effect of Partial Pure Lignan against Renal Impaired Induced by High Fat Diet. Research J. Pharm. and Tech 2021; 14(3):1251-1254. doi: 10.5958/0974-360X.2021.00222.5   Available on:

1.    Kramer H, Luke A .Obesity and kidney disease: a big dilemma. Curr Opin Nephrol Hypertens. 2007;16:237–241.
2.    Liu Y, Wang Z, Yin W, et al. “Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/high-sucrose/high-cholesterol diet”. Experimental Animals. 2007; 56(1):11–20.
3.    Papafragkaki DK, Tolis G . “ Obesity and renal disease: a possible role of leptin”. Hormones (Athens). 2005; 4(2):90–95.
4.    Watanabe S, Hojo M, Nagahara A . “Metabolic syndrome and gastrointestinal diseases”. Journal Gastroenterol.2007; 42: 267–274.
5.    Innis SM . “Dietary lipids in early development: relevance to obesity, immune and inflammatory disorders”. Current Opinion  Endocrinology Diabetes Obesity.2007;14: 359–364.
6.    Altunkaynak BZ .” Effects of high fat diet induced obesity on female rat livers (a histochemical study)”. European Journal of General Medicine. 2005; 2: 100– 109.
7.    Oldenburg B, Pijl H . “Abdominal obesity: metabolic complications and consequences for the liver”. Ned Tijdschr Geneeskd. 2001; 145(39): 1290–1294.
8.    Altunkaynak BZ, Ozbek E, Altunkaynak ME . “A stereological and histological analysis of spleen on obese female rats, fed with high fat diet”. Saudi Medicine Journal. 2007; 28:353–357.
9.    Sarsilmaz M, Kaplan S, Songur A, et al.. “Effects of postnatal formaldehyde exposure on pyramidal cell number, volume of cell layer in hippocampus and hemisphere in the rat: A stereological study”. Brain Research. 2007; 1145: 157–167.
10.    De Castro et al . “Age-dependent effect of high fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats”. Lipids in Health and Disease.2013; 12(136).
11.    Okhti ,Z. A., Al-Ezzi M. I, AbdulmahdiR.” The protective role of flaxseed lignan in male rabbits with high fat diet: a histopathological study”. International Journal of Pharmacy and Pharmaceutical Sciences.2016; 8(11):90-94.
12.    Prasad, K.” Reduction of serum cholesterol and   hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinoldiglucoside isolated from flaxseed”. Circulation. 1999; 99: 1355-1362.
13.    Carleton, H.M., R.A. Drury and E.A. Wallington, . Carleton’s   Histological Technique. 5th Edn., Oxford University Press, ISBN-10: 0192613103, pp: 520,1980.
14.    Yoshimura N,Arima S, Nakayama M .”Renal Impairment AndIntraglomerular Mononuclear Phagocytes In Cholesterol-Fed Rabbits”.Nephron. 1994;68:473–480.
15.    Vazquez-Perez S, Aragoncillo P, de Las Heras N, Navarro-Cid J, Cediel E, et al. “Atorvastatin prevents glomerulosclerosis and renal endothelial dysfunction in hypercholesterolaemic rabbits”. Nephrol Dial Transplant. 2001;16 Suppl 1: 40–44.
16.    Hall JE: The kidney, hypertension, and obesity. Hypertension.2003;41:625–633.
17.    Hall JE, Kuo JJ, da Silva AA, de Paula RB, Liu J, TallamL. “Obesity-associated hypertension and kidney disease”. Current Opinion Nephrology and Hypertension. 2003; 12:195–200.
18.    Henegar JR, Bigler SA, Henegar LK, Tyagi SC, Hall JE. “Functional and structural changes in the kidney in the early stages of obesity”. Journal of  American  Society of  Nephrology. 2001; 12(6):1211–1217.
19.    EknoyanG. A history of obesity, or how what was good became ugly and then bad. Advanced in Chronic  Kidney Disease. 2006; 13(4):421–427 .
20.    Coritsidis G, Rifici V, Gupta S, et al.”Preferential binding of oxidizedLDL to rat glomeruli in vivo and cultured mesangial cells in vitro”. Kidney International. 1991;39(5):858–866.
21.    Wen M, SegererS, Dantas M, et al. “Renal injury in apolipoproteine-deficient mice”. Lab Invest. 2002;82:999–1006.
22.    Lavaud S, Michel O, Sassy-Prigent C,et al. “Early influx ofglomerular macrophages precedes glomerulosclerosis in the obese Zucker rat model”. Journal of the American Society of  Nephrology. 1996;7(12):2604–2615.
23.    Ding G, Pesek-Diamond I,Diamond JR .” Cholesterol, macrophages,and gene expression of TGF-beta 1 and fibronectin during nephrosis”.. American  Journal of  Physiology. 1993;264:F577–F584.
24.    Joles JA, Kunter U, Janssen U, et al. “Early mechanisms of renalinjury in hypercholesterolemic or hypertriglyceridemic rats”. Journal of the American Society of  Nephrology.2000;11(4):669–683.
25.    Pesek-Diamond I, Ding G, Frye J, et al. “Macrophages mediate adverseeffects of cholesterol feeding in experimental nephrosis”. American  Journal  Physiology. 1992;263:F776–F783.
26.    Hall Av, Parbtani A, Clark Wf, et al .”Abrogation Of Mrl/LprLupus Nephritis By Dietary Flaxseed”. American Journal Kidney Disease. 1993; 22:326–332.
27.    Peterson J, Dwyer J, Adlercreutz H, Scalbert A, Jacques P, McCullough ML. “Dietary lignans: physiology and potential for cardiovascular disease risk reduction”. Nutrition Reviews. 2010; 68(10):571–603.10.1111/j.1753-4887.2010.00319.
28.    Thompson LU, Robb P, Serraino M, Cheung F. “Mammalian lignan production from various foods”. Nutrition and Cancer. 1991; 16:43–52.
29.    Hirano T,Wakasugi A, Oohara M, et al. “Suppression of mitogeninduced proliferation of human peripheral blood lymphocytes by plant lignans”. Planta Medica. 1991; 57(4):331–334.
30.    Kitts DD, Yuan YV, Wijewickreme AN, Thompson LU. “Antioxidant activity of the flaxseed secoisolariciresinoldiglycoside and its mammalian lignan metabolites enterodiol and enterolactone”. Molecular and  Cellular Biochemistry.1999;202:91–100.
31.    Prasad K. “Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinoldiglucoside from flaxseed”. Circulation. 1999; 99:1355–1362.
32.    Clark Wf, Muir AD, Westcott ND, ParbtaniA.” A novel treatment for  lupus nephritis: Lignan precursor derived from flax”. Lupus. 1999; 9:429–4362000.

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