Author(s): Jessy Shaji, Twinkle Haresh Vaswani

Email(s): idjessy.shaji@gmail.com

DOI: 10.5958/0974-360X.2021.00176.1   

Address: Dr (Mrs) Jessy Shaji1*, Twinkle Haresh Vaswani2
1Professor, Department of Pharmaceutics, Principal. K.M. Kundnani College of Pharmacy, 23 Jote Joy Building, Ram Bhau Salgaonkar Road, Cuffe Parade, Mumbai, Maharashtra, India.
2Student in Master of Pharmacy, Research Scholar, Department of Pharmaceutics,
Principal. K.M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021


ABSTRACT:
Study here observes comparative effect of nanosponge loaded hydrogel of Benzydamine hydrochloride against combined effect of oro-dispersible tablet consisting of vitamin B complex; B2, B6 and B12, and Benzydamine hydrochloride loaded nanogel that was evaluated against standard to show efficacy. For this study thirty Albino Wistar male rats were selected. They were observed for healing score of the ulcers, and were analysed histologically. Rats were sacrificed on three, six, twelfth day of analysis. The histological score and the clinical examination showed that the efficacy of nanosponge hydrogel of Benzydamine hydrochloride and or odispersible tablet was effective as against the standard gel of Benzydamine hydrochloride as they release the drug in a controlled manner (due to incorporation in nanosponges) as compared to standard Benzydamine hydrochloride group. The groups treated with standard formulation, nanogel and orodispersible tablet with nanogel resulted a decrease in ulcer area after the third day and there was almost a complete healing after the twelfth day. The healing score for Benzydamine hydrochloride nanogel in combination with orodispersible tablet showed a better average healing score than the nanogel and standard. As compared to the control and blank group, standard gel, nanogel and combinative treatment showed lesser healing score. Benzydamine hydrochloride nanogel and combination treatment showed an increased state of mucosal repair, thus they can be used for treating mucosal ulcers effectively.


Cite this article:
Jessy Shaji, Twinkle Haresh Vaswani. Effect of Benzydamine Hydrochloride loaded Nanosponge formulations against mouth ulcers in Albino Wistar Rats. Research J. Pharm. and Tech. 2021; 14(2):986-990. doi: 10.5958/0974-360X.2021.00176.1


REFERENCES:
1.    Crispian Scully, Stephen Porter. Oral mucosal disease: Recurrent aphthous stomatitis. British Journal of Oral and Maxillofacial Surgery. 2008; 46(1): 198–206
2.    DMD Jonathan A. Ship. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology.1996;141-147
3.    Chun-Pin Chianget al. Recurrent aphthous stomatitis-Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. Journal of the Formosan Medical Association.2019; 118(9): 1279-1289
4.    L. Ge and M. Lin et al. Impact of hematologic deficiencies on recurrent aphthous ulceration: a meta-analysis. British Dental Journal 218.2015; E (5)
5.    Namrata M, Abilasha R. Recurrent aphthous stomatitis. International Journal of Orofacial Biology. 2017;1: 43-47
6.    Dr. Abhishek Dubey et al. Recurrent Aphthous stomatitis management- current trends and alternative modalities. International Journal of Current Research. 2016;8(8):37264-37271
7.    Lalla, Rajesh Vet al. Multivitamin Therapy for Recurrent Aphthous Stomatitis. Journal of American Dental Association. 2012; 143(4): 370–376
8.    Giulio Gasparini. The Use of Ropivacaine in Therapeutic Treatment of Oral Aphthosis. BioMed Research International. 2018
9.    Haisraeli-Shalish M et al. Recurrent aphthous stomatitis and thiamine deficiency. Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodontology. 1996;82(6):634–636
10.    Hsin-Li Liu RN MSN, Shu-Chin Chiu RN. The Effectiveness of Vitamin B12 for Relieving Pain in Aphthous Ulcers: A Randomized, Double-blind, Placebo-controlled Trial. Pain Management Nursing.2015,16(3):182-187
11.    Quane PA, Graham GG, Ziegler JB. Pharmacology of benzydamine. Inflammopharmacology. 1998;6(2):95-107
12.    Sharma Deepak, Sharma Amit, Garg Rajeev. Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis. Recent Patents on Drug Delivery and Formulation.2018;12(4): 277-294
13.    S.H. Abd El-Alim, A.A. Kassem, M. Basha. Proniosomes as a novel drug carrier system for buccal delivery of benzocaine. Journal of Drug Delivery Science and Technology. 2014; 24(5):452-458
14.    Noam Yarom DMD. The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology2017;123(6): 675-679
15.    Staines K, Greenwood M. Aphthous ulcers (recurrent). BMJ Clinical Evidence. 2015;1303.
16.    https://pubchem.ncbi.nlm.nih.gov/compound/Benzydamine-hydrochloride
17.    S. Y. Karavana (Hizarciog˘lu) et al. Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study. International. Journal of Oral Maxillofacial Surgery 2011; 40: 973–978
18.    Goswami Det al Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study. Journal of Dental Anesthesia and Pain Medicine. 2018 ;18(1):19-25
19.    B.L.A.M. Weusten and A. van de Wiel Netherlands. Aphthous ulcers and vitamin B12 deficiency. Journal of Medicine.1998;53:172–175
20.    Sveinsson SJ, Holy book WP. Oral mucosal adhesive ointment containing liposomal corticosteroid. International Journal Pharm 1993; 95:105–109
21.    OZkan Y et al In vitro release studies of chlorphenir- amine male ate from gels prepared by different cellulose derivatives. IlFarmaco. 2003; 58:605–611.
22.    https://www.lubrizol.com/Life-Sciences/Products/Carbopol-Polymer-Products/Carbopol-971P-NF-Polymer
23.    Karvana SY, Guneri P, Ertan G. Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: preparation, rheological, textural, mucoadhesive and release properties. Pharmaceutical Development and Technology.2009; 14:623–631.
24.    Fujısawa K., Mıyamoto Y., Nagayama M. Basic fibroblast growth factor and epidermal growth factor reverse impaired ulcer healing of the rabbit oral mucosa. Journal of Oral Pathology and Medicine. 2003; 32: 358–366.


Recomonded Articles:

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Author(s): Siddharth Kumar Sahu, Ajazuddin, Tripti Banjare, Swapnil Gupta, Akansha Bhandarkar, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Palak Agrawal, Pooja Yadav, Aditi Bhatt, Kailash Sahu, Deeksha Dewangan, HemlataThapa, Deepika, GyaneshSahu, Mukesh Sharma, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0974-360X.2018.00209.3         Access: Open Access Read More

Author(s): NKD Devi, AP Rani, BR Madhavi, BS Mrudula, A Swetha

DOI: Not Available         Access: Open Access Read More

Author(s): Srinivasa DS, Narayana Charyulu R, Satyanarayana DS, Srilakshmi D

DOI: 10.5958/0974-360X.2015.00249.8         Access: Open Access Read More

Author(s): Vishali T, Damodharan N

DOI: 10.5958/0974-360X.2020.00449.7         Access: Closed Access Read More

Author(s): Nitin Chandrakant Mohire, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad

DOI:         Access: Open Access Read More

Author(s): Anjan K. Mahapatra, Ranjit P. Swain, B. Revathi, N. Nirisha, P.N. Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Shanal Smitha Alva, Himanshu Joshi, Gururaja M. P, Prasanna Shama K , Ullas P D’souza

DOI: 10.5958/0974-360X.2018.00955.1         Access: Open Access Read More

Author(s): Pavithra Pradeep Prabhu, Chetan Hasmukh Mehta, Usha Y Nayak

DOI: 10.5958/0974-360X.2020.00626.5         Access: Closed Access Read More

Author(s): Jaybhaye Aarti, Joshi Sonali, Deshmukh Ganesh

DOI: Not Available         Access: Open Access Read More

Author(s): Sarvesh. C.N, Jennifer Fernandes, Suresh Janadri, Yogesh H.S, Shivakumar Swamy

DOI: 10.5958/0974-360X.2017.00043.9         Access: Open Access Read More

Author(s): Bhagat B.V., Darkunde S.

DOI: Not Available         Access: Open Access Read More

Author(s): Asha. D, Jeganath. S, U.V.N.V. Arjun, Sathesh Kumar. S

DOI: 10.5958/0974-360X.2018.00273.1         Access: Open Access Read More

Author(s): Srinivasa Sastry D, Narayana Charyulu R, Satyanarayana D S, Srilakshmi D

DOI: 10.5958/0974-360X.2017.00140.8         Access: Open Access Read More

Author(s): Mohd Yasir, Iti Chauhan, Misbahu J. Haji, Abdurazak J. Tura1, Prasoon K. Saxena

DOI: 10.5958/0974-360X.2018.00523.1         Access: Open Access Read More

Author(s): Praveen. K, Balamurugan. K

DOI: 10.5958/0974-360X.2020.00624.1         Access: Closed Access Read More

Author(s): Firoj Alam, Badruddeen, Anil Kumar Kharya, Akhtar Juber, Mohammad Irfan Khan

DOI: 10.5958/0974-360X.2020.00447.3         Access: Closed Access Read More

Author(s): Saminathan Kayarohanam, Vetriselvan Subramaniyan, Ashok Kumar Janakiraman, Madhan Kumar S. J

DOI: 10.5958/0974-360X.2019.00597.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags