Author(s): Jadhav Ankush P., Datar P.A., Kedar T.R., Kardile D.P., Shete R.V.

Email(s): jadhavbrand@gmail.com

DOI: 10.5958/0974-360X.2021.00175.X   

Address: Jadhav Ankush P.*, Datar P.A., Kedar T.R., Kardile D.P., Shete R.V.
Department of Pharmaceutical Quality Assurance, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor, Dist. Pune - 412 206 Maharashtra.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021


ABSTRACT:
A new, simple, accurate, precise and reproducible UV-Spectrophotometric method is being developed for the simultaneous estimation of ibuprofen and thiocolchicoside in tablet dosage form for first time. The stock solutions were prepared in methanol. The ?max for Thiocolchicoside and Ibuprofen were 256nm and 228nm respectively. The Thiocolchicoside, Ibuprofen obeyed Beer’s law in concentration range of 0.4-1.2µg/ml and 0.5-2.5µg/ml respectively. Results of analysis of absorbance ratio method were analysed and validated for various parameters according to ICH guidelines for accuracy, precision, linearity, robustness, LOD and LOQ. The proposed method is highly sensitive, precise and accurate, therefore can be used for intended purpose.


Cite this article:
Jadhav Ankush P., Datar P.A., Kedar T.R., Kardile D.P., Shete R.V.. Analytical Method Development and Validation of Thiocolchicoside and Ibuprofen in Tablet dosage form by UV-Spectrophotometry Method. Research J. Pharm. and Tech. 2021; 14(2):981-985. doi: 10.5958/0974-360X.2021.00175.X


REFERENCES:
1.    Chinna Raja et.al. New spectrophotometric methods for the determination of thiocolchicoside in bulk and pharmaceutical formulations. WJPPS. 2015; 4(5): 1158 -1167.
2.    Ankita Bhavsar et.al. Development and validation of UV-Visible spectrophotometric method for simultaneous estimation of ketoprofen and thiocolchicoside in solid oral dosage form. Int. Res. J. Pharm. 2016; 7(5): 53-58.
3.    Ramchandra Pandey et.al. Simultaneous estimation of etodolac and thiocolchicoside in bulk and in tablet formulation by UV-Spectrophotometry. Chem. Ind. Chem. Eng. Q. 2014; 20(1): 9-17.
4.    Hapse S. et.al. Difference spectrophotometric estimation and validation of ibuprofen from bulk and tablet dosage form. Der Pharmacia Lettre. 2011; 3(6): 18-23.
5.    Rupali Kirtawade et.al. Validated spectroscopic method for estimation of ibuprofen from tablet formulation. Arch Pharm Sci and Res. 2010; 2(1): 271-273.
6.    Rupali S. et.al. Development and validation of UV-Spectrophotometric methods for simultaneous estimation of Paracetamol and Ibuprofen in pure and tablet dosage form. Der Pharmacia Sinica. 2011; 2(3): 164-171.
7.    Rajan V. Rele and Rajesh N. Mali. Advance simultaneous determination of paracetamol, thiocolchicoside and aceclofenac in tablets by reverse phase high performance liquid chromatography. Der Pharmacia Sinica. 2014; 5(1): 34-39.
8.    Sunil R., Kanchan O. and Vidhya K Bhusari. Validated HPLC method for simultaneous estimation of paracetamol, aceclofenac and thiocolchicoside in bulk drug and formulation. RJPBCS. 2011; 2(2): 435-445.
9.    Santoshi G. and Annapurna et.al. Evaluation of A New Stability Indicating Method for the Determination of Aceclofenac and Thiocolchicoside in Pharmaceutical Dosage form by RP-HPLC, Orient. J. Chem. 2017; 33(3): 1337-1346.
10.    Yogita B. and Dipak D. A Stability Indicating RP-HPLC Method for Simultaneous Determination of Ibuprofen and Famotidine. Analytical Chemistry: An Indian Journal. 2016; 16(13): 1-16.
11.    Venkatakishore T. et.al. RP-HPLC method for simultaneous determination of ibuprofen and famotidine in pharmaceutical dosage form. WJPPS. 2016; 5(12): 1017-1025.
12.    Thakkalapally L. et.al. Validated RP-HPLC method for simultaneous determination of ibuprofen and pseudoephedrine in pharmaceutical formulation. Indo AJPR. 2019; 9(4): 1976-1986.
13.    Sasmita Kumari et.al. Spectrophotometric methods for the determination of thiocolchicoside in bulk and pharmaceutical dosage forms. J Pharm Edu Res. 2010; 1(1): 51-57.
14.    Choudhari V. et.al. Simultaneous spectrophotometric estimation of thiocolchicoside and diclofenac potassium B.P. in combined dosage form by ratio derivative and dual wavelength method. IJCR. 2010; 2(12): 1-10.
15.    Maheshwari D. et.al. Simultaneous estimation of Thiocolchicoside and Hydrochlorothiazide by Q-absorption ratio method. Int J Res Pharm Sci 2015; 5(1): 23-27.
16.    Rajan V. et.al. Simultaneous spectrophotometric estimation of Aceclofenac and Thiocolchicoside by second order derivative method in combined dosage form. J. Chem. Pharm. Res. 2015; 7(7): 1007-1012.
17.    Chaudhari Bharat et.al. Simultaneous spectrophotometric estimation of thiocolchicoside and dexketoprofen trometamol in pharmaceutical dosage form. IJBAR. 2012; 03(03): 179-183.
18.    Arvind. R. et.al. Simultaneous Estimation of Thiocolchicoside and Diclofenac Potassium by UV-Spectrophotometer Using Multicomponent Method. IJCRGG. 2011; 3(2): 944-947.
19.    Revankumar D. et.al. Simultaneous Estimation of Paracetamol, Thiocolchicoside and Aceclofenac by UV Spectrophotometer Using Multicomponent Mode Method. JPR. 2011; 4(7): 2297-2299.
20.    Rachmale P. et.al Development and Validation of UV-Spectrophotometric Methods for Simultaneous Determination of Ibuprofen and Tramadol in its Pure and Pharmaceutical Dosage Forms. IJPCS. 2013; 2(2): 656-662.
21.    S. Harshini et.al. Simultaneous estimation of paracetamol and ibuprofen in bulk and pharmaceutical dosage form by using UV- spectrophotometric method. IJIPSR. 2014; 2(8): 1854-1860.
22.    Gaikwad R. et.al. Development and Validation of Analytical Method for Simultaneous Estimation of Paracetamol and Ibuprofen Using UV-Visible Spectroscopy. IJPPR. 2017; 11(1): 389-396.
23.    Rupali Joshi et.al. Simultaneous Estimation of Paracetamol, Chlorzoxazone and Ibuprofen by Validated Spectrophotometric Methods. ACL 2 (2) 2012 pp 118 - 124.
24.    K.V. Nanda Kumar et.al. Simultaneous estimation of chlorzoxazone, paracetamol and ibuprofen by UV-Spectroscopic method. J Global Trends Pharm Sci. 2017; 8(1): 3721-3726.
25.    Rupali S. Joshi et.al. Development and validation of UV spectrophotometric methods for simultaneous estimation of Paracetamol and Ibuprofen in pure and tablet dosage form. Der Pharmacia Sinica. 2011; 2(3): 164-171.
26.    Yogita B. Development and validation of spectrophotometric methods for the estimation of ibuprofen and famotidine. Int J Pharm Pharm Sci. 2013; 5(3):358-363.
27.    KiranRathod and Jitendra Patel. Simultaneous Estimation of Etodolac and Thiocolchicoside in Their Combined Marketed Formulation by RP-HPLC. IJPTR. 2012; 4(4):1514-1519.
28.    Dr. Pillai and Deshmukh Nitin. RP-HPLC method for estimation of Etoricoxib and thiocolchicoside from tablet dosage form. WJPPS. 2011; 5(3):1499-1505.
29.    G. Abirami and Dr. T. Vetrichelvan. New RP-HPLC method for simultaneous estimation of thiocolchicoside and ketoprofen in tablet dosage form. WJPPS. 2015; 3(2):2564-2575.
30.    Sunil R., Kanchan O. and Vidhya K. Validated HPLC method for simultaneous estimation of paracetamol, aceclofenac and thiocolchicoside in bulk drug and formulation. RJPBCS. 2011; 2(2): 435-445.
31.    N. Sai, M. Prasadarao and G. Anil. Method development and validation of RP-HPLC for simultaneous estimation of etodolac and thiocolchicoside. WJPR. 2016; 7(7):1321-1330.
32.    Disha Palte and Dr. Avinash. Stability Studies in Combine Dosage form of Etoricoxib and Thiocolchicoside using RP-HPLC. IJRSB. 2015; 3(9): 163-170.
33.    Sohan S. et.al. Simultaneous estimation of Thiocolchicoside and Aceclofenac in pharmaceutical dosage form by spectrophotometric and LC method. Der Pharmacia Lettre. 2010; 2(2): 86-93.
34.    Dimal A. et.al. Development and Validation of Liquid Chromatographic Method for Estimation of Ibuprofen and Famotidine in Combined Dosage Form. International Scholarly Research Network ISRN Ana Chem. 2012. Article ID 674392:1-5.
35.    T. Venkatakishore et.al. RP-HPLC method for simultaneous determination of ibuprofen and famotidine in pharmaceutical dosage form. WJPPS. 2016; 5(12):1017-1025.
36.    Sovan P. et.al. Assay method development and validation of ibuprofen tablets by HPLC. Der Pharmacia Sinica. 2013; 4(4): 91-96.
37.    S. Ashutosh Kumar et.al. A new RP-HPLC stability indicating method development and validation for simultaneous estimation of ibuprofen and famotidine in bulk as well in pharmaceutical dosages form by using PDA detector. IJPSR. 2014; 5(9): 3829-3839.
38.    Narendra Nyola and Govinda Samy. Simultaneous Estimation of Ibuprofen and Famotidine in Pure and Combination Dosage Form by RP-HPLC. Journal of Applied Pharmaceutical Science. 2012; 02(05): 79-83.
39.    Yogita B. and Dipak D. A Stability Indicating RP-HPLC Method for Simultaneous Determination of Ibuprofen and Famotidine Analytical Chemistry: An Indian Journal Research. 2016; 16(13): 1-5.
40.    W. Sam et.al. Derivatized HPTLC method for simultaneous estimation of glucosamine and ibuprofen in tablets. JPRHC. 2010; 2(2): 156-162.

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