Author(s): Sugunakar, K. N. Maruthy, Jaffer, Srinivas, Priscilla Johnson


DOI: 10.5958/0974-360X.2021.00164.5   

Address: M.B.S. Sugunakar1, Dr. K. N. Maruthy2, Dr. Jaffer3, Dr. Srinivas4, Dr. Priscilla Johnson5*
1M.Sc (Ph.D. Scholar), G.S.L. Medical College, Rajahmundry, A.P.
2Prof., Narayana Medical College.
3M.D, Associate Professor G. S. L. Medical College RJY.
4 Prof and HOD, GSLMC.
5M.D, DNB, Ph.D. Professor, Department of Physiology, Sri Ramachandra Medical College and RI, Porur, Chennai.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021

The following study is conducted between three groups of subjects each group contains n=40 subjects. First the subjects were recruited to department of physiology for conducting study. Screening questionnaire was presented to the study subjects based on their responses according to the inclusion and exclusion criteria subjects were screened. The subjects who met the criteria’s for the study were recruited for the study and informed consent was obtained from the subjects after explaining the process of the study. The study questionnaire was given to the subject to collect the demographic, anthropometric data and socioeconomic status was evaluated by kuppuswami scale (1). The subjects were taken to the autonomic function testing lab in the department of physiology resting blood pressure was measured subject was connected to ECG apparatus to perform heart rate variability (HRV) analysis. The ECG data was acquired using audacity open source software. The data was analyzed using low pass filter at 40Hz and Accelerated pulse wave plethysmography was also obtained using APPG module with soundcard oscilloscope subsequent low pass filter 50Hz was applied and signal was analyzed angle was measured using image J software (2). Introduction: Accelerated photoplethysmography is a measurement tool which is used to evaluate "vascular retro gradation grade" and to detect "arteriosclerosis" by differentiating "volume capacity photoplethysmography" twice on fingertip (3) Aim: To evaluate the relationship between diastolic blood pressure and "arterial compliance" and "peripheral circulation status “using accelerated pulse wave plethysmography (APPG). Methodology: This study was conducted in healthy volunteers (n=40) and in hypertensive’s (n=120). Informed consent was obtained from the study participants and their blood pressure was recorded. Accelerated pulse wave plethysmography was obtained using APPG module with soundcard oscilloscope. Subsequent low pass filter 50Hz was applied and the signal was analyzed. The size of P1, P2, P3, the gradient of P1-P3 and the angle were measured and analyzed using image J software. Results: Rise in diastolic blood pressure leads to a shift in the angle between the P1 and P3 wave. Positive correlation was found between the diastolic blood pressure and the P1 P3 angular shift. (R= 0.2) and it was statistically significant (p <0 .05). Conclusion: This study indicates that rise in diastolic component of blood pressure is associated with more pronounced vascular changes which are detected as a shift in the angle of the APPG component. This non-invasive and cost-effective technique may pave way for early detection of vascular/cardiovascular disorders thereby preventing morbidity and mortality.

Cite this article:
Sugunakar, K. N. Maruthy, Jaffer, Srinivas, Priscilla Johnson. Accelerated Pulse Wave Photo Plethysmography – A Marker of Vascular Compliance and cardiac autonomic functions. Research J. Pharm. and Tech. 2021; 14(2):921-924. doi: 10.5958/0974-360X.2021.00164.5

1.    Bairwa M, Rajput M, Sachdeva S. Modified Kuppuswamy’s Socioeconomic Scale: Social Researcher Should Include Updated Income Criteria, 2012. Indian J Community Med [Internet]. 2013 Jul;38(3):185–6. Available from: 24019607
2.    Mahesh Kumar K, Dilara K, Maruthy KN, Sundareswaren L. Validation of PC–based sound card with biopac for digitalization of ECG recording in short–term HRV analysis. N Am J Med Sci. 2016;8(7): 307–11.
3.    Allen J. Photoplethysmography and its application in clinical physiological measurement. Physiol Meas. 2007; 28(3): 1–39.
4.    Koyanagi S, Eastham C, Marcus ML. Effects of chronic hypertension and left ventricular hypertrophy on the incidence of sudden cardiac death after coronary artery occlusion in conscious dogs. Circulation. 1982;65(6): 1192–7.
5.    World Health Organization. Global Atlas on Cardiovascular Disease Prevention and Control. Policies, Strategies and Interventions. Iraq. 2011;164.
6.    Sevre K, Lefrandt JD, Nordby G, Os I, Mulder M, Gans ROB, et al. Autonomic function in hypertensive and normotensive subjects: The importance of gender. Hypertension. 2001; 37(6): 1351–6.
7.    Elgendi M, Fletcher R, Liang Y, Howard N, Lovell NH, Abbott D, et al. The use of photoplethysmography for assessing hypertension. npj Digit Med [Internet]. 2019; 2(1):1–11. Available from:
8.    Lee Y, Shin H, Choi HJ, Kim C. Can pulse check by the photoplethysmography sensor on a smart watch replace carotid artery palpation during cardiopulmonary resuscitation in cardiac arrest patients? A prospective observational diagnostic accuracy study. BMJ Open. 2019;9(2): 1–5.
9.    Gonçalves H, Pinto P, Silva M, Ayres-de-Campos D, Bernardes J. Electrocardiography versus photoplethysmography in assessment of maternal heart rate variability during labor. Springerplus. 2016; 5(1).
10.    Jeyhani V, Mahdiani S, Peltokangas M, Vehkaoja A. Comparison of HRV parameters derived from photoplethysmography and electrocardiography signals. Proc Annu Int Conf IEEE Eng Med Biol Soc EMBS. 2015;2015-Novem: 5952–5.
11.    Liu M, Po L-M, Fu H. Cuffless Blood Pressure Estimation Based on Photoplethysmography Signal and Its Second Derivative. Int J Comput Theory Eng. 2017;9(3): 202–6.
12.    Fenning RS, Burgert ME, Hamamdzic D, Peyster EG, Mohler ER, Kangovi S, et al. Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2. J Am Heart Assoc. 2015;4(2): 1–12.
13.    Schroeder EB, Liao D, Chambless LE, Prineas RJ, Evans GW, Heiss G. Hypertension, Blood Pressure, and Heart Rate Variability: The Atherosclerosis Risk in Communities (ARIC) Study. Hypertension. 2003;42(6): 1106–11.

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