Author(s): Smita Kumbhar, Vinod Matole, Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar

Email(s): matole7414@gmail.com

DOI: 10.5958/0974-360X.2021.00161.X   

Address: Smita Kumbhar, Vinod Matole*, Dr. Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar
D.S.T.S. Mandal’s College of Pharmacy, Solapur-413004.Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021


ABSTRACT:
Objective: The present research has been undertaken for the formulation and evaluation of lignocaine hydrochloride gel. It is used for topical use for the local anaesthetic activity. Methods: Carbopol 934 was used as a polymer in various batches. The ratio of Carbopol 934 was changed for various batches. Developed Formulations of Physicochemical parameters such as percentage yield, drug content, pH, Viscosity, Spreadability, Extrudability and In-vitro Diffusion study were carried out for developed batches of Lignocaine Hydrochloride. Results: Viscosity studies of various formulations Exhibited that Formulation F2 was better than that of F1 and F3. From among all the developed formulation, F2 Shows better rheological properties and excellent Extrudability. pH of the F2 Batch is Sufficient to treat the pain. Percentage yield and drug content of F2 batch is good than other batches. Results shows that the concentration of Carbopol 934 gives the good rheological properties and drug contents. In-vitro Diffusion studies were carried out, F2 batch shows better results than that of the other two batches i.e. 96.06%. Conclusion: It was concluded that F2 batch is the good than the other batches. So F2 batch is good for the topical use.


Cite this article:
Smita Kumbhar, Vinod Matole, Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar. Formulation and Evaluation of Lignocaine Hydrochloride Topical gel. Research J. Pharm. and Tech. 2021; 14(2):908-910. doi: 10.5958/0974-360X.2021.00161.X


REFERENCES:
1.    Pandit A, Pol V, Kulkarni V. Xyloglucan Based In-Situ Gel of Lidocaine HCl for the Treatment of Periodontosis. Journal of Pharmaceutics 2016;1(1):1-9.
2.    https://en.wikipedia.org/wiki/Lidocaine.
3.    Tektook N, Ali A. Lidocaine Hydrochloride (Local). The American Society of Health-System Pharmacists 2015;2(1):123-129.
4.    Hasan F, Ali A. (Lidocaine Hydrochloride (Antiarrhythmic). The American Society of Health-System Pharmacists 2015;12(3):156-165.
5.    Mitkari B, Korde S, Mahadik K. Formulation and evaluation of topical liposomal gel for fluconazole. Indian Journal of Pharmaceutical Education 2014;44(4):324-333.
6.    Kasar P, Phadtare D, Kale K. Formulation ad evaluation of Antifungal gel containing Itraconazole. International Journal of Current Pharmaceutical Research 2018;10(4):71-74.
7.    Basha B, Prakasam K, Goli D. Formulation and evaluation of gel containing fluconazole antifungal agent. International Journal of Drug Development and Research 2011;3(4):109-128.

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