Author(s):
Amaq Fadholly, Arif N. M. Ansori, Viol D. Kharisma, Jola Rahmahani, Martia R. Tacharina
Email(s):
martia.rt@fkh.unair.ac.id
DOI:
10.5958/0974-360X.2021.00157.8 
Address:
Amaq Fadholly1, Arif N. M. Ansori1, Viol D. Kharisma2, Jola Rahmahani3, Martia R. Tacharina3*
1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga,Surabaya, Indonesia.
2Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia.
3Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga,Surabaya, Indonesia.
*Corresponding Author
Published In:
Volume - 14,
Issue - 2,
Year - 2021
ABSTRACT:
The purpose of this study was to analyze the genomic information of the glycoprotein gene of rabies virus (RABV) in several countries of Asia. The genomics information of vaccine virus strain and some local isolates were retrieved from GeneBank® (National Center for Biotechnology Information, USA). Ten genomics informations are consist of ERA vaccine virus, two viruses from Indonesia, a virus from Myanmar, India, Nepal, South Korea, Japan, Sri Lanka, and Iran. This bioinformatics process the ten genomics data in order to find pattern in 1,575 bp of glycoprotein gene of RABV. In conclusion, this study have revealed the data of homology, B-cell epitope prediction, genetic distance, and molecular phylogenic analysis of RABV in various countries of Asia. We indicated that the glycoprotein, the immunogenic surface protein of RABV, has important part for vaccine design.
Cite this article:
Amaq Fadholly, Arif N. M. Ansori, Viol D. Kharisma, Jola Rahmahani, Martia R. Tacharina. Immunobioinformatics of Rabies Virus in Various Countries of Asia: Glycoprotein Gene. Research J. Pharm. and Tech. 2021; 14(2):883-886. doi: 10.5958/0974-360X.2021.00157.8
Cite(Electronic):
Amaq Fadholly, Arif N. M. Ansori, Viol D. Kharisma, Jola Rahmahani, Martia R. Tacharina. Immunobioinformatics of Rabies Virus in Various Countries of Asia: Glycoprotein Gene. Research J. Pharm. and Tech. 2021; 14(2):883-886. doi: 10.5958/0974-360X.2021.00157.8 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-2-53
REFERENCES:
1. Fisher CR, Streicker DG, Schnell MJ. The spread and evolution of rabies virus: conquering new frontiers. Nature Review Microbiology. 2018; 16: 241-255.
2. Fooks AR, Cliquet F, Finke S, Freuling C, Hemachudha T, Mani RS, Müller T, Nadin-Davis S, Picard-Meyer E, Wilde H, Banyard AC. Rabies. Nature Reviews Disease Promers. 2017; 3: 17091.
3. Warrell MJ. The dillema of managing human rabies encephalitis. Trop Med Int Health. 2016; 21: 456-457.
4. Tenzin, Ward MP. Review of rabies epidemiology and control in south, south east and east asia: past, present and prospects for elimination. Zoonoses and Public Health. 2012; 59(7): 451-467.
5. Gongal G, Wright AE. Human rabies in the WHO Southeast Asia Region: Foward Steps for Elimination. Adv Prev Med. 2011; Article ID 383870.
6. El-Sayed A. Advances in rabies prophylaxis and treatment with emphasis on immunoresponses mechanisms. Int J Vet Sci Med. 2018; 6(1): 8-15.
7. Hicks D, Fooks A, Johnson N. Developments in rabbies vaccines. Clin Exp Immunol. 2012; 169: 199-204.
8. Yang D, Kim H, Lee W, Song J. The present and future of rabies vaccine in animals. Clin Exp Vaccine Res. 2013; 2(1): 19-25.
9. Banyard AC, Fooks AR. The impact of novel lyssavirus discovery. Microbiol Australia. 2017; 38: 18-21.
10. Jespersen MC, Mahajan S, Peters B, Nielsen M, Marctili P. Antibody spesific B-cell epitope predictions: leveraging information from antibody-antigen protein complexes. Front Immunol. 2019; 10: 298.
11. Sanchez-Trincando JL, Gomez-Perosanz M, Reche PA. Fundamentals and methods for T-and B-cell epitope prediction. J Immunol Res. 2017; 2680160.
12. Marston DA, Horton DL, Nunez J, Ellis RJ, Orton RJ, Johnson N, Banyard AC, McElhinney LM, Freuling CM, Firat M, Ünal N, Müller T, Lamballerie X, Fooks AR, Genetic of analysis of a rabies virus host shift event reveals within-host viral dynamics in a new host. Virus Evol. 2017; 3(2): vex038.
13. Rahmahani J, Suwarno S, Yuniarti WM, Rantam FA. Antigenic site of nucleoprotein gene from Indonesian rabies virus isolates. Veterinary World. 2019;12(5): 724-728.
14. Yousaf MZ, Qasim M, Zia S, Khan MR, Ashfaq UA, Khan S. Rabies molecular virology, diagnosis, prevention and treatment. Virology Journal. 2012; 9(50).
15. Doytchinova IA, Flower DR. Vaxijen: a server for prediction of protective antigens, tumour antigens and subunit vaccines. BMC Bioinformatics. 2007; 8: 4.