Author(s): Venkatesh Kamath B, Hawa Hashim, Kamesh Kumar Keshri, Swati Tripathy, Subrahmanyam. V. M

Email(s): vm.subra@manipal.edu

DOI: 10.5958/0974-360X.2021.00149.9   

Address: Venkatesh Kamath B1, Hawa Hashim2, Kamesh Kumar Keshri2, Swati Tripathy3, Subrahmanyam. V. M1
1Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education. Manipal – 576104.
2Final Year BPharm Students, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education. Manipal – 576104.
3PG Student, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021


ABSTRACT:
Keratinase is a protease enzyme. It degrades the keratin protein present in the hair, skin, nails etc. It can be applied in various fields of therapeutics such as in the treatment of onychomycosis, hair dandruff and recently in skin cancer as well. It can also be applied in various textile and leather industries. The SPF1 fungi isolated from the poultry farm around Manipal, India was found to produce the inducible keratinase enzyme. The strain was exposed to UV radiation to induce the UV mutation and the yield was found to have improved from 147.52µg/ml to 288.00µg/ml. The SPF1 strain was also plated in Sabouraud Dextrose Agar and 8 different colonies were selected to compare their keratinolytic activities.


Cite this article:
Venkatesh Kamath B, Hawa Hashim, Kamesh Kumar Keshri, Swati Tripathy, Subrahmanyam. V. M. Strain improvement of a new Keratinolytic Fungi. Research J. Pharm. and Tech. 2021; 14(2):843-845. doi: 10.5958/0974-360X.2021.00149.9


REFERENCES:
1.    Itisha Singh, R. K. S. Kushwaha. Keratinases and microbial degradation of Keratin. Adv. Appl. Sci. Res. 2015; 6(2):74-82.
2.    Beti Vidmar and Maša Vodovnik. Microbial Keratinases: Enzymes with Promising Biotechnological Applications. Food Technol Biotechnol. 2018; 56(3): 312–328.
3.    Gupta R, Ramnani P. Microbial keratinases and their prospective applications: an overview. Appl Microbiol Biotechnol. 2006;70(1):21-33.
4.    Veslava Matikevicience, Danute Masiliunience, Saulius Grigiskis. Degradation of keratin containing wastes by Bacteria with keratinolytic activity, Environment Technology Resources, 2009; 01:284-289.

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Author(s): Venkatesh Kamath B, Hawa Hashim, Kamesh Kumar Keshri, Swati Tripathy, Subrahmanyam. V. M

DOI: 10.5958/0974-360X.2021.00149.9         Access: Closed Access Read More

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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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