Sugunadevi Govindasamy, Suresh Kathiresan
Sugunadevi Govindasamy1, Suresh Kathiresan2
1Assistant Professor and Head, Department of Biochemistry, Dhanalakshmi Srinivasan College of Arts and Science for Women (Autonomous), Perambalur -621212.
2Associate Professor, Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar.
Volume - 14,
Issue - 2,
Year - 2021
The present study was investigated to judge the immune histochemical expression of inflammatory and angiogenic markers in DMBA induced hamster buccal pouch carcinogenesis. a complete variety of 24 golden Syrian hamsters were randomized into randomised into four teams of six animals in each. Group I animals were served as untreated control. Groups II and III animals were painted with 0.5% DMBA in liquid paraffin three times per week for 14 weeks on the left buccal pouches. Group III animals were orally administered with Mosinone-A (2mg kg-1 b.wt) starting one week before the exposure to the carcinogen and continued on days alternate to DMBA painting, until the sacrification of the animals. Group IV animals were received Mosinone-A alone throughout the experimental period. Topical application of DMBA for 14 weeks induced buccal pouch carcinomas associated with increased expression of, cytokeratin-8 and iNos where as decreased expression of Cytokeratin. Oral administration of Mosinone-A significantly inhibited the development of HBP carcinomas as revealed by decreased expression of, Cytokeratin-8 and iNos increased expression Cytokeratin. The result of this present study indicates that Mosinone-A will exerts protective effects against DMBA induced buccal pouch carcinogenesis. These findings counsel that Mosinone-A exerts its malignant neoplasm properties by inhibiting cell proliferation and inducement differentiation and caspase mediated cell death.
Cite this article:
Sugunadevi Govindasamy, Suresh Kathiresan. Inhibitory Effect of Mosinone - A on Immunohistochemical Expression of Inflammatory and Angiogenic markers in 7,12-dimethylbenz (a) Anthracene induced Hamster Buccal Pouch Carcinogenesis. Research J. Pharm. and Tech. 2021; 14(2):833-837. doi: 10.5958/0974-360X.2021.00147.5
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