Author(s):
M Vijay Harsha, Srinivasa Rao Baratam, A Krishna Kishore
Email(s):
srinivas.baratam077@gmail.com
DOI:
10.5958/0974-360X.2021.00144.X
Address:
M Vijay Harsha, Srinivasa Rao Baratam*, A Krishna Kishore
St. Ann’s College of Pharmacy, Department of Pharmaceutics, Andhra University Cantonment,
Vizianagaram, Andhra Pradesh, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 2,
Year - 2021
ABSTRACT:
Background: The main objective of this work is to formulate a sustained release matrix tablets using neem gum. Ketoprofen was selected as a model drug due to the low biological half life, it requires frequent administration. Hence sustained dosage forms are formulated to reduce the dosage frequency. Methods: Ketoprofen matrix tablets were formulated by employing neem gum as a release rate retardant material and used in 10%, 20%, 30%, and 40% Concentration levels. Wet granulation method was used to develop sustained release tablets. Results: Tablet was evaluated in terms of flow properties of blended powders and the average weight, drug content hardness, in vitro dissolution studies and fourier transformation-infrared spectroscopy (FT-IR) were determined. Drug release was evaluated with zero and the first order for release kinetics, Higuchi, Korsmeyer peppas models for the release mechanism. The hardness of the tablets ranged from 5 to 7 Kg/cm2 and the friability values were less than 1% indicating that the matrix tablets were compact and hard. All the formulations satisfied the content of the drug as they contained 99.1 to 100.8 % of Ketoprofen, KNS3 released 99.2 of drug in 12 hours and KNS4 released 90.13% of drug in 12 hours using neem gum and This data reveals that drug release follows fickian diffusion mechanism Peppas model. Conclusion: The present study could establish the suitability of neem gum as Controlled released (CR) polymer in the design of matrix tablets.
Cite this article:
M Vijay Harsha, Srinivasa Rao Baratam, A Krishna Kishore. Development and Evaluation of Ketoprofen Sustained delivery system using Neem Gum. doi: 10.5958/0974-360X.2021.00144.X
Cite(Electronic):
M Vijay Harsha, Srinivasa Rao Baratam, A Krishna Kishore. Development and Evaluation of Ketoprofen Sustained delivery system using Neem Gum. doi: 10.5958/0974-360X.2021.00144.X Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-2-40
REFERENCES:
1. Lam KS. New aspects of natural products in drug discovery. Trends Microbiol. 2007;15(6): 279-89.
2. McChesney JD, Venkataraman SK, Henri JT. Plant natural products: back to the future or into extinction. Phytochem. 2007;68(14): 2015-22.
3. Joshi Y, Chaudhary RK, Teotia UVS. Formulation and evaluation of diclofenac sodium sustained release matrix tablets using aegle marmelos gum. Int J Curr Trends Pharm Res. 2013; 1(3): 174–80
4. Sharada B, Basavaraj BV, Bharath S, Deveswaran R, Madhavan V. Sustained release matrix tablets of indomethacin using hibiscus rosa-sinensis as release retardant. Schol Res Libr. 2012; 4: 227–33.
5. Khan J, Yuen KH, Bee Hong N, Chitneni M Elhassan, GO, Al-Dhali S, Kaleemullah M. Preparation and in vitro evaluation of different controlled release polymeric matrices containing ketoprofen. Health Med. 2010; 4(2): 386–92.
6. Pandey R, Khuller GK. Polymer based drug delivery systems for mycobacterial infections. Curr Drug Deliv. 2004;1: 195-201.
7. Chamarthy SP, Pinal R. Plasticizer concentration and the performance of a diffusion controlled polymeric drug delivery system. Colloids Surf A Physio chem Eng Asp. 2008;331: 25-30.
8. Alonso-Sande M, Teijeiro OD, Remunan-Lopez C, Alonso MJ. Glucomannan, a promising polysaccharide for biopharmaceutical purposes. Eur J Pharm Biopharm 2008;72(2): 453-62.
9. Liversidge GG. Ketoprofen. Analytical profiles of drug substances. 1981; 10: 443-71.
10. Shohin IE, Kulinich JI, Ramenskaya GV, Vasilenko GF. Evaluation of in vitro equivalence for drugs containing BCS class II compound ketoprofen. Dissolution Technol.2011; 26–9.
11. Abayomi T, Ogunjimi, Gbenga A. Neem Gum as a Binder in a Formulated Paracetamol Tablet with Reference to Acacia Gum BP. AAPS Pharm Sci Tech.2014; 15(2): 500-10.
12. Nayanmoni B, Hemanta KS. Formulation and Evaluation of Controlled Release Herbal Mosquito Repellent Gel Containing Encapsulated Essential Oils Obtained from Natural Sources Indigenous to Northeast India. Asian J Pharm. 2019;13(1): 23-32.
13. Dhanalakshmi S, Baratam SR. Design and Evaluation of Zolpidem Tartrate Matrix Tablets for Extended Release Using Natural Gums and HPMC K100M. J App Pharm Sci. 2018; 8(7): 072-7.
14. Chowdary KPR, Rao KSP. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin-Poloxamer 407-PVP K30: A Factorial Study. Der Pharmacia Lettre. 2011; 3(6): 24-30.
15. Singh I, Kumar P. Preformulation studies for direct compression suitability of cefuroxime axetil and paracetamol: a graphical representation using sedem diagram. Acta Pol Pharm. 2012;69(1): 87-93.