Author(s): Mohammad Sukmanadi, Mustofa Helmi Effendi


DOI: 10.5958/0974-360X.2021.00143.8   

Address: Mohammad Sukmanadi1, Mustofa Helmi Effendi2*
1Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
2Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021

Background: Interaction bioinformatics analysis research and prediction of protein gene panel identification as a target of evaluating the effects of damage by AFB1 that induces hepatic injury1. Capsaicin compounds are active2: 1). Activating apoptosis, 2). Inducing the cell cycle, 3). cell-regulation viability of transcription expression factors. Objective: Proving that capsaicin inhibits the expression of AKT1 and MAPK1 target proteins in mice due to the induction of AFB1 in silico and in vivo. Methods: Molecular docking (In silico) bioinformatics and hepatic lesions pathogenicity; congestion, degeneration, and necrosis (In vivo). Results: Molecular docking of Gibbs free energy is negative. Scoring synergistically inhibits the viability of the signaling pathway and prevents the occurrence of hepatic lesions. Conclusion: Capsaicin has been shown to have a protective effect against AFB-1 induction; by preventing the occurrence of hepatic lesions so that they have potential herbal medicine candidates as hepatoprotection.

Cite this article:
Mohammad Sukmanadi, Mustofa Helmi Effendi. The protective effect of Capsaicin (Capsicum annum L) against the induction of Aflatoxin B1 in hepatocytes: A study of liver Histopathology in mice (Mus musculus). Research J. Pharm. and Tech. 2021; 14(2):813-816. doi: 10.5958/0974-360X.2021.00143.8

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2.    Lin CH, Lu WC, Wang CW, Chan YC, Chen MK. 2013. Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complementary and Alternative Medicine. 13:1472- 6882.doi:10.1186/1472-6882-13-46.
3.    Gürbay A, Aydın S, Girgin G, Engin AB, Şahin G. Assessment of Aflatoxin M1 Levels in Milk in Ankara, Turkey. Food Control 2006; 17 (1): 1–4.
4.    Hussain, I., Anwar, J., Munawar, M. A., and Asi, M. R. 2008. Variation of Levels of Aflatoxin M1 In Raw Milk from Different Localities in The Central Areas of Punjab, Pakistan. Food Control, 19(12), 1126-1129.
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11.    Kharisma, Viol Dhea, Luhur Septiadi, and Syafrudin Syafrudin. 2018. Prediction of Novel Bioactive Compound from Zingiber officinale as Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) of HIV-1 through Computational Study. Bioinformatics and Biomedical Research Journal 1. 2: 49-55
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