Author(s): P. R. Mahaparale, V. P. Thorat

Email(s): pareshmahaparale@gmail.com

DOI: 10.5958/0974-360X.2021.00142.6   

Address: P. R. Mahaparale1*, V. P. Thorat2
1Government College of Pharmacy, Osmanpura Aurangabad, Maharashtra 431005.
2Siddhi College of Pharmacy Chikhali, Pune, Maharashtra 411062.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021


ABSTRACT:
Leflunomide is a Non-steroidal Anti-Inflammatory drug, which is poorly water soluble. In present study attempt has been made to prepare and characterize inclusion complexes of drug with Beta Cyclodextrin (?-CD). The phase solubility analysis indicated the formation of a 1:1 molar inclusion complex of drug with ?-CD. Apparent stability constant (KC) was 674 K-1 for ?-CD complex. The inclusion complexes were prepared by three different methods viz. coprecipitation, kneading and microwave irradiation method. The prepared complexes were characterized using dissolution study, FTIR and X-ray diffractometry. The inclusion complex prepared with ?-CD by kneading method exhibited greatest enhancement in solubility (18 mg/100ml) and fastest dissolution (T90 = 29 min.) of Leflunomide.


Cite this article:
P. R. Mahaparale, V. P. Thorat. Enhancement of Solubility of Leflunomide with -cyclodextrin inclusion complexation. Research J. Pharm. and Tech. 2021; 14(2):809-812. doi: 10.5958/0974-360X.2021.00142.6


REFERENCE:
1.    Reynolds, J. E. F., Eds., In; Martindale The Extra Pharmacopeia, 31st Edn., Pharmaceutical Press, London, 2002, 711-712, 53-55.
2.    Budawari, S., The Merck Index, 13th Edn., Merck and Co., Inc., Whitehouse, NJ, 2003, 971.
3.    Loftsson T., Brewster M. E. and Masson M., Role of cyclodextrins in improving oral drug delivery, Am. J. Drug Deliv. 2004; 2: 1-15.
4.    Deshmukh S. S., Potnis V. V., Shelar D. B. and Mahaparale P. R., Studies on inclusion complexes of ziprasidone hydrochloride. With β –cyclodextrin and hydroxypropyl β –cyclodextrin, Indian Drugs, 2007; 677-682.
5.    Mahaparale P. R., Malpure P. S., Sanap D. A., Kachare V. T. and Kasture P. V., Development of dissolution medium of leflunomide, The Indian Pharmacist, April 2007; 69- 70.
6.    Reddy M. N., Chowdary K. P. R. and Diwan P. V., β -cyclodextrin complexes of celecoxib: molecular modeling, characterization and dissolution studies, AAPS Pharm. Sci., 2004; 6 (1); article 7.
7.    Higuchi T., Connors K. A., Phase solubility techniques, Adv. Anal. Chem. Instr., 1965; 4: 117- 212.
8.    Martin E. M., Cyclodextrin and their uses: A Review, Process Biochemistry, 2003; 30:5-7
9.    Aulton M. E, The science of dosage form design, II edition, Churchill Livingstone, 2002; 16: 23, 234.
10.    Preeti V. Bankar, Improved Dissolution Rate of Leflunomide using Hydroxypropyl-β-Cyclodextrin Inclusion Complexation by Freeze-Drying Method, International Journal of Drug Delivery, 2012; 4:498-506.
11.    Kane R. N., Kuchekar B. S., Preparation, physicochemical characterization, dissolution and formulation studies of Telmisartan Cyclodextrin inclusion complexes, Asian J. Pharm., 2010; 4:2-9.
12.    Pandya P., Pandey N., Singh S. K., Kumar M. Formulation and characterization of ternary complex of poorly soluble duloxetine hydrochloride. Journal of Applied Pharmaceutical Science, 2015; 5 (06) : 088-096.
13.    Pradeep R. Vavia, Inclusion Complexation of Nimesulide with beta-Cyclodextrins, Drug Development and Industrial Pharmacy, 1999; 25(4):543–545.

Recomonded Articles:

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Fathima Mariyam Niyas

DOI: 10.5958/0974-360X.2015.00182.1         Access: Open Access Read More

Author(s): Bharti Ahirwar, Dheeraj Ahirwar, Alpana Ram

DOI:         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Author(s): DK Golwala, LD Patel, SB Bothara, SK Vaidya, AR Sahu, S Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora

DOI: Not Available         Access: Open Access Read More

Author(s): Gopinath G, Thirumal M, P. R. Kumar

DOI: 10.5958/0974-360X.2020.00362.5         Access: Closed Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags