Saumya Das, A.V Jithan, C. Raghunadha Guptha, Dharmajit Pattanayak
Saumya Das1, A.V Jithan2, C. Raghunadha Guptha3, Dharmajit Pattanayak1
1Bengal School of Technology, Sugandha, West Bengal.
2Omega College of Pharmacy, Hyderabad.
3Pellets Pharma Ltd, Hyderabad.
Volume - 14,
Issue - 2,
Year - 2021
The aim of the present study was to develop and characterized a vesicular drug carrier system (proliposome) for oral delivery of metformin hydrochloride to overcome the problems related with conventional drug delivery system. Proliposomes of metformin hydrochloride were prepared by spray gun technique by varying the composition drug and excipiets. Proliposome formulations were characterized for compatibility, Vesicle size, % Drug content, % Entrapment efficiency, Surface morphology, Surface charge, in vitro drug release and stability studies. The proliposomal dry powder was prepared for optimized proliposomal formulation MPF9. Drug and physical mixture were characterized by FTIR, the result of FTIR study showed that no interaction between drug and polymers and other formulation parameters of formulated proliposomes and proliposomal dry powder are evaluated which showed better results.
Cite this article:
Saumya Das, A.V Jithan, C. Raghunadha Guptha, Dharmajit Pattanayak. Proliposome Technique for Enhancement of Bioavailability of Metformin Hydrochloride. Research J. Pharm. and Tech. 2021; 14(2):747-751. doi: 10.5958/0974-360X.2021.00130.X
1. Sahoo CK, Bhanja S, Panigrahy UP, Panda KC, Sahoo N. Approaches in the treatment of diabetes mellitus. Int J Med Lab Res, 2016; 1(2): 29-37.
2. Hiremath PS, Soppimath KS, Betageri GV. Proliposomes of exemestane for improved oral delivery: formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine. Int J Pharm 2009; 380: 96-104.
3. Sun C, Wang J, Liu J, Qiu L, Zhang W, et al. Liquid proliposomes of nimodipine drug delivery system: preparation, characterization, and pharmacokinetics. Aaps Phar 2013;14: 332-338.
4. Yadav A, Murthy MS, Shete AS, Sakhare S. Stability aspects of liposomes. Ind J Pha Edu 2011; 45: 402-413.
5. Sahoo CK, Sahoo PK, Sahoo TK, Mohanty DL, satyanarayana K, Nayak PK. Advances in liposomal drug delivery system: a review. Pharmanest An International Journal of Advances in Pharmaceutical Sciences. 2014; 5(3):2019-2033.
6. Payne NI, Timmins P, Ambrose CV, Ward MD, Ridgway F (1986) Proliposomes: a novel solution to an old problem. J Pha Sc. 75: 325-329.
7. Manjula D, Shabaraya AR, Shyale S. Topical Delivery of Fenoprofen Proliposomes: Preparation, Evaluation and In Vitro Release. Int J Pha Sc. In 2014; 3: 06-12.
8. Janga KY, Jukanti R, Velpula A, Sunkavalli S, Bandari S, et al. Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge. Eur J Phar Bio 2012; 80: 347-357.
9. Song KH, Chung SJ, Shim CK. Preparation and evaluation of proliposomes containing salmon calcitonin. J Con Rel 2002; 84: 27-37.
10. Janga KY, Jukanti R, Velpula A, Sunkavalli S, Bandari S, et al. Bioavailability enhancement of zaleplon via proliposomes: Role of surface charge. Euro J Phar Biop 2012; 80: 347-357.