Ranitidine HCl is one group of H2-blockers that is normally used for the therapy of upper digestive tract. Ranitidine absorption occurs only in the gastric and initial part of intestine. In addition, ranitidine also undergoes metabolism in the colon, therefore it has a low bioavailability. According to that, a drug delivery system that maintains preparation in the gastric to increase absorption in the gastric in order to increase bioavailability is needed. The tablet was made using wet granulation method with HPMC K15M as the matrix by adding ethyl cellulose 10 cps to inhibit the release of ranitidine. This is because as a drug, HPMC K15M will increase the release of ranitidine HCl. The tablet produced was evaluated for its floating property and release using the medium of HCl 0.1N at 370C for 8 hours using type II dissolution test equipment. The test results proved that the tablet produced has a good floating property and with a decrease in the concentration of ethyl cellulose, it will increase the release of ranitidine HCl.
Cite this article:
Unun Faiz Su'udiyah, Sugiyartono. The Effect of Ethyl Cellulose 10 Cps on the floating Characteristic and Ranitidine HCL release from floating Tablet (using HPMC K15M Matrix). Research J. Pharm. and Tech. 2021; 14(2):735-740. doi: 10.5958/0974-360X.2021.00128.1
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