Aya Alabdali, Marwah Kzar, Sasikala Chinnappan, Mogana R, Shaik Ibrahim Khalivulla, Rahman H, Basma M. Abd Razik
email@example.com , firstname.lastname@example.org
Aya Alabdali1, Marwah Kzar2, Sasikala Chinnappan3*, Mogana R4, Shaik Ibrahim Khalivulla5, Rahman H6, Basma M. Abd Razik7
1,2The University of Mashreq, College of Pharmacy, Baghdad, Iraq.
3, 4, 5Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No.1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur, Malaysia.
6PSG College of Pharmacy, Coimbatore, India.
7College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Volume - 14,
Issue - 12,
Year - 2021
In the past few years, multiple drugs have been produced from traditional raw materials and recent pandemic disease COVID-19 once again research on this matter is being conducted to determine potential therapeutic purposes of different Ayurvedic Indian medicines and herbs. One such medicinal herb is Curcuma longa. Curcumin is strong antioxidant, anti-inflammatory, antispasmodic, antiangiogenic, anti-carcinogenic, as shown by multiple in vitro and in vivo studies. The action of the growth factor receptors is inhibited by curcumin. The anti-inflammatory effect of curcumin is obtained on the cytokines, proteolytic enzymes, eicosanoids, and lipid mediators. The superoxide radicals, nitric oxide and hydrogen peroxide, are sifted by curcumin, while lipid peroxidation is inhibited. Such properties of the compound thus form the foundation for its various therapeutic and pharmacological effects could also hold antiviral properties including COVID-19. The aim of this research is to summarize the updated pharmacological activities of curcumin.
Cite this article:
Aya Alabdali, Marwah Kzar, Sasikala Chinnappan, Mogana R, Shaik Ibrahim Khalivulla, Rahman H, Basma M. Abd Razik. Antioxidant activity of Curcumin. Research Journal of Pharmacy and Technology. 2021; 14(12):6741-6. doi: 10.52711/0974-360X.2021.01164
Aya Alabdali, Marwah Kzar, Sasikala Chinnappan, Mogana R, Shaik Ibrahim Khalivulla, Rahman H, Basma M. Abd Razik. Antioxidant activity of Curcumin. Research Journal of Pharmacy and Technology. 2021; 14(12):6741-6. doi: 10.52711/0974-360X.2021.01164 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-94
1. Akram M, Shahab-Uddin AA, Usmanghani K, Hannan A, Mohiuddin E, Asif M. Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol. 2010; 55(2):65-70.
2. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. CURCUMIN: THE INDIAN SOLID GOLD. In: Aggarwal BB, Surh Y-J, Shishodia S, editors. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Boston, MA: Springer US; 2007. p. 1-75.
3. Karatepe O, Acet E, Battal M, Adas G, Kemik A, Altiok M, et al. Effects of glutamine and curcumin on bacterial translocation in jaundiced rats. World journal of gastroenterology: WJG. 2010; 16(34):4313.
4. Brunt EM. Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2010; 7(4):195-203.
5. Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clinical Gastroenterology and Hepatology. 2006; 4(12):1502-6.
6. Sundar V, Kumar KAS, Manickam V, Ramasamy T. Current trends in pharmacological approaches for treatment and management of acute pancreatitis–a review. Journal of Pharmacy and Pharmacology. 2020.
7. Yu Y, Wu S, Li J, Wang R, Xie X, Yu X, et al. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metabolic brain disease. 2015; 30(1):47-55.
8. Akbik D, Ghadiri M, Chrzanowski W, Rohanizadeh R. Curcumin as a wound healing agent. Life sciences. 2014; 116(1):1-7.
9. Gopinath D, Ahmed MR, Gomathi K, Chitra K, Sehgal P, Jayakumar R. Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials. 2004; 25(10):1911-7.
10. Panchatcharam M, Miriyala S, Gayathri VS, Suguna L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Molecular and cellular biochemistry. 2006; 290(1-2):87-96.
11. Sidhu GS, Mani H, Gaddipati JP, Singh AK, Seth P, Banaudha KK, et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair and Regeneration. 1999; 7(5):362-74.
12. Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, et al. Enhancement of wound healing by curcumin in animals. Wound Repair and Regeneration. 1998; 6(2):167-77.
13. Shamim A, Nawaz H, Hanif MA, Jilani MI, Júnior UL. Tree Turmeric. Medicinal Plants of South Asia: Elsevier; 2020. p. 645-55.
14. Iriventi P, Gupta NV. Topical delivery of curcumin and caffeine mixture-loaded nanostructured lipid carriers for effective treatment of psoriasis. Pharmacognosy Magazine. 2020; 16(68):206.
15. Shinzato T, Sato R, Suzuki K, Tomioka S, Sogawa H, Shulga S, et al. Proposal of therapeutic curcumin derivatives for Alzheimer’s disease based on ab initio molecular simulations. Chemical Physics Letters. 2020; 738:136883.
16. Farooqui AA, Farooqui T. Therapeutic Potentials of Curcumin in Parkinson’s Disease. Curcumin for Neurological and Psychiatric Disorders: Elsevier; 2019. p. 333-44.
17. Thao TTT, Minh TTT, Le Quynh TT. Study the effect of Plectranthii amboinicii’s tea in treatment of acute bronchitis. 2019.
18. Chaudhary N, Ueno-Shuto K, Ono T, Ohira Y, Watanabe K, Nasu A, et al. Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells. Biological and pharmaceutical bulletin. 2019; 42(3):489.
19. Momtazi-Borojeni AA, Abdollahi E, Nikfar B, Chaichian S, Ekhlasi-Hundrieser M. Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy. Heart failure reviews. 2019; 24(3):399-409.
20. Najeeb S, Khan SMMBN, Moeen-Ud-Din H, Murad SS. Curcumin present in plants reduces both the oxidation and circulation of oxidized levels of LDL cholesterol. International Journal of Medical Science in Clinical Research and Review. 2020; 3(02):: 206-14.
21. Banez MJ, Geluz MI, Chandra A, Hamdan T, Biswas OS, Bryan NS, et al. A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, Curcumin, and dietary nitric oxide supplementation on human cardiovascular health. Nutrition Research. 2020.
22. Hussain Z, Thu HE, Amjad MW, Hussain F, Ahmed TA, Khan S. Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives. Materials science and engineering: C. 2017; 77:1316-26.
23. Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D. Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. International immunopharmacology. 2014; 20(2):322-30.
24. Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis. Clinical nutrition. 2015; 34(6):1101-8.
25. Kohli K, Ali J, Ansari M, Raheman Z. Curcumin: a natural antiinflammatory agent. Indian Journal of Pharmacology. 2005; 37(3):141.
26. Yadav VR, Suresh S, Devi K, Yadav S. Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model. Aaps Pharmscitech. 2009; 10(3):752.
27. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer research. 2003; 23(1/A):363-98.
28. Agrawal DK, Mishra PK. Curcumin and its analogues: potential anticancer agents. Medicinal research reviews. 2010; 30(5):818-60.
29. Kuttan R, Sudheeran P, Josph C. Turmeric and curcumin as topical agents in cancer therapy. Tumori Journal. 1987; 73(1):29-31.
30. López‐Lázaro M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Molecular nutrition and food research. 2008; 52(S1):S103-S27.
31. Mahran RI, Hagras MM, Sun D, Brenner DE. Bringing curcumin to the clinic in cancer prevention: a review of strategies to enhance bioavailability and efficacy. The AAPS journal. 2017; 19(1):54-81.
32. Mosley CA, Liotta DC, Snyder JP. Highly active anticancer curcumin analogues. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease: Springer; 2007. p. 77-103.
33. Tang H, Murphy CJ, Zhang B, Shen Y, Van Kirk EA, Murdoch WJ, et al. Curcumin polymers as anticancer conjugates. Biomaterials. 2010; 31(27):7139-49.
34. Vallianou NG, Evangelopoulos A, Schizas N, Kazazis C. Potential anticancer properties and mechanisms of action of curcumin. Anticancer research. 2015; 35(2):645-51.
35. Wong KE, Ngai SC, Chan K-G, Lee L-H, Goh B-H, Chuah L-H. Curcumin Nanoformulations for Colorectal Cancer: A Review. Frontiers in Pharmacology. 2019; 10(152).
36. Yang Q-Q, Farha AK, Kim G, Gul K, Gan R-Y, Corke H. Antimicrobial and anticancer applications and related mechanisms of curcumin-mediated photodynamic treatments. Trends in Food Science and Technology. 2020.
37. Stanić Z. Curcumin, a compound from natural sources, a true scientific challenge–a review. Plant foods for human nutrition. 2017; 72(1):1-12.
38. Farooqui T, Farooqui AA. Curcumin: Historical Background, Chemistry, Pharmacological Action, and Potential Therapeutic Value. Curcumin for Neurological and Psychiatric Disorders: Elsevier; 2019. p. 23-44.
39. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin. Journal of Medicinal Chemistry. 2017; 60(5):1620-37.
40. Wang Y-J, Pan M-H, Cheng A-L, Lin L-I, Ho Y-S, Hsieh C-Y, et al. Stability of curcumin in buffer solutions and characterization of its degradation products. Journal of pharmaceutical and biomedical analysis. 1997; 15(12):1867-76.
41. Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The essential medicinal chemistry of curcumin: miniperspective. Journal of medicinal chemistry. 2017; 60(5):1620-37.
42. Kumar B, Singh V, Shankar R, Kumar K, K Rawal R. Synthetic and medicinal prospective of structurally modified curcumins. Current topics in medicinal chemistry. 2017; 17(2):148-61.
43. Zheng Q-T, Yang Z-H, Yu L-Y, Ren Y-Y, Huang Q-X, Liu Q, et al. Synthesis and antioxidant activity of curcumin analogs. Journal of Asian natural products research. 2017; 19(5):489-503.
44. Lee BH, Choi HA, Kim M-R, Hong J. Changes in chemical stability and bioactivities of curcumin by ultraviolet radiation. Food Science and Biotechnology. 2013; 22(1):279-82.
45. Sundaryono A, Nourmamode A, Gardrat C, Grelier S, Bravic G, Chasseau D, et al. Studies on the photochemistry of 1, 7-diphenyl-1, 6-heptadiene-3, 5-dione, a non-phenolic curcuminoid model. Photochemical and Photobiological Sciences. 2003; 2(9):914-20.
46. Ak T, Gülçin İ. Antioxidant and radical scavenging properties of curcumin. Chemico-biological interactions. 2008; 174(1):27-37.
47. Ashrafizadeh M, Ahmadi Z, Mohamamdinejad R, Farkhondeh T, Samarghandian S. Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury. Current Molecular Medicine. 2020.
48. Unnikrishnan M, Rao M. Inhibition of nitrite induced oxidation of hemoglobin by curcuminoids. Die Pharmazie. 1995; 50(7):490-2.
49. Azami SH, Nazarian H, Abdollahifar MA, Eini F, Farsani MA, Novin MG. The antioxidant curcumin postpones ovarian aging in young and middle-aged mice. Reproduction, Fertility and Development. 2020; 32(3):292-303.
50. Zhai SS, Ruan D, Zhu YW, Li MC, Ye H, Wang WC, et al. Protective effect of curcumin on ochratoxin A–induced liver oxidative injury in duck is mediated by modulating lipid metabolism and the intestinal microbiota. Poultry Science. 2020; 99(2):1124-34.
51. Elshama SS. The Therapeutic and Protective Role of Curcumin in Drugs and Chemicals Intoxication.
52. Almatroodi SA, Alrumaihi F, Alsahli MA, Alhommrani MF, Khan A, Rahmani AH. Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo (a) Pyrene (BaP) in Rats. Molecules. 2020; 25(3):724.
53. López-Malo D, Villarón-Casares CA, Alarcón-Jiménez J, Miranda M, Díaz-Llopis M, Romero FJ, et al. Curcumin as a Therapeutic Option in Retinal Diseases. Antioxidants. 2020; 9(1):48.
54. Shakeri A, Panahi Y, Johnston TP, Sahebkar A. Biological properties of metal complexes of curcumin. Biofactors. 2019; 45(3):304-17.
55. Murugan P, Pari L. Antioxidant effect of tetrahydrocurcumin in streptozotocin–nicotinamide induced diabetic rats. Life Sciences. 2006; 79(18):1720-8.
56. Ran Z, Zhang Y, Wen X, Ma J. Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway. Molecular medicine reports. 2019; 19(2):1024-31.
57. Morales I, Cerda-Troncoso C, Andrade V, Maccioni RB. The Natural Product Curcumin as a Potential Coadjuvant in Alzheimer’s Treatment. Journal of Alzheimer's Disease. 2017; 60:451-60.
58. Öz A, Çelik Ö. Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure. Molecular membrane biology. 2016; 33(3-5):76-88.
59. Choudhury AK, Raja S, Mahapatra S, Nagabhushanam K, Majeed M. Synthesis and evaluation of the anti-oxidant capacity of curcumin glucuronides, the major curcumin metabolites. Antioxidants. 2015; 4(4):750-67.
60. Ruby AJ, Kuttan G, Babu KD, Rajasekharan K, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer letters. 1995; 94(1):79-83.
61. Sahu PK. Design, structure activity relationship, cytotoxicity and evaluation of antioxidant activity of curcumin derivatives/analogues. European journal of medicinal chemistry. 2016; 121:510-6.
62. Sökmen M, Khan MA. The antioxidant activity of some curcuminoids and chalcones. Inflammopharmacology. 2016; 24(2-3):81-6.
63. Fang X, Fang L, Gou S, Cheng L. Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin. Bioorganic and medicinal chemistry letters. 2013; 23(5):1297-301.
64. Călinescu M, Fiastru M, Bala D, Mihailciuc C, Negreanu-Pîrjol T, Jurcă B. Synthesis, characterization, electrochemical behavior and antioxidant activity of new copper(II) coordination compounds with curcumin derivatives. Journal of Saudi Chemical Society. 2019; 23(7):817-27.
65. John J, Devi RS, Balachandran S. A comparative study on the antioxidant properties of curcuminoids and its rubrocurcumin analogues. Bulletin of Pure and Applied Sciences-Chemistry. 2018; 37(1):121-5.
66. Belluti S, Orteca G, Semeghini V, Rigillo G, Parenti F, Ferrari E, et al. Potent anti-cancer properties of phthalimide-based curcumin derivatives on prostate tumor cells. International journal of molecular sciences. 2019; 20(1):28.