Author(s): Chandra S., Manwani K.

Email(s): sureshcology81@gmail.com

DOI: 10.52711/0974-360X.2021.01157   

Address: Chandra S.*, Manwani K.
Pranveer Singh Institute of Technology, Kanpur-Agra-Delhi National Highway- 2, Bhauti, Kanpur, Uttar Pradesh, 209305.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
M. tinctoria plant has many therapeutic uses in traditional Indian medicine. M. tinctoria has Antibacterial, Antifungal, Hepatoprotective, Antioxidant, Wound Healing, Dye Yielding and Larvicidal properties. The study is employ to the anti- ulcerogenic potential of M. tinctoria extract. The plant extraction was done with 50% ethanol and 50% water (hydro-alcoholic). OECD guidelines were used for acute- toxicity (14 days) and Sub-acute toxicity (28 days). The study was carried by ligation (pylorus) and drug-induced ulcer models in Wistar rats. The anti-ulcer activity of M. tinctoria was compared with the standard drugs to perceive the anti-ulcerogenic potential. The Pharmacognostic analysis was performed according to the Indian pharmacopoeia. A preliminary Phytochemical test of the aerial part of M.tinctoria was performed which showed the presence of carbohydrates, amino acid, glycosides, flavonoids, alkaloids in the hydro-alcoholic extract. Acute-oral toxicity (14 days) and Sub-acute oral toxicity (28 days) were performed and doesn’t show any effect on body weight as well as organ weight and was non-toxic. M. tinctoria extract (MTE) effectively prevents the gastric mucosa from the threat of ulcers caused by pylorus ligation and aspirin-induced ulcers. MTE demonstrated a substantial reduction in the ulcer index developed by all 2 experimental models comparable to the standard drug Omeprazole. Current evidence shows that aerial parts of MTE have substantial antiulcer action.


Cite this article:
Chandra S., Manwani K. Evaluation of Anti Ulcerogenic Potential of Plant Extract of Morinda tinctoria. Research Journal of Pharmacy and Technology. 2021; 14(12):6699-4. doi: 10.52711/0974-360X.2021.01157

Cite(Electronic):
Chandra S., Manwani K. Evaluation of Anti Ulcerogenic Potential of Plant Extract of Morinda tinctoria. Research Journal of Pharmacy and Technology. 2021; 14(12):6699-4. doi: 10.52711/0974-360X.2021.01157   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-87


REFERENCES:
1.    Baghel SS, Dangi S, Soni P, Singh P, Shivhare Y. Acute toxicity study of aqueous extract of Coccinia indica (roots). Asian Journal of Research in Pharmaceutical Science. 2011;1(1):23-5.
2.    Praveena A, Sanjayan KP. A bioinformatics approach reveals the insecticidal property of Morinda tinctoria Roxb. against the cotton bollworm Helicoverpa armigra. Research Journal of Pharmacy and Technology. 2016;9(11):1829-34.
3.    Mathivanan N, Surendiran G, Srinivasan K, Malarvizhi K. Morinda pubescens JE Smith (Morinda tinctoria Roxb.) fruit extract accelerates wound healing in rats. Journal of medicinal food. 2006 Dec 1;9(4):591-3.
4.    Sahoo AK, Narayanan N, Kumar NS, Rajan S, Mukherjee PK. Phytochemical and therapeutic potentials of Morinda tinctoria Roxb.(Indian mulberry). Oriental Pharmacy and Experimental Medicine. 2009;9(2):101-5.
5.    Bagavan A, Rahuman AA, Kamaraj C, Geetha K. Larvicidal activity of saponin from Achyranthes aspera against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Parasitology research. 2008 Jun 1;103(1):223-9.
6.    Sivaraman D, Muralidharan P. Evaluation of Anti-microbial and Anti-inflammatory activity of Morinda tinctoria Roxb. Asian Journal of Experimental Biological Sciences. 2010;1(1):8-13.
7.    Praveena A, Sanjayan KP. Pharmacognostic Studies on Root-bark and fruit of Morinda tinctoria Roxb. Research Journal of Pharmacognosy and Phytochemistry. 2018;10(3):211-5.
8.    Hemmalakshmi S, Annapurani S, Devi SG. Comparative phytochemical screening and total phenolic content of different extracts of Ficus racemosa, Morinda Tinctoria and Nerium Indicum fresh leaves. Research Journal of Pharmacy and Technology. 2016;9(12):2222-7.
9.    Praveena A, Ramkumar G, Sanjayan KP. Phytochemical Screening of the Extract of the Root-Bark of Morinda tinctoria (Rubiaceae) for Secondary Metabolites. Research Journal of Pharmacy and Technology. 2012;5(1):83-7.
10.    Ouidad A, Sara C, Samir D. Biological properties and Acute Toxicity Study of Copper oxide nanoparticles prepared by aqueous leaves extract of Portulaca oleracea (L). Asian Journal of Pharmaceutical Research. 2020;10(2):89-94.
11.    Shay H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 1945;5:43-5.
12.    Rao CV, Ojha SK, Radhakrishnan K, Govindarajan R, Rastogi S, Mehrotra S, Pushpangadan P. Antiulcer activity of Utleria salicifolia rhizome extract. Journal of Ethnopharmacology. 2004 Apr 1;91(2-3):243-9.
13.    Zakaria ZA, Hisam EA, Rofiee MS, Norhafizah M, Somchit MN, Teh LK, Salleh MZ. In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. Journal of ethnopharmacology. 2011 Sep 2;137(2):1047-54.
14.    Goel RK. Effect of vegetable banana powder on changes induced by ulcerogenic agents in dissolved substances of gastric juice. Indian J Gastroenterol. 1985;4:249-51.
15.    Swetha Y, Reddy AK. Phytochemical and Pharmacological Studies of Methanolic Extract of Gymnema sylvestre leaves: an Approach for in vivo Antiulcer Activity. Research Journal of Pharmacology and Pharmacodynamics. 2012;4(6):368-72.
16.    Mahurkar N, Sayeed Ul Hasan SM. Synergistic Antiulcer Effect of Melatonin and Esomeprazole Combination in Pylorus Ligation, Ethanol, Aspirin induced Peptic Ulcers. Asian Journal of Pharmaceutical Research. 2015;5(1):10-4.
17.    Halkai MA, Mahurkar N, Ahmed MD, Beknal AK, Hasan SM, Swathi M. Evaluation of Gastroprotective Effect of Aqueous Leaf Extract of Commicarpus chinensis in Pylorus Ligted Albino Rats. Research Journal of Pharmacology and Pharmacodynamics. 2012;4(5):307-10.
18.    Srivastava A, Mishra A, Rai AK. Synthesis, Characterization and Evaluation of Ulcerogenic potential for NSAIDs-Alendronate based prodrug. Research Journal of Pharmacy and Technology. 2020 May 30;13(5):2107-11.
19.    Nitin M, Reddy UM, Hasan SM. Pharmacodynamic influence of vitamin C and Esomeprazole on gastro protection in pylorus ligation and aspirin induced ulcers in rats. Research Journal of Pharmacology and Pharmacodynamics. 2012;4(3):176-80.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Divakar Kanakagiri, Hari Omprakash, Kishore Kumar M, Vishwanadham Y

DOI: 10.5958/0974-360X.2017.00084.1         Access: Open Access Read More

Author(s): Yasmin A, Vijaya Bharathi R, Radha R

DOI: 10.5958/0974-360X.2019.00429.3         Access: Open Access Read More

Author(s): Sri Vasavi Reddy A, J. Suresh, Hemant K.S. Yadav, Apurva Singh

DOI: Not Available         Access: Open Access Read More

Author(s): A. Rajendra Kumar, N. J. Muthukumar, A. Faridha

DOI: 10.5958/0974-360X.2019.00081.7         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Neha Rajput, Dinesh Sachan, Shikha Gangwar, Dipti Sachan

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Priya Singh, Yogesh Shivhare, A.K Singhai, Abhishek Sharma

DOI:         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Padmavathi D., Netravati Deshpande, Sarala A.

DOI: Not Available         Access: Open Access Read More

Author(s): Prativa Biswasroy, Sthitapragnya Panda, Debajyoti Das, Durga Madhab Kar, Goutam Ghosh

DOI: 10.5958/0974-360X.2020.00090.6         Access: Open Access Read More

Author(s): R. Kumar, M. I. Khan, M. Prasad, Badruddeen

DOI: 10.5958/0974-360X.2019.00432.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags