Author(s): Ganesh Shenoy, Smita Shenoy, Sathish Pai B, Nitesh Kumar, Arul Amuthan, Manjunath Shetty, Mohandas Rao, Bharath Rao K

Email(s): smita.shenoy@manipal.edu

DOI: 10.52711/0974-360X.2021.01149   

Address: Mr. Ganesh Shenoy1, Dr. Smita Shenoy*2, Dr. Sathish Pai B3, Dr. Nitesh Kumar4, Dr. Arul Amuthan1, Mr. Manjunath Shetty1, Dr. Mohandas Rao5, Bharath Rao K6
1Selection Grade Lecturer, Department of Pharmacology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
2Professor and Head, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
3Professor, Department of Dermatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
3Assistant Professor, Department of Pharmacology and Toxicology, NIPER, Hajipur.
1Assistant Professor, Department of Pharmacology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104.
1Senior Grade Lecturer, Department of Pharmacology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Edu

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Vetpalai thailam, a Siddha formulation is used topically as well as orally in the treatment of Psoriasis. Vetpalai thailam is prepared from the leaves of Wrightia tinctoria by insolation with coconut oil as the base. The adverse effect profile of VT has not been addressed and hence this study was taken up to assess the long term toxicity of VT in rats. A 90-day repeated dose toxicity study was performed by modifying the protocol described by OECD guideline 408 for testing chemicals. The study constituted of six groups consisting of six rats in each group. There was no mortality among the six study groups. No signs of toxicity and behavioural changes were observed. The histopathological examination of vital organs did not show any change in the architecture. Our study demonstrates that Vetpalai thailam does not cause any toxicity on long term use in rats.


Cite this article:
Ganesh Shenoy, Smita Shenoy, Sathish Pai B, Nitesh Kumar, Arul Amuthan, Manjunath Shetty, Mohandas Rao, Bharath Rao K. Long term toxicity study of a Siddha formulation Vetpalai thailam (VT) in Rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6653-8. doi: 10.52711/0974-360X.2021.01149

Cite(Electronic):
Ganesh Shenoy, Smita Shenoy, Sathish Pai B, Nitesh Kumar, Arul Amuthan, Manjunath Shetty, Mohandas Rao, Bharath Rao K. Long term toxicity study of a Siddha formulation Vetpalai thailam (VT) in Rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6653-8. doi: 10.52711/0974-360X.2021.01149   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-79


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