Author(s): Saras Kumar Jain, Rohit Singhal, Neetesh K. Jain

Email(s): rsinghal01@rediffmail.com

DOI: 10.52711/0974-360X.2021.01077   

Address: Saras Kumar Jain, Rohit Singhal*, Neetesh K. Jain
Faculty of Pharmacy, Oriental University, Indore, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Pyrazoline is dihydropyrazole having only one endocyclic double bond. Synthesis of pyrazoline derivatives from chalcones is an active arena of investigation due to established pharmacological result. In present study, chalcones were prepared by reacting of acetophenone with benzaldehyde. Then prepared chalcones react with isoniazid in the presence of glacial acetic acid results pyrazoline derivative. Physical parameters such as color, crystal structure, solubility, melting point, retardation factor (Rf) and % yield was evaluated. Confirmations of structures of all synthesized derivatives, were done by spectroscopic data of IR, 1HNMR and Mass spectroscopy. Also, all synthesized compounds were evaluated for antibacterial activity against B. subtilis, S. aureus, P.aeruginosa and E.coli, and antifungal activity was accomplished against C. albicans and A. niger at the different conc. and concluded that some compounds have excellent antimicrobial activity and most of the synthesized compounds exhibits moderate antimicrobial activity.


Cite this article:
Saras Kumar Jain, Rohit Singhal, Neetesh K. Jain. Synthesis, characterization and biological activity of pyrazoline derivatives. Research Journal of Pharmacy and Technology. 2021; 14(12):6223-7. doi: 10.52711/0974-360X.2021.01077

Cite(Electronic):
Saras Kumar Jain, Rohit Singhal, Neetesh K. Jain. Synthesis, characterization and biological activity of pyrazoline derivatives. Research Journal of Pharmacy and Technology. 2021; 14(12):6223-7. doi: 10.52711/0974-360X.2021.01077   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-7


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