Author(s): Dibya Sundar Panda, Sai Krushna Padhy, Nabil K. Alruwaili, Mohammed Gamal, Ranjan Kumar Giri, Saroja Kumar Patro

Email(s): ranjanrifampin@gmail.com

DOI: 10.52711/0974-360X.2021.01076   

Address: Dibya Sundar Panda1, Sai Krushna Padhy2, Nabil K. Alruwaili11, Mohammed Gamal1, Ranjan Kumar Giri3, Saroja Kumar Patro3
1College of Pharmacy, Jouf University, Kingdom of Saudi Arabia.
2Sidhartha Institute of Pharmacy, Hyderabad, Telengana, India.
3Institute of Pharmacy and Technology, Salipur, Cuttack – 754202, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Objectives: Herbs are in use as medicine worldwide from the time immemorial. Many drugs derived from plant, animal or minerals are in use as medicine till date. This is a study on leaf extract of Putranjiva roxburghii Wall. (Euphorbiaceae) involving pharmacognosy, phytochemistry, activity against microbes and oxidation to substantiate its use. The leaf extracts were collected by successive soxhlation using solvents like petroleum ether, chloroform, benzene, acetone & ethanol. Chemicals present in the crude leaf extracts and isolated constituents were analyzed for both quality and quantity followed by TLC, UV–Visible Spectrophotometric analysis, HPTLC, Phytochemical tests and TLC examination confirmed to contain flavonoids in acetone, chloroform, aqueous and ethanol extract. The activity of Petroleum-ether, chloroform, acetone, alcoholic and aqueous extracts against the microbes was assessed by cup plate method. Okada & Okada method was followed to evaluate the DPPH free radical for aging property. The reducing, total antioxidant and peroxide radical for aging action of the extracts were assessed. The study confirmed significant antimicrobial and antioxidant property of the Putranjiva roxburghii Wall leaves may be for the presence of constituents like flavonoids, saponins, Phytosterols, favoring its traditional usage as medicine.


Cite this article:
Dibya Sundar Panda, Sai Krushna Padhy, Nabil K. Alruwaili, Mohammed Gamal, Ranjan Kumar Giri, Saroja Kumar Patro. Phytochemical analysis and investigation of Antimicrobial and Antioxidant potential of the Leaf Extracts of Putranjiva ruxburghi. Research Journal of Pharmacy and Technology. 2021; 14(12):6216-2. doi: 10.52711/0974-360X.2021.01076

Cite(Electronic):
Dibya Sundar Panda, Sai Krushna Padhy, Nabil K. Alruwaili, Mohammed Gamal, Ranjan Kumar Giri, Saroja Kumar Patro. Phytochemical analysis and investigation of Antimicrobial and Antioxidant potential of the Leaf Extracts of Putranjiva ruxburghi. Research Journal of Pharmacy and Technology. 2021; 14(12):6216-2. doi: 10.52711/0974-360X.2021.01076   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-6


REFERENCES:
1.    Swarbrick J.  Boylan JC. Plants as drugs. Encylopedia of Pharmaceutical Technology, Volume 3, Marcel Dekker Inc, New York. 2002; 2nded: pp. 2214-2216.
2.    Varier PS.  Indian medicinal plants: A compendium of 500 species, Vol.2, Orient Longman, Madras. 1994; pp. 347.
3.    Chatterjee A. Prakarshi SC. The treatise on Indian medicinal plants. Publications and Informations Directorate, New Delhi. 1994; pp.32.
4.    Bose TK. Das P.  Maiti GG. Trees of world, Vol. I, Regional Plant Research Center, Bhubaneswar, 1998; pp.184.
5.    Dymock W. Warden CJH. Hooper D.  Pharmacographiaindica, A history of the principal drugs of vegetable origin, Vol-3, Low price publication, New Delhi, 1995; pp.271.
6.    A modern herbal, 1982, Report on mala prepared from Putranjiva.[cited April 2014]. Available from:http://www.botanical.com/site/column_poudhia/57_mala.html.
7.    Wagner H. Bladt S. Plant drug analysis, Springer International publication, Basil. 2004; 2nded: pp.305.
8.    Stahl E. Thin layer chromatography, Springer International publication, Basil. 2004; 2nded: pp.686-705.
9.    Harbone JB. Phytochemical methods, Springer International publication, London. 1998; 3rd ed: pp.74-83.
10.    Kothari A, Shrivasthava N.  Antimicrobial activity of Ecliptaalba. Indian Drugs. 2004; 42: 133-135.
11.    Indian Pharmacopoeia. Government of India (vol. II), Published by the Controller of Publications, Ministry of Health and Family Welfare, New Delhi, Appendix 9, 1996; pp.100-143.
12.    Okada Y, Okada M. Scavenging effect of soluble proteins in broad beans on free radicals and active oxygen species. Journal Agriculture and Food Chemistry. 1998; 46: 401-406.
13.    Yen GC, Duh PD. Scavenging effect of methanolic extracts of peanut hulls on free-radical and active-oxygen species. Journal Agriculture and Food Chemistry.1994; 42: 629-32.
14.    Ermi A, Lia F. Screening Phytochemical, Antioxidant Activity and Vitamin C Assay from Bungo perak-perak (Begonia versicolar Irmsch) leaves. Asian Journal of Pharmaceutical Research. 2020; 10(3): 183-187.
15.    R. Malathi, S. Ahamed John, A. Cholarajan. Antioxidant Activity of Extract from the Leaves of Tylophora asthmatica. Asian Journal of Research in Pharmaceutical Scince. 2012; 2(2): April-June: 80-82.
16.    Madhu Ch., Swapna J, Neelima K, Monic V. Shah. A Comparative Evaluation of the Antioxidant Activity of Some Medicinal Plants Popularly Used in India. Asian Journal of Research in Pharmaceutical Science. 2012; 2(3): July-Sept. 98-100.
17.    Amit Roy, Dayananda Bhoumik, Ram Kumar Sahu, Jaya Dwivedi. Phytochemical Screening and Antioxidant Activity of Sesbania grandiflora Leaves Extracts. Asian Journal of Research in Pharmaceutical Scince. 2014; 4(1): Jan.-Mar. 16-21.
18.    Upadhye M, Dhiman A, Annie SA. Antioxidant activity of aqueous extracts of Holostemmaannulare. International Journal of Pharmacology and Toxicology. 2009; 10: 127-131.
19.    Sharma A, Bharadwaj S, Mann AS, Jain A, Kharya M.D. Screening methods of antioxidant activity; an overview. Pharmacognosy Reviews. 2007; 1: 232-237.
20.    Sushela V, Gopala Krishnan VK, Hiranmai YR. Free radical scavenging potential of Artemisia nilagirica (Clarke) pamp. Leaves. Journal of Advance Pharmacology and Toxicology. 2009; 10: 113-118.
21.    Naidu N, Sudheer Kumar G, Sivakrishna K, Anjinaik K, Praveen Kumar L, Sneha G. Anti microbial and antioxidant evolution of aqueous extract of Terminalia chebula using disc diffusion, H2O2 scavenging methods. Asian Journal of Research in Pharmaceutical Science. 2017; 7(2): 112-114.
22.    Prabakaran M, V. Thennarasu, Panneerselvam A. Screening of Antioxidant, Antimutagenic, Antimicrobial Activities and Phytochemical Studies on Sphaeranthus amaranthoides (Burm). Asian Journal of Pharmaceutical Technology. 2011; 1(4): Oct. - Dec. 125-129.
23.    Patel D.S.,  Shah P. B. , Managoli N. B.. Evaluation of In-vitro Anti-oxidant and Free Radical Scavenging activities of Withania somnifera and Aloe vera. Asian Journal of Pharmaceutical Technology. 2012; 2(4): Oct. - Dec. 143-147.
24.    Nidhi Rao, Sandhya Mittal, Sudhanshu, Ekta Menghani. Assessment of Phytochemical Screening, Antioxidant and Antibacterial Potential of the Methanolic Extract of Ricinus communis l. Asian Journal of Pharmaceutical Technology. 2013; 3(1): 20-25.
25.    Jaiganesh K. P., Sreedharren B., Arunachalam G., Nirmala R., Nepolean R.. Pharmacognostical and Antimicrobial investigation of Jatropha curcas, Linn., Leaf. Asian Journal of Research in Pharmaceutical Sciences. 2013; 3(4): 195-199.
26.    Preeti Tiwari. Antimicrobial Activity of Ashwagandharishta Prepared by Traditional and Modern Methods. Asian Journal of Research in Pharmaceutical Sciences. 2014; 4(3): 115-117.
27.    Kalaiyarasu T, Karthi N, Sharmila GV, Manju V. In vitro assessment of antioxidant and antibacterial activity of green synthesized silver nanoparticles from Digitariaradicosa leaves. Asian Journal of Pharmaceutical and Clinical Resarch. 2006; 9: 1.
28.    Emasushan  M, John BS, Marandi  RR, Ignace K, George M. Phytochemical analysis and antimicrobial activity of Putranjivaroxburghii wall. World Journal of pharmacy and pharmaceutical scinces. 2016; 5: 1157-1166.
29.    Polterait O. Antioxidants and free-radical scavengers of natural origin. Current Organic Chemistry. 1997; 1: 415-440.
30.    Patra JK, Baek KH. Novel green synthesis of gold nanoparticles using Citrulluslanatus rind and investigation of proteasome inhibitory activity, antibacterial, and antioxidant potential. International Journal of Nanomedicine. 2015; 10: 7253.
31.    Das G, Patra JK, Debnath T, Ansari A, Shin HS. Investigation of antioxidant, antibacterial, antidiabetic, and cytotoxicity potential of silver nanoparticles synthesized using the outer peel extract of Ananascomosus (L.). Plos one. 2019; 14(8): e0220950.

Recomonded Articles:

Author(s): Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta

DOI: 10.5958/0974-360X.2017.00425.5         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Ankit Patel, Pankaj Kushwah, Sujit Pillai, Ajay Raghuvanshi, Nitin Deshmukh

DOI: 10.5958/0974-360X.2017.00013.0         Access: Open Access Read More

Author(s): Trilokchandran. B, Vijayakumar G, Thippareddy K S

DOI: 10.5958/0974-360X.2019.00612.7         Access: Open Access Read More

Author(s): Sandeep DS, Narayana Charyulu R, Prashant Nayak, Aliss Maharjan, Indira Ghalan

DOI: 10.5958/0974-360X.2016.00163.3         Access: Open Access Read More

Author(s): Gopinath G, Thirumal M, P. R. Kumar

DOI: 10.5958/0974-360X.2020.00362.5         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Manoj S. Pagare, Leena Patil, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): Fathima Mariyam Niyas

DOI: 10.5958/0974-360X.2015.00182.1         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Niha Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): A.A. Yaroshenko, V.V. Parchenko, O.A. Bihdan, O.I. Panasenko, Yu V. Karpenko, E.O. Karpun

DOI: 10.52711/0974-360X.2021.00787         Access: Closed Access Read More

Author(s): Raad A. AL-Harmoosh, Nihad H. Mutlaq, Maytham M. Alabassi, Anmar M. AL-Shamari, Hussein M. AL-khafaji

DOI: 10.5958/0974-360X.2017.00618.7         Access: Open Access Read More

Author(s): Yasmin A, Vijaya Bharathi R, Radha R

DOI: 10.5958/0974-360X.2019.00429.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags