Author(s): Pooja Agarwal, Beena Kumari, Sangeeta, Manish Kumar

Email(s): manish_singh17@rediffmail.com

DOI: 10.52711/0974-360X.2021.01119   

Address: Pooja Agarwal1, Beena Kumari2, Sangeeta2, Manish Kumar3*
1Department of Pharmaceutical Science, Shivdan Singh Institute of Technology and Management, Aligarh, Uttar Pradesh.
2Department of Pharmaceutical Science, Indira Gandhi University, Meerpur, Rewari, Haryana, India-123401.
3M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
The combination of Domperidone and Lansoprazole is very useful in Gastro-esophageal disinfection (Dyspepsia). These methods provide means to separate the components characterize and quantify the components. An accurate, precise, specific and simple HPLC method was developed for simultaneous estimation of Domperidone and Lansoprazole. By this method retention time, linearity and accuracy data is respectively found for Domperidone and Lansoprazole. Mobile phase was prepared by mixing 51 volume of Acetonitrile and 49 volume of Ammonium Acetate (51:49 V/V) then 25mg each of Domperidone and Lansoprazole was dissolved in small volume of Acetonitrile: Ammonium Acetate (51:49 V/V) separately. Retention time was recorded 4.330 ± 0.003 minute and 5.820 ± 0.003 minute for Domperidone and Lansoprazole with 1.0 ml/min flow rate. The low value of % R.S.D indicates that this method is precise and accurate. Thus it can be concluded that the proposed method was good approach for obtaining reliable result.


Cite this article:
Pooja Agarwal, Beena Kumari, Sangeeta, Manish Kumar. Development of High Performance Liquid Chromatographic Estimation of Domperidone and Lansoprazole. Research Journal of Pharmacy and Technology. 2021; 14(12):6475-8. doi: 10.52711/0974-360X.2021.01119

Cite(Electronic):
Pooja Agarwal, Beena Kumari, Sangeeta, Manish Kumar. Development of High Performance Liquid Chromatographic Estimation of Domperidone and Lansoprazole. Research Journal of Pharmacy and Technology. 2021; 14(12):6475-8. doi: 10.52711/0974-360X.2021.01119   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-49


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