Author(s): Shruti Mittal, Prashant Gupta, Vijay Nigam

Email(s): shrutimittal2912@gmail.com

DOI: 10.52711/0974-360X.2021.01113   

Address: Shruti Mittal1*, Prashant Gupta1, Vijay Nigam2
1Department of Pharmacology, Daksh Institute of Pharmaceutical Science, Chhatarpur, India.
2Department of Pharmacognosy, Daksh Institute of Pharmaceutical Science, Chhatarpur, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. Ayurvedic medicine may be a powerful weapon given by our nature to cure disease. Considering the importance of plants as sources of drugs even today people are adopting different herbal drugs for the treatment of assorted diseases. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. This study planned to assess antidepressant like activity of methanolic extract of Clitoria ternatea Linn. (fabaceae). Soxhlet extraction method was used for methanolic extraction. Antidepressant activity was studied using forced swimming test (FST) and tail suspension test (TST). Two doses 200 and 400 mg/kg of methanolic extract of flower were selected for testing. Imipramine (10 mg/kg, i.p.) were used as the reference standard drugs. Methanolic extract of Clitoria ternatea flower significantly reduced immobility time in both TST and FST. Extract increased the climbing behavior in FST, which is similar to effect observed with imipramine. The results of this study suggest that antidepressant like effect of Clitoria ternatea seems to be mediated by an increase in norepinephrine level in synapses. However further study is needed to understand mechanism of action and to isolate the active component responsible for antidepressant like activity.


Cite this article:
Shruti Mittal, Prashant Gupta, Vijay Nigam. Evaluation of Antidepressant-like Effect of Clitoria ternatea Linn. Research Journal of Pharmacy and Technology. 2021; 14(12):6437-1. doi: 10.52711/0974-360X.2021.01113

Cite(Electronic):
Shruti Mittal, Prashant Gupta, Vijay Nigam. Evaluation of Antidepressant-like Effect of Clitoria ternatea Linn. Research Journal of Pharmacy and Technology. 2021; 14(12):6437-1. doi: 10.52711/0974-360X.2021.01113   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-43


REFERENCE:
1.    Fateme Ghaedi Heidari, Saeid Pahlavanzadeh, Mortaza Sabet Ghadam, Mahlagha Dehghan, RoohollahIder, “ The relationship between religiosity and depression among medical students” Asian J. Nur. Edu. And Research, 2016;6(3);414-418.
2.    Sangroyangla, Temjentula, Temjenyangla Imchen, Tsungrosenla, Vizayieno, Khumjanbeni Murry, “Prevalence of depression and the associate risk factors among the Elderly” Asian J. Nur. Edu. And Research, 2019;9(4);552-554.
3.    Indu Sharma, Mandeep Kaur, Bharat Parashar, Amrita Kainth, “Depression: An Overview” Asian J. Research Pharm Sci, 2014; 28-31.
4.    AvaniShewale, N. S. Naikwade, P. L. Ladda, “Antidepressant activity of Chrysanthemum morifolium Linn in mice” Asian J. Research Pharm Sci, 2019; 9(4): 260-266.
5.    Bahubali. J.G, Sanjay. T, Mahantesh. N, Sudhen Sumesh Kumar “Efficacy of Transcranial Magnetic Stimulation [TMS] among Major Depressive Disorder Patients: A Review”; Asian J. Nur. Edu. And Research, 2016; Vol.6; 1-6.
6.    Pavithra H Dave, V Vishnupriya, R. Gayathri, “Herbal Remedies for Anxiety and Depression- A Review” Research J. Pharm. And Tech, 2016; 9(8): 1253-1256.
7.    Sumanpreet Kaur “A Descriptive Study to Assess Depression among Elderly Population of selected Urban community of Cheharta Amritsar Punjab” Asian J. Nur. Edu. And Research, 2016; 6(3): 337-341.
8.    Pal Kuntal, KunduSampat Kumar, BhattacharjeeShatabisha, Roy Shounak. “A Review Paper on Psychiatry Disorders andits Treatment by Ayurvedic Approach”.PharmaTutor; 2014; 2(9); 30-35.
9.    Jaseela KP, Anjan Kumar, VeereshBabu. D, NarayanaSwamv V. B. “Studies on Anti- depressant and Anti-inflammatory Activities of curcuma aromatic Rhizome in Experimental Animals Models” Asian J. Pharm Sci, 2016; 6(2): 79-86.
10.    Praveen Kumar Uppala, Swarnalata M, Shashidhar Reddy R, G Chakravarthi, “Evaluation of anti-depressant activity of Methanolic Seed of Avena Sativa l. in mice”, Research J. Pharmacology and Pharmacodynamics. 2013; 5(4); 212-217.
11.    Peiyanga Rangasamy, Vadakkenchery Salimudheen Hansiya, Palanisamy Uma Mahaeshwari, Thamburaj Suman, Natesan Geetha “Phytochemical Analysis and Evaluaion of in vitro Antioxidant and Anti-urolithiatic Potential of Various Fraction of Clitoria ternatea L Blue Flowered Leaves” Asian J. Pharm. Ana. 2019; 9(2): 67-76.
12.    Mukherjee PK, Kumar V, Kumar NS, Heinrich M “The Ayurvedic medicine Clitoria ternatea—from traditional use to scientific assessment. J Ethnopharmacol. 2008, 120: 291-301.
13.    Manjula P., Mohan CH., Sreekant D., Keerthi B., Pratibhadevi B. “Phytochemical Analysis of Clitoriaternatea LINN., a valuable medicinal plant”. J. Indian bot. Soc; 2013; Vol. 92 (3 and 4); 173-178.
14.    Asolkar LV, Kakkar KK, Chakre OJ. “Second Suppliment to Glossary of Indian Medicinal Plants with Active Principle” Part-1 (A-K), 2005, 2nd edition. NISCAIR Press, Part-1 (A-K), 2005, 217.
15.    Vogel H. Gehard “Drug Discovery and Evaluation” Pharmacological Assay; Second edition; 2011.546-561.
16.    VCastagné, P Moser,  S Roux, RDPorsolt.“Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice” National Center for biotechnology Information; 2011;Chapter 8:Unit 8;10A.
17.    Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V, Kaempferol from the leaves Apocynumvenetum possesses anxiolytic activities in the elevated plus maze test in mice, Phytomedicine, 2009, 16, 295- 302.
18.    Kumar D, Kumar S, Evaluation of antianxiety activity of Calotropisgigantea roots, Journal of Fundamental Pharmaceutical Research, 2, 2014, 30-37.
19.    Wadood A, Ghufran M, Jamal SB, Naeem M, Khan A, Ghaffar R. Phytochemical analysis of medicinal plants occurring in local area of Mardan. Biochem Anal Biochem. 2013;2(4):1–4.
20.    Butterweck V, Jürgenliemk G, Nahrstedt A, Winterhoff H. Flavonoids from hypericumperforatum show antidepressant activity in the forced swimming test. Planta Med. 2000;66(21):3–6.
21.    Prakash O, Kumar D, Kumar S, Screening of methanol extract and ethyl acetate fraction of AbieswebbianaLindl. for neuropharmacological activities, Indian Journal of Research in Pharmacy and Biotechnology Deepak and Mahaveer ISSN: 2321-5674(Print); 2320 – 3471(Online) IJRPB 4(3) www.ijrpb.com May-June 2016 Page 94 Indian Journal of Pharmaceutical Sciences, 77, 2015, 536-541.
22.    Bergendorff O, Dekermendjian K, Nielsen M, Shan R, Witt R, Ai J, Sterner O, Furanocoumarins with affinity to brain benzodiazepine receptors in vitro, Phytochemistry, 44, 1997, 1121-1124.
23.    Yanpallewar S, Rai S, Kumar M, Chauhan S, Acharya SB, Neuroprotective effect of Azadirachtaindica on cerebral post-ischemic reperfusion and hypoperfusion in rats, Life Sciences, 76, 2005, 1325- 1338.
24.    Une HD, Sarveiya VP, Pal SC, Kasture VS, Kasture SB, Nootropic and anxiolytic activity of saponins of Albizzialebbeck leaves, Pharmacology Biochemistry and Behavior, 69, 2001, 439-444.

Recomonded Articles:

Author(s): P.Maheshwari, D.Pavithra, Neethu.T.T, T.S. Shanmugarajan, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00011.7         Access: Open Access Read More

Author(s): Uday Gaikwad, Milind Parle

DOI: Not Available         Access: Open Access Read More

Author(s): R. S. Adnaik, P. S. Gavarkar, S. K. Mohite, C, S Magdum

DOI: Not Available         Access: Open Access Read More

Author(s): Dheeraj Ahirwar, Bharti Ahirwar

DOI: 10.5958/0974-360X.2020.00291.7         Access: Open Access Read More

Author(s): Jong-Im Kim, Sun Kyung Kim, Hyunjoo Kim, Sunae Kim, Taehui Kim, Keumok Park, Bohyun Kim

DOI: 10.5958/0974-360X.2017.00544.3         Access: Open Access Read More

Author(s): K. C Panda , A. V Reddy, N. Panda, MD Shamim, M. Habibuddin, K.N Jayaveera

DOI: 10.5958/0974-360X.2018.00050.1         Access: Open Access Read More

Author(s): Jiji K N, P. Muralidharan

DOI: 10.5958/0974-360X.2020.00960.9         Access: Open Access Read More

Author(s): Srishti Chaudhary, Pankaj Kumar Prashar, Anamika Gautam, Ankita Sood, Sachin Kumar Singh, Monica Gulati, Narendra Kumar Pandey, Bimlesh Kumar

DOI: 10.52711/0974-360X.2021.00507         Access: Closed Access Read More

Author(s): Keziya Ann Mammenand, S. Sathesh Kumar

DOI: 10.5958/0974-360X.2017.00459.0         Access: Open Access Read More

Author(s): Young-Chul Lee, Sang-Sub Park

DOI: 10.5958/0974-360X.2017.00418.8         Access: Open Access Read More

Author(s): Moon R. S., Mitkare S.S., Kshirsagar R.V, Kale A.G., Shinde N.D., Malewar A.S., Pawde P.K.

DOI:         Access: Open Access Read More

Author(s): Rifa’atul Mahmudah, I Ketut Adnyana, Elin Yulinah Sukandar

DOI: 10.5958/0974-360X.2020.00955.5         Access: Open Access Read More

Author(s): Ganesan V , Lokesh Mangalmurti Chitrivekar

DOI: Not Available         Access: Open Access Read More

Author(s): Tarani Prakash Shrivastava, Umesh Kumar Patil, Satyendra Garg, Meghna A. Singh

DOI: Not Available         Access: Open Access Read More

Author(s): Satyabrata bhanja, K. Lakshmi Deepthi, Muvvala Sudhakar, Bibhuti Bhusan Panigrahi

DOI: Not Available         Access: Open Access Read More

Author(s): Pavithra H Dave, V. Vishnupriya, R. Gayathri

DOI: 10.5958/0974-360X.2016.00237.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags