Shubhika Jain, Bharti Chogtu, Vybhava Krishna, Isha Khadke
Shubhika Jain1*, Bharti Chogtu2, Vybhava Krishna3, Isha Khadke3
1MBBS Undergraduate, Kasturba Medical College, Manipal Academy of Higher Education - 576104, India.
2Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 576104.
3Post Graduate Student, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 576104.
Volume - 14,
Issue - 12,
Year - 2021
Serotonin causes a significant shift in the excitability of neurons and endogenous serotonin and drugs acting on serotonergic receptors play a role in pathogenesis of epilepsy. This study was done to study the effect of Mosapride, a serotonin receptor 5HT4 agonist, in animal models of epilepsy. Albino Wistar rats were divided into 5 groups with six animals in each group. Group 1 was control group, group 2 was standard group and group 3, 4 and 5 received test drug mosapride in low dose (3mg/kg), high dose (6mg/kg) and mosapride plus standard antiepileptic drug respectively. The antiepileptic efficacy was evaluated using Maximal Electroshock Seizure model (MES) and Pentylenetetrazole (PTZ) induced convulsions. Data was analysed using ANOVA followed by post hoc Tukeys test. Mosapride treated animals showed statistically significant decrease (p<0.001) in the duration of flexion, hind limb extension and post ictal depression in MES model which was comparable to phenytoin group. In PTZ model, mosapride alone did not show any significant difference as compared to control group in terms of latency and duration of seizures (p>0.05). The antiepileptic efficacy of mosapride is similar to phenytoin in MES model. However, in PTZ model mosapride did not show any beneficial antiepileptic effect.
Cite this article:
Shubhika Jain, Bharti Chogtu, Vybhava Krishna, Isha Khadke. Evaluation of Antiepileptic activity of Mosapride in Albino wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6364-8. doi: 10.52711/0974-360X.2021.01100
Shubhika Jain, Bharti Chogtu, Vybhava Krishna, Isha Khadke. Evaluation of Antiepileptic activity of Mosapride in Albino wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6364-8. doi: 10.52711/0974-360X.2021.01100 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-30
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