Author(s): Shubhika Jain, Bharti Chogtu, Vybhava Krishna, Isha Khadke


DOI: 10.52711/0974-360X.2021.01100   

Address: Shubhika Jain1*, Bharti Chogtu2, Vybhava Krishna3, Isha Khadke3
1MBBS Undergraduate, Kasturba Medical College, Manipal Academy of Higher Education - 576104, India.
2Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 576104.
3Post Graduate Student, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. 576104.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021

Serotonin causes a significant shift in the excitability of neurons and endogenous serotonin and drugs acting on serotonergic receptors play a role in pathogenesis of epilepsy. This study was done to study the effect of Mosapride, a serotonin receptor 5HT4 agonist, in animal models of epilepsy. Albino Wistar rats were divided into 5 groups with six animals in each group. Group 1 was control group, group 2 was standard group and group 3, 4 and 5 received test drug mosapride in low dose (3mg/kg), high dose (6mg/kg) and mosapride plus standard antiepileptic drug respectively. The antiepileptic efficacy was evaluated using Maximal Electroshock Seizure model (MES) and Pentylenetetrazole (PTZ) induced convulsions. Data was analysed using ANOVA followed by post hoc Tukeys test. Mosapride treated animals showed statistically significant decrease (p<0.001) in the duration of flexion, hind limb extension and post ictal depression in MES model which was comparable to phenytoin group. In PTZ model, mosapride alone did not show any significant difference as compared to control group in terms of latency and duration of seizures (p>0.05). The antiepileptic efficacy of mosapride is similar to phenytoin in MES model. However, in PTZ model mosapride did not show any beneficial antiepileptic effect.

Cite this article:
Shubhika Jain, Bharti Chogtu, Vybhava Krishna, Isha Khadke. Evaluation of Antiepileptic activity of Mosapride in Albino wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6364-8. doi: 10.52711/0974-360X.2021.01100

Shubhika Jain, Bharti Chogtu, Vybhava Krishna, Isha Khadke. Evaluation of Antiepileptic activity of Mosapride in Albino wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6364-8. doi: 10.52711/0974-360X.2021.01100   Available on:

1.     Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014; 55:475-82.
2.     Amudhan S, Gururaj G, Satishchandra P. Epilepsy in India I: Epidemiology and public health. Ann Indian Acad Neurol. 2015; 18(3):263-773.
3.     Dinta Suresh, Meena Aggarwal, Achal Srivastava, Mamta Bhushan Singh. A Comparative Study to Assess the Knowledge of Caregivers of People with Epilepsy and General Public Regarding Epilepsy and its First- Aid Management. Asian J. Nur. Edu. and Research.2017; 7(2): 147-150.
4.     Keziya Ann Mammenand, S. Sathesh Kumar. A Prospective Observational Study on Depression in Epileptic Patients. Research J. Pharm. and Tech. 2017; 10(8): 2587-2590.
5.     E. Komali, Ch. Venkataramaiah, W. Rajendra. Anticonvulsant effect of Bacopa monnieri extracts on Catecholamine metabolism during PTZ - induced Epilepsy in different brain regions of Albino Rat. Research J. Pharm. and Tech 2018; 11(4): 1592-1598.
6.      Kwan P, Schachter SC, Brodie MJ. Drug-resistant epilepsy. N Engl J Med. 2011; 8;365:919-26.
7.     Reena Singh, Suvendu Narayan Mishra, Monalisa Jena. A Comparative study to indentify the Psychosocial adjustment of Patients with Epilepsy and Schizophrenia in a Tertiary Care Teaching Hospital. Research J. Pharm. and Tech. 7(8): August 2014 Page 870-875.
8.     Pisani F, Spina E, Oteri G. Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice. Epilepsia. 1999;40 Suppl 10:S48-56.
9.     Jobe PC. Common pathogenic mechanisms between depression and epilepsy: an experimental perspective. Epilepsy and Behav. 2003;4: S14-24.
10. Raju SS, Noor AR, Gurthu S, Giriyappanavar CR, Acharya SB, Low HC, et al. Effect of fluoxetine on maximal electroshock seizures in mice: acute vs chronic administration. Pharmacol Res. 1999; 39:451-4.
11.     Bagdy G, Kecskemeti V, Riba P, Jakus R. Serotonin and epilepsy. J Neurochem.2007 ;100: 857-73.
12.     Lucas G, Debonnel G. 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity. Eur J Neurosci. 2002;16:817-22.
13.     Bourson A, Kapps V, Zwingelstein C, Rudler A, Boess FG, Sleight AJ. Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice. Naunyn Schmiedebergs Arch Pharmacol. 1997;356: 820-6
14.     Srinivasa Rao Narala, K. Saraswathi. Adaptation of Color Reactions for Spectrophotometric Determination of Mosapride Citrate in Formulations. Asian J. Research Chem. 4(6): June, 2011; Page 896-897.
15.     Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016 Mar; 7: 27-31.
16.     Coppola G, Arcieri S, D'Aniello A, Messana T, Verrotti A, Signoriello G, Pascotto A. Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. Seizure. 2010 Jun;19(5):296-9
17.     Srivastava AK, Gupta SK, Jain S, Gupta YK. Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in rats. Methods Find Exp Clin Pharmacol. 2002 Apr;24:145-913.
18.     Gardier AM, Wurtman RJ. Persistent blockade of potassium-evoked serotonin release from rat frontocortical terminals after fluoxetine administration. Brain Res. 1991 Feb 1;540(1-2):325-30.
19.     Reeta Kh, Prabhakar P, Gupta YK. Anticonvulsant activity of the antidepressant drug, tianeptine, against pentylenetetrazole-induced seizures mitigates cognitive impairment in rats. Behav Pharmacol. 2016; 27: 623-32.
20.     Pratik Swarup Das, Puja Saha . Development and Optimization of Orodispersible Tablets of Serotonin Hydrochloride. Res. J. Pharma. Dosage Forms and Tech.2018; 10(1): 13-16.
21.     Ahmed Chyad Abbas, Wijdan Rajh Hamza Al-Kraity, Ebtihal Chiad Abbas. Effect Antioxidant and Serotonin Level in the Sera on Type II Diabetes Mellitus Males Patients and Compare with Control Group. Research J. Pharm. and Tech. 2019; 12(5):2453-2460
22.     Meshkibaf MH, Subhash MN, Lakshmana KM, Rao BS. Effect of chronic administration of phenytoin on regional monoamine levels in rat brain. Neurochem Res. 1995; 20(7):773-8.
23.     Kale Rupali C, Gadgil Swati S, Borole Kanchan D, Wele Asmita A. Experimental Evaluation of Antiepileptic Activity of Amalakyadi Ghrita. Research Journal of Pharmacology and Pharmacodynamics. 2015; 7(4): 155-160.
24. Murugesan A, Rani MRS, Hampson J, Zonjy B, Lacuey N, Faingold CL et al. Serum serotonin levels in patients with epileptic seizures. Epilepsia. 2018;59 (6):e91-e97
25. Buchanan GF, Murray NM, Hajek MA, Richerson GB. Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. J Physiol. 2014 ;592(19):4395-410..
26. Ahmad S, Fowler LJ, Whitton PS. Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids. Epilepsy Res. 2005; 63(2-3):141-9
27. Maia GH, Brazete CS, Soares JI, Luz LL, Lukoyanov NV. Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy. Brain Res Bull. 2017;134: 109-120.
28. Watanabe K, Minabe Y, Ashby CR Jr, Katsumori H. Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats. Eur J Pharmacol. 1998 5;350(2-3):181-8.
29.    Castro-Alamancos  MA. Neocortical synchronized oscillations induced by thalamic disinhibition in vivo. J Neurosci. 1999; 19:RC27
30.     Bertram EH, Zhang DX. Thalamic excitation of hippocampal CA1 neurons: a comparison with the effects of CA3 stimulation. Neuroscience. 1999; 92 :15-26.
31.     Bercovici E, Cortez MA, Wang X, Snead OC 3rd. Serotonin depletion attenuates AY-9944-mediated atypical absence seizures. Epilepsia. 2006; 47(2):240-6.
32.     Ohno Y, Sofue N, Imaoku T, Morishita E, Kumafuji K, Sasa M et al. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. J Pharmacol Sci. 2010;114: 99-105.
33.     Compan V, Zhou M, Grailhe R, Gazzara RA, Martin R, Gingrich J et al. Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci. 2004; 24 (2): 412-9

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