Author(s): Abhinav Mishra, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad

Email(s): abmishrasip20@gmail.com

DOI: 10.52711/0974-360X.2021.01099   

Address: Abhinav Mishra*, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad
Shambhunath Insitute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
In the present investigation the glucose lowering potential of the leaf extracts of Crinum asiaticum were prepared using cold maceration technique in solvents of varying polarity. The extracts exhibited the presence of flavonoids, alkaloids, phenolics and tannins. The oral toxicity of the aqueous and ethanolic extracts was determined and these two extracts were used of evaluating the antidiabetic activity. Oral glucose tolerance test was performed and diabetes was induced using alloxan (150 mg/kg) in rats. Ethanolic and aqueous extracts at two dose levels (200 mg/kg and 400mg/kg) were used for evaluating glucose lowering capability. Both the aqueous and the ethanolic extracts were found to significantly reduce glucose levels with the aqueous extract at dose level 200 mg/kg being the most effective (50% reduction) whereas the ethanolic extract was able to reduce the blood glucose by around 35% at the same dose level.


Cite this article:
Abhinav Mishra, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad. Ameliorative potential of Crinum asiaticum Linn leaf extracts on Elevated blood glucose in Alloxan-induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6359-3. doi: 10.52711/0974-360X.2021.01099

Cite(Electronic):
Abhinav Mishra, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad. Ameliorative potential of Crinum asiaticum Linn leaf extracts on Elevated blood glucose in Alloxan-induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6359-3. doi: 10.52711/0974-360X.2021.01099   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-29


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