K Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma
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K Poojita1, Fajeelath Fathima1, Rajdeep Ray1, Lalit Kumar2, Ruchi Verma1*
1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar - 576104, Manipal, Udupi, Karnataka, India.
2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar - 576104, Manipal, Udupi, Karnataka, India.
Volume - 14,
Issue - 12,
Year - 2021
Tuberculosis is one of the leading cause of increase in mortality rate in today’s health care scenario. Due to increase frequency of drug resistant TB it is prudent to find new targets and promising targets for anti-tubercular activity. MmpL3 (Mycobacterial Membrane Protein Large 3) is one of the most effective and promiscuous targets for development of new drug for anti-tubercular therapy due to its cross resistance inhibition property. In this study we have presented atom based 3D QSAR and finger print based 2D QSAR models to study different structural and functional groups of Adamantyl urea derivatives and their action in MmpL3 inhibitory activity which will provide us the insight for designing better and far more effective anti TB drugs.
Cite this article:
K Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma. Atom based 3D QSAR and Fingerprint based 2D QSAR of Novel Molecules as MmpL3 receptor inhibitors for Mycobacterium tuberculosis. Research Journal of Pharmacy and Technology. 2021; 14(12):6321-9. doi: 10.52711/0974-360X.2021.01093
K Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma. Atom based 3D QSAR and Fingerprint based 2D QSAR of Novel Molecules as MmpL3 receptor inhibitors for Mycobacterium tuberculosis. Research Journal of Pharmacy and Technology. 2021; 14(12):6321-9. doi: 10.52711/0974-360X.2021.01093 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-23
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