Author(s): Prashant Kumar Gupta, Chandradeo Narayan, Kamal Shah, Arvind Kumar, Brij Mohan Singh

Email(s): prashantgupta27@gmail.com , shahkamal.123@gmail.com , k_arvindk@rediffmail.com , hodkb2006@yahoo.co.on

DOI: 10.52711/0974-360X.2021.01091   

Address: Prashant Kumar Gupta1*, Chandradeo Narayan2, Kamal Shah3, Arvind Kumar4, Brij Mohan Singh5
1Shri NPA Govt Ayurveda College, Raipur, Chhattisgarh India.
2Post graduate Institute of Medical Science, Chandigarh, India.
3Institute of Pharmaceutical Research, GLA University, Mathura, India.
4School of Biotechnology, Banaras Hindu University, Varanasi, India.
5Faculty of Ayurveda, Banaras Hindu University, Varanasi, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Human being knows honey since thousands of years for its nutritional and medicinal values. Traditional medicine systems like Ayurveda have elaborated honey as boon for health and patient care. Synergistic effect of honey was research but to a limited extend. Honey is advised with Picrorhiza kurroa for hepatic disorders or hepato-protection in Ayurveda. Here we have examined in vitro synergistic effect of honey when given with Picrorhiza kurroa in acetaminophen-induced hepatotoxicity in Balb/c mice model. We obtained Serum and liver lysate to check levels of hepatic markers, Alkaline phosphatase and Glutathione. The level of alkaline phosphatase raised while glutathione level is reduced during hepatic offence. We observed a compensation of above markers when P. Kurrua, honey and its combination were used in acetaminophen induced hepatic toxicity. We observed a better mice weight gain in combination group (Group IV) compared to control group. This study can pave a way for future research on honey as a better adjuvant for hepatotoxic drugs and other herb-drug interactions researches.


Cite this article:
Prashant Kumar Gupta, Chandradeo Narayan, Kamal Shah, Arvind Kumar, Brij Mohan Singh. In vitro analysis of synergistic effect of honey against chemically induced hepatic insult in Balb/c mice. Research Journal of Pharmacy and Technology. 2021; 14(12):6309-4. doi: 10.52711/0974-360X.2021.01091

Cite(Electronic):
Prashant Kumar Gupta, Chandradeo Narayan, Kamal Shah, Arvind Kumar, Brij Mohan Singh. In vitro analysis of synergistic effect of honey against chemically induced hepatic insult in Balb/c mice. Research Journal of Pharmacy and Technology. 2021; 14(12):6309-4. doi: 10.52711/0974-360X.2021.01091   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-21


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