Author(s): Ajay Sharma, Gyanendra Kumar Sharma, Himansu Chopra

Email(s): Ajaysharma199740@gmail.com

DOI: 10.52711/0974-360X.2021.01090   

Address: Ajay Sharma*, Gyanendra Kumar Sharma, Himansu Chopra
Rajiv Academy for Pharmacy, Mathura-281001.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Pyrazoline is a 5-membered heterocyclic moiety has two adjoining nitrogen iotas and three carbon particles inside the ring. Pyrazoline subordinate are related wide scope of pharmacological and restorative exercises, for example, antibacterial, antifungal, pain relieving, calming, hostile to parasitic, against malarial, against oxidant. The ongoing work of exploration is fundamentally engaged at the revelation and improvement of a progression of 1,3,5-trisubstituted pyrazoline. A progression of new 1-phenyl-3-(4-nitrophenyl)- 5-(subbed phenyl) pyrazoline subordinates (2a-2j) were blended by the response of subbed acetophenone and subbed benzaldehyde within the sight of fluid sodium hydroxide arrangement by Claisen Schmidt buildup system. The subbed chalcone were integrated which is additionally dense with phenyl hydrazine in ethanol and results in the definition of conclusive subordinates of pyrazoline (2a-2j). The response blend was observed by TLC and the last mixes were refined by recrystallization from wanted dissolvable. All the structures of blended mixes were affirmed by FTIR, 1H NMR, mass unearthly information and essential investigation. All the recently combined mixes (2a-2j) were assessed for antibacterial and antifungal movement. Mixes 2f, 2i and 2h showed powerful inhibitory impact against on strains of both bacterial and parasitic species.


Cite this article:
Ajay Sharma, Gyanendra Kumar Sharma, Himansu Chopra. Synthesis and Biological evaluation of some newer Pyrazole Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(12):6304-8. doi: 10.52711/0974-360X.2021.01090

Cite(Electronic):
Ajay Sharma, Gyanendra Kumar Sharma, Himansu Chopra. Synthesis and Biological evaluation of some newer Pyrazole Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(12):6304-8. doi: 10.52711/0974-360X.2021.01090   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-20


REFERENCES:
1.    Ansari A, Ali A. and Asif M, Biologically active pyrazole derivatives. New Journal of Chemistry. 2017; 41(1): pp.16-41.  
2.    Kumar V, Kaur K, Gupta G.K. and Sharma A.K. Pyrazole containing natural products: synthetic preview and biological significance. European Journal of Medicinal Chemistry. 2013; 69: pp.735-753.
3.    SS Mokle, MA Sayyed, AY Vibhute, SV Khansole, YS Nalwar, YB Vibhute. Synthesis of Some New Bioactive Chalcones and Flavones. Research Journal of Pharmacy and Technology. 2009; 2 (4): pp. 846-849.
4.    Ramesh B, Azma Yasmeen, Shivakumar Swamy, Someswara Rao B. Synthesis and Anti-inflammatory Activity of Some New 2-Pyrazoline Derivatives. Research Journal of Pharmacy and Technology. 2010; 3(2):   pp. 625-626
5.    Bardalai D.B. Pyrazole and 2-pyrazoline derivatives: potential anti-inflammatory and analgesic agents. International Research Journal of Pharmaceutical and Applied Sciences. 2012; 2(3): pp.1
6.    Kavitha N.V, Divekar K, Priyadarshini B, Gajanan, S. and Manjunath M. Synthesis and antimicrobial activities of some new pyrazole derivatives. Der Pharma Chemica. 2011; 3(4): pp.55-62.
7.    Kumud Gupta, Surendra Nath Pandeya, Ashish Kumar Pathak, Anuradha Gupta, Synthesis and Antibacterial Activity of Ciprofloxacin Derivatives. Research Journal of Pharmacy and Technology. 2011; 4(2): 308-314
8.    Bhat I, and Jainey P.J. Antimicrobial studies of some substituted pyrazoline derivatives derived from acetyl hydrazines. Asian J Pharm Clin Res. 2014; 7(4): pp.237-239.
9.    Singh S, Sharma S, Jadon P.S. Synthesis and Biological Evaluation of Some New Chalcone Derivatives for their Antimicrobial Activities. Research Journal of Pharmacy and Technology. 2012; 5(2):  253-262.
10.    K.Girija, P. Seethalakshmi, K.Hemalatha, N. Arumugam. . Research Journal of Pharmacy and Technology. 2014; 7(4):  460-462.
11.    Bhatt I, Kumar A, Synthesis and Biological Evaluation of Some Novel Pyrazoline Derivatives Derived from Chalcones. Research Journal of Pharmacy and Technology. 2017; 10(5): 1344-1346.
12.    Singh I. Synthesis of newly substituted pyrazole derivative and their anti-inflammatory activity, European Journal of Pharmaceutical and Research. 2018: 452.
13.    Ashok D, Kavitha R, Gundu, S. and Hanumantha R.V.  Microwave-assisted synthesis of new pyrazole derivatives bearing 1, 2, 3-triazole scaffold as potential antimicrobial agents. Journal of the Serbian Chemical Society. 2017; 82(4): 357-366.
14.    Kumar A, Fernandes J, and Kumar P. Synthesis and biological evaluation of some novel pyrazoline incorporated 2-quinolones. Research Journal of Pharmacy and Technology. 2016; 9(12):  2257-2260.
15.    Divekar K, Swamy S, Murugan V. and Devgun M. Synthesis and evaluation of some new pyrazole derivatives as antimicrobial agents. Research Journal of Pharmacy and Technology. 2010; 3(4):  1039-1043.
16.    Bhat K.I. and Kumar A. Pyrazolines as potent antioxidant agents. Research Journal of Pharmacy and Technology. 2018; 11(5): 1978-1980.
17.    Singh K, Kumari S. and Gupta Y.K. Synthesis and Antimicrobial Activity of New Pyrazoles and Chalcones Derived from Cyclic Imides. Research Journal of Pharmacy and Technology. 2017; 10(12): 4479-4484.
18.    Revanasiddappa B.C, Kumar M.V, Nayak P, Ali A.R. and Jisha, M.S. Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives. Research Journal of Pharmacy and Technology. 2017; 10(5): 1481-1484.
19.    Faruk Alam. Synthesis and Biological Evaluation of Some Pyrazole-based Mannich Bases. Research Journal of Pharmacy and Technology. 2019; 12(9):  4225-4230.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available