Author(s): Sambit Dash, Pragna Rao, Ullas Kamath, Aparna R Pai, Prasanna Kumar Reddy Gayam, Ekta Rati, Shivani Karnik, Alex Joseph, Angel Treasa Alex

Email(s): angel.alex@manipal.edu

DOI: 10.52711/0974-360X.2021.01086   

Address: Sambit Dash1, Pragna Rao2, Ullas Kamath1, Aparna R Pai3, Prasanna Kumar Reddy Gayam4, Ekta Rati5, Shivani Karnik4, Alex Joseph5, Angel Treasa Alex4
1Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
2Manipal Academy of Higher Education (MAHE), Bangalore, India.
1Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
3Department of Neurology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
4Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.
5Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Gold nanoparticles have found a wide range of application in biomedical sciences. Unique properties of these metal nanoparticles include surface plasmon resonance and size dependent colour change. Various molecules have been functionalized on the gold nanoparticles surface but carbohydrates have garnered attention due to their properties and their role in living systems. However certain challenges make carbohydrate-gold nanoparticles association difficult to obtain and stabilize. This study was carried out to chemically remodel gold nanoparticles by adding a monosaccharide mannose to its surface. A modified phase transfer method was used to synthesize gold nanoparticles. The surface of the nanoparticles was fixed with cyanuric chloride to serve as a linker. Mannose was then linked to the linker molecule. All three stages of the process, gold nanoparticles, and gold nanoparticles with linker and gold nanoparticles with the carbohydrate were analyzed for size and stability. Zeta potential and UV-vis data exhibited stable gold nanoparticles dispersion, successful binding of linker molecule as well as the carbohydrate. This study shows a simple, cost-effective and robust method of glycomodification of gold nanoparticles surface which can further find use in wide ranging applications.


Cite this article:
Sambit Dash, Pragna Rao, Ullas Kamath, Aparna R Pai, Prasanna Kumar Reddy Gayam, Ekta Rati, Shivani Karnik, Alex Joseph, Angel Treasa Alex. Functionalization of Gold Nanoparticles with Monosaccharide Mannose. Research Journal of Pharmacy and Technology. 2021; 14(12):6281-4. doi: 10.52711/0974-360X.2021.01086

Cite(Electronic):
Sambit Dash, Pragna Rao, Ullas Kamath, Aparna R Pai, Prasanna Kumar Reddy Gayam, Ekta Rati, Shivani Karnik, Alex Joseph, Angel Treasa Alex. Functionalization of Gold Nanoparticles with Monosaccharide Mannose. Research Journal of Pharmacy and Technology. 2021; 14(12):6281-4. doi: 10.52711/0974-360X.2021.01086   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-12-16


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