Author(s): Tan LF, Mogana R, Sasikala Chinnappan, Venkatalakshmi R, Yap VL


DOI: 10.52711/0974-360X.2021.01061   

Address: Tan LF1, Mogana R1*, Sasikala Chinnappan1, Venkatalakshmi R2, Yap VL1
1Faculty of Pharmaceutical Sciences, No:1, Jalan Menara Gading, UCSI University (South Campus), Taman Connaught, Cheras, 56000, Kuala Lumpur, Malaysia.
2Department of Dosage Form Design, School of Pharmacy, MAHSA University, Bandar Saujana Putra, 42610 Jenjarom Selangor, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 11,     Year - 2021

Hyperpigmentation disorders caused by excessive melanin synthesis may significantly affect the psychosocial aspect of an individual. Being the current gold standard used for the treatment of hyperpigmentation disorders, hydroquinone is associated with several adverse effects including skin irritation, contact dermatitis, mutagenic to mammalian cells, cytotoxic to melanocytes as well as exogenous ochronosis in darker-complexioned individuals. Botanically derived agents have received increased attention in treating hyperpigmentation as they are perceived to be milder, safer, healthier and more cost-effective. Several herbs, plant extracts and phytochemicals with multitude mechanisms of action have been reported to be effective depigmenting agents with milder side effects. Some of the agents were studied in combination and their hypopigmentation effects may be resulting from synergistic effects of the various components. Mechanisms involved in depigmentation include tyrosinase inhibition, inhibition of a-melanocyte-stimulating hormone-induced melanogenesis and antioxidant properties. Use of plant-derived agents for the treatment of hyperpigmentation disorders is promising with the need for more rigorous clinical studies to support the use of these agents. This review summarizes the use of various plants and bioactive constituents and their effectiveness in the control of pigmentation.

Cite this article:
Tan LF, Mogana R, Sasikala Chinnappan, Venkatalakshmi R, Yap VL. Various Plants and Bioactive Constituents for Pigmentation Control: A Review. Research Journal of Pharmacy and Technology. 2021; 14(11):6106-2. doi: 10.52711/0974-360X.2021.01061

Tan LF, Mogana R, Sasikala Chinnappan, Venkatalakshmi R, Yap VL. Various Plants and Bioactive Constituents for Pigmentation Control: A Review. Research Journal of Pharmacy and Technology. 2021; 14(11):6106-2. doi: 10.52711/0974-360X.2021.01061   Available on:

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