Author(s):
Rutuja M. Sanap, Sarika R. Wavhale, Vaibhavi V. Kunjir, Rajkumar V. Shete
Email(s):
rutujasanap2311@gmail.com
DOI:
10.52711/0974-360X.2021.01051 
Address:
Rutuja M. Sanap1*, Sarika R. Wavhale1, Vaibhavi V. Kunjir1, Rajkumar V. Shete2
1Department of Pharmaceutical Quality Assurance, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist- Pune (M.S.) India.
2Department of Pharmacology,Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune (M.S.) India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
A simple, sensitive and accurate UV- spectrophotometric absorption correction method has been developed for simultaneous determination of Telmisartan, Amlodipine and Chlorthalidone in combined tablet dosage form. Analytical method development and validation plays important role in the discovery manufacture of pharmaceuticals and development. In this paper, absorption correction method is used for multi-component analysis. The wavelengths selected for the analysis were 311nm for Telmisartan, 228nm for Chlorthalidone and 253nm for Amlodipine. Beer’s law obeyed the concentration range of 2-10 µg /ml, 2-10 µg /ml and 5-25 µg/ ml for Telmisartan, Amlodipine and Chlorthalidone. Methanol is used as a solvent. The accuracy of the method was assessed by recovery studies and was found between the range of 100% to 110% for Telmisartan, 85% to 110% for Amlodipine and 85% to 105% Chlorthalidone. The % RSD value was found to be less than 2. Thus, the method was simple, precise, economic, rapid, accurate and can be successfully applied for simultaneous determination of Telmisartan, Amlodipine and Chlorthalidone in combined tablet dosage form.
Cite this article:
Rutuja M. Sanap, Sarika R. Wavhale, Vaibhavi V. Kunjir, Rajkumar V. Shete. Analytical Method Development and Validation for Telmisartan, Chlorthalidone and Amlodipine by UV- Spectroscopic Method. Research Journal of Pharmacy and Technology. 2021; 14(11):6049-4. doi: 10.52711/0974-360X.2021.01051
Cite(Electronic):
Rutuja M. Sanap, Sarika R. Wavhale, Vaibhavi V. Kunjir, Rajkumar V. Shete. Analytical Method Development and Validation for Telmisartan, Chlorthalidone and Amlodipine by UV- Spectroscopic Method. Research Journal of Pharmacy and Technology. 2021; 14(11):6049-4. doi: 10.52711/0974-360X.2021.01051 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-76
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