Author(s):
Seema Saini, Rajeev Garg
Email(s):
ughraseema84@gmail.com
DOI:
10.52711/0974-360X.2021.01016 
Address:
Seema Saini1,2*, Dr. Rajeev Garg3
1Department of Pharmaceutics, Rayat Institute of Pharmacy, Railmajra, S. B. S. Nagar, Punjab, India.
2IKG Punjab Technical University Jalandhar, Punjab, India.
3Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
The stability study is a critical parameter to be evaluated in a pharmaceutical product development cycle. A pharmaceutical scientist pays a great deal of heed in testing a product stability. The present research work focused on conducting stability study of fast disintegrating tablet batch of Nisoldipine (NFDT). The various parameters evaluated were weight, hardness, friability, disintegration time, drug content and % drug released. The stability study of optimized fast disintegrating tablet batch NFDT was performed according to ICH guidelines. For the study plan, fast disintegrating tablet batch was placed in a wide mouth air tight containers, which were charged into the stability chamber. The temperature was adjusted at 40°C ± 2°C and relative humidity of 75% ± 5%. The study period was of 6 months. The fast disintegrating tablet batch NFDT did not showed any significant difference in weight, hardness, % friability and disintegration time. The drug content was also reported to be in limits of acceptance. The % drug released at various time intervals was insignificantly changed during its storage period. Hence, the prepared tablets were stable during their storage period.
Cite this article:
Seema Saini, Rajeev Garg. Stability Study of fast Disintegrating tablets of Nisoldipine as per ICH Guidelines. Research Journal of Pharmacy and Technology. 2021; 14(11):5843-4. doi: 10.52711/0974-360X.2021.01016
Cite(Electronic):
Seema Saini, Rajeev Garg. Stability Study of fast Disintegrating tablets of Nisoldipine as per ICH Guidelines. Research Journal of Pharmacy and Technology. 2021; 14(11):5843-4. doi: 10.52711/0974-360X.2021.01016 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-41
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