Author(s):
Kiran C. Mahajan, Smita S. Pimple, Hemant A. Deokule
Email(s):
kirancmahajan@gmail.com
DOI:
10.52711/0974-360X.2021.01014 
Address:
Kiran C. Mahajan1*, Dr. Smita S. Pimple2, Hemant A. Deokule3
Department of Pharmaceutics, Progressive Education Society’s Modern College of Pharmacy, Nigdi-411044, Dist.-Pune, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
The present study aims to develop and optimize a self-emulsifying drug delivery system for paediatric patients to improve the oral bioavailability of the anthelmintic drug, Praziquantel (PZQ) and to perform it’s in-vitro dissolution study. The solubility of PZQ was estimated in various vehicles to select proper component combination. Capmul MCM (oil), Cremophore RH40 (surfactant) and PEG400 (co-surfactant) were employed to construct pseudo-ternary phase diagrams. Eight formulations composed of Capmul MCM, at Smix ratios (1:1, 2:1 & 3:1) were selected. The optimized formulation F7 has a mean globule size 14.73 nm with a negative zeta potential -44.43 mV. The results indicated that PZQ loaded SEDDS, showed enhanced solubilization and nanosizing potential to improve the absorption of the drug.
Cite this article:
Kiran C. Mahajan, Smita S. Pimple, Hemant A. Deokule. Formulation and Optimization of Self Emulsifying Drug Delivery System For Effective Anthelmintic Therapy. Research Journal of Pharmacy and Technology. 2021; 14(11):5831-7. doi: 10.52711/0974-360X.2021.01014
Cite(Electronic):
Kiran C. Mahajan, Smita S. Pimple, Hemant A. Deokule. Formulation and Optimization of Self Emulsifying Drug Delivery System For Effective Anthelmintic Therapy. Research Journal of Pharmacy and Technology. 2021; 14(11):5831-7. doi: 10.52711/0974-360X.2021.01014 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-39
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