Author(s):
Pooja Kamra, Mahaveer Singh, Hardarshan Singh Lamba, Birendra Srivastava
Email(s):
pooja_kamra125@rediffmail.com
DOI:
10.52711/0974-360X.2021.01012 
Address:
Pooja Kamra1,2, Mahaveer Singh3, Hardarshan Singh Lamba4, Birendra Srivastava3
1Research Scholar, School of Pharmaceutical Sciences, Jagatpura, Jaipur National University, Jaipur 302017, India.
2Department of Pharmacology, H.R. Institute of Pharmacy, Morta, Ghaziabad 201003, Uttar Pradesh, India.
3School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur 302017, Rajasthan, India.
4Department of Pharmacy, H.R. Institute of Pharmacy, Morta, Ghaziabad 201003, Uttar Pradesh, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
The present study aimed to evaluate the hepatoprotective potential of methanolic whole plant extract of Persicaria hydropiper in carbon tetrachloride (CCl4) induced hepatotoxicity model. Hepatotoxicity was induced in rats by intraperitoneal administration of carbon tetrachloride (CCl4) for seven days. The extract was thereafter administered at two different doses of 200 mg/kg and 400 mg/kg body weight for next seven days. Silymarin was used as a reference standard. The extract revealed hepatoprotective activity in dose dependent manner. The dose of 400 mg/kg exhibited maximum hepatoprotective ability as apparent from several evaluation parameters including liver function profile, bilirubin, antioxidant enzymes as well as histopathological investigation which was comparable to the standard drug Silymarin respectively. These findings sustenance the use of the extract as an adjuvant with existing therapy for treatment of liver ailments.
Cite this article:
Pooja Kamra, Mahaveer Singh, Hardarshan Singh Lamba, Birendra Srivastava. Evaluation of Hepatoprotective activity of Methanol extract of Persicaria hydropiper: An in vivo screening. Research Journal of Pharmacy and Technology. 2021; 14(11):5819-4. doi: 10.52711/0974-360X.2021.01012
Cite(Electronic):
Pooja Kamra, Mahaveer Singh, Hardarshan Singh Lamba, Birendra Srivastava. Evaluation of Hepatoprotective activity of Methanol extract of Persicaria hydropiper: An in vivo screening. Research Journal of Pharmacy and Technology. 2021; 14(11):5819-4. doi: 10.52711/0974-360X.2021.01012 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-37
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