Author(s):
Saba Jasim Hamdan, Khudair J. Al-Rawaq, Ali Abdul Razaq
Email(s):
zaidattar@kmc.uobaghdad.edu.iq , zaidattar77@gmail.com
DOI:
10.52711/0974-360X.2021.00997
Address:
Saba Jasim Hamdan1, Khudair J. Al-Rawaq2, Ali Abdul Razaq3
1Lecturer, Dept. of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
2,3Dept. of Radiation oncology, College of Medicine, University of Baghdad, Baghdad, Iraq.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
Background: Radiation therapy reported to be an effective in palliating pain. Objective: To describe roles of palliative radiotherapy in controlling pain in metastatic cancerous patients, and evaluation of radio-therapy doses in pain management. Methods: A prospective observational study carried out at the Baghdad Radiotherapy and Nuclear Medicine Center/Baghdad Medical City Complex, Baghdad, Iraq, from 1st of December 2018 to 30th of May 2019. 88 Patients, were included. Patients were assessed before applying radiotherapy, and at the end of treatment. Pain scoring used from 0 to 10. Kaplan Meier survival curve used. Result: The mean±SD of age was 55.44±11.1 years, and the most frequent age group was 41-50years as 37(42.1%). Breast cancer come in 1st rank cases studied in our research as 35(39.8%). 42(47.7%) of patients received radio-therapy on metastatic spine vertebral lesions. Sharp pain, frequent pain, pain at night were the commonest. Before treatment, the most common scoring was (8) in 33(37.5%) patients, while after palliative radio-therapy the scoring shift downward. Radio-therapy dose of 1200 cGy improved overall survival of patients in this study to 21.5 weeks (95%CI= 20.2-22.8). Conclusion: Radiotherapy is effective in palliative therapy. A dose of 1200 cGy improved overall survival of patients in this study to 21.5 weeks.
Cite this article:
Saba Jasim Hamdan, Khudair J. Al-Rawaq, Ali Abdul Razaq. Effect of Palliative Radiotherapy in controlling pain of Malignancy. Research Journal of Pharmacy and Technology. 2021; 14(11):5733-8. doi: 10.52711/0974-360X.2021.00997
Cite(Electronic):
Saba Jasim Hamdan, Khudair J. Al-Rawaq, Ali Abdul Razaq. Effect of Palliative Radiotherapy in controlling pain of Malignancy. Research Journal of Pharmacy and Technology. 2021; 14(11):5733-8. doi: 10.52711/0974-360X.2021.00997 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-22
REFERENCES:
1. Hansen EK, Roach M. Handbook of Evidence-Based Radiation Oncology: Springer International Publishing; 2018.
2. Vijayalakshmi DT, Asha K, Mounika BU, Babu KN. An Evaluation of quality of life in patients on concurrent Chemo radiotherapy with Cisplatin in Head and Neck Cancer-A Prospective Observational Study. Asian Journal of Pharmaceutical Research. 2018; 8(1): 21-31.
3. Louise Hanna , Tom Crosby , Macbeth F. Practical Clinical Oncology 2nd Edition, Kindle Edition: Cambridge University Press; 2 edition 2015.
4. Donovan MI. Pain: Clinical manual for nursing practice: By Margo McCaffery and Alexandra Beebe Published by the C.V. Mosby Company, St. Louis, Missouri 1989, 353 pages, $24.95 paper. Journal of Pain and Symptom Management. 1990; 5(5): 338-9.
5. Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain. 2019; 160(1): 19-27.
6. Adams MP, Holland LN, Urban CQ. Pharnacology for nurses. A Pathophysiologic approach: Pearson, USA. ; 2011.
7. American Pain F. Breakthrough cancer pain: mending the break in the continuum of care. Journal of pain & palliative care pharmacotherapy. 2011; 25(3): 252-64.
8. Fitzgibbon DR, Loeser JD. Cancer Pain: Wolters Kluwer Health; 2012. 464 p.
9. Lutz S, Korytko T, Nguyen J, Khan L, Chow E, Corn B. Palliative radiotherapy: when is it worth it and when is it not? Cancer journal (Sudbury, Mass). 2010; 16(5): 473-82.
10. Hartsell WF, Scott CB, Bruner DW, Scarantino CW, Ivker RA, Roach M, III, et al. Randomized Trial of Short- Versus Long-Course Radiotherapy for Palliation of Painful Bone Metastases. JNCI: Journal of the National Cancer Institute. 2005; 97(11): 798-804.
11. Tong D, Gillick L, Hendrickson FR. The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology Group. Cancer. 1982;50(5):893-9.
12. Blitzer PH. Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer. 1985;55(7):1468-72.
13. Brundha M, Pathmashri V, Sundari S. Quantitative Changes of Red Blood cells in Cancer Patients under Palliative Radiotherapy-A Retrospective Study. Research Journal of Pharmacy and Technology. 2019;12(2):687-92.
14. Burke; KM, LeMone; P, Mohn-Brown; E, Eby L. Medical-Surgical Nursing Care 2014. 1440 p.
15. Langley RE, Stephens RJ, Nankivell M, Pugh C, Moore B, Navani N, et al. Interim data from the Medical Research Council QUARTZ Trial: does whole brain radiotherapy affect the survival and quality of life of patients with brain metastases from non-small cell lung cancer? Clinical oncology (Royal College of Radiologists (Great Britain)). 2013; 25(3): e23-30.
16. Clinical Practice Guidelines in Oncology. updated Version.2 Plymouth Meeting: National Comprehensive Cancer Network; 2019 [Available from: https://www.nccn.org/professionals/ physician_gls/default.aspx.
17. Ratanatharathorn V, Powers WE, Moss WT, Perez CA. Bone metastasis: review and critical analysis of random allocation trials of local field treatment. International journal of radiation oncology, biology, physics. 1999; 44(1): 1-18.
18. Sande TA, Ruenes R, Lund JA, Bruland OS, Hornslien K, Bremnes R, et al. Long-term follow-up of cancer patients receiving radiotherapy for bone metastases: results from a randomised multicentre trial. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology. 2009; 91(2): 261-6.
19. Adams; MP, Holland; N, Urban C. Pharmacology for Nurses: A Pathophysiologic Approach: Pearson; 2016.
20. Soffietti R, Kocher M, Abacioglu UM, Villa S, Fauchon F, Baumert BG, et al. A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life results. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2013; 31(1): 65-72.
21. Howell DD, James JL, Hartsell WF, Suntharalingam M, Machtay M, Suh JH, et al. Single-fraction radiotherapy versus multifraction radiotherapy for palliation of painful vertebral bone metastases-equivalent efficacy, less toxicity, more convenient: a subset analysis of Radiation Therapy Oncology Group trial 97-14. Cancer. 2013; 119(4): 888-96.