S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna
S. Sivaprasad*, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna
MNR College of Pharmacy, MNR Higher Education and Research Academy Campus, Fasalwadi (V), Sangareddy, Telangana, India, 502294.
Volume - 14,
Issue - 11,
Year - 2021
The main objective of the present study was to design a controlled release dosage form for an oral anti diabetic drug i.e. repaglinide employing polymers like eudragit s- 100. One of the other objective of this present study was to increase the biological half-life the drug by formulating into microspheres. The microspheres of repaglinide were prepared by solvent evaporation method by using eudragit s-100 and ethyl cellulose as polymers with different concentrations. Formulations (F1-F10) were prepared and evaluated for various micrometric properties and it was observed that though all the formulations were exhibited good flow properties, The F5 formulation exhibits higher in- vitro buoyancy time and entrapment efficiency which is considered for in- vitro and mucoadhesive studies. The FTIR results reveal that there was no interaction between the drug and the excipients. The in- vitro release profiles of F1-F5 indicated that all formulations showed controlled release over an extended period, with acceptable release kinetics. Among the all formulations F5 were considered as a promising candidate for sustain release of repaglinide.
Cite this article:
S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna. Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11):5673-9. doi: 10.52711/0974-360X.2021.00986
S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna. Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11):5673-9. doi: 10.52711/0974-360X.2021.00986 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-11
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