Author(s):
S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna
Email(s):
sagiliprasad2003@gmail.com
DOI:
10.52711/0974-360X.2021.00986 
Address:
S. Sivaprasad*, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna
MNR College of Pharmacy, MNR Higher Education and Research Academy Campus, Fasalwadi (V), Sangareddy, Telangana, India, 502294.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
The main objective of the present study was to design a controlled release dosage form for an oral anti diabetic drug i.e. repaglinide employing polymers like eudragit s- 100. One of the other objective of this present study was to increase the biological half-life the drug by formulating into microspheres. The microspheres of repaglinide were prepared by solvent evaporation method by using eudragit s-100 and ethyl cellulose as polymers with different concentrations. Formulations (F1-F10) were prepared and evaluated for various micrometric properties and it was observed that though all the formulations were exhibited good flow properties, The F5 formulation exhibits higher in- vitro buoyancy time and entrapment efficiency which is considered for in- vitro and mucoadhesive studies. The FTIR results reveal that there was no interaction between the drug and the excipients. The in- vitro release profiles of F1-F5 indicated that all formulations showed controlled release over an extended period, with acceptable release kinetics. Among the all formulations F5 were considered as a promising candidate for sustain release of repaglinide.
Cite this article:
S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna. Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11):5673-9. doi: 10.52711/0974-360X.2021.00986
Cite(Electronic):
S. Sivaprasad, V. Alagarsamy, M. Prathibha Bharathi, P.V. Murali Krishna, K. Sandeeep Kanna. Formulation and Evaluation of Mucoadhesive Floating Microspheres of Repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11):5673-9. doi: 10.52711/0974-360X.2021.00986 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-11-11
REFERENCES:
1. Banker GS, Anderson NR. Tablets: The Theory and Practice of Industrial Pharmacy. 3rd. Bombay: Varghese Pub. House; 2003.
2. Chein YW. Novel Drug Delivery Systems. 2nd Ed. New York: Marcel Dekker. Inc.1992.
3. Aulton ME. Pharmaceutics: The Science of Dosage Form Design. 2nd ed. Livingstone C. Elsevier Science Ltd; 2002.
4. Yeole PG, Khan S, Patel VF. Floating Drug Delivery Systems: Need and Development. Indian J Pharm Sci 2005; 67(3): 265-272.
5. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery system. A review. AAPS Pharm Sci Tech. 2005; 6(3): 372-390.
6. Chowdary KPR, Srinivas L. Mucoadhesive drug delivery systems. A review of current status. Indian Drugs. 2000; 3(7): 400-403.
7. Pradip P Gade, Mohd. Majid Iqbal, K Sreenivasa Rao. Development and In-Vitro Evaluation of Gastro-Retentive Floating Drug Delivery System of Cefixime Trihydrate. Research Journal of Pharmacy and Technology. 2009; 2(3): July-sept.2009; 507-512.
8. Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi. Formulation and Evaluation of Floating Drug Delivery System Using Losartan. Research Journal of Pharmacy and Technology. 2015; 8(2):145-153.
9. S. J. Daharwal, S Prakash Rao, Vijay Kumar Singh, Kunal Chandrakar, Veena D. Singh. Formulation and Characterization of Metformin HCl Sustained Release Matrix Tablet by using Cassia tora Mucilage. Research Journal of Pharmacy and Technology. 2015; 8(7): 871-879.
10. Pallavi M. Pawashe, Shital Kumar S. Patil, Nilofar S. Naikwade. Prochlorperazine Maleate Loaded Sustained Release Floating Microspheres prepared by Ionotropic Gelation Technique: Morphology and Release Characteristics. Research Journal of Pharmacy and Technology. 2019; 12(8):3866-3872.
11. Singh BN, Kwon HK. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release 2000; 63:235–249.
12. Yuveraj Singh T, Naruk PS, Ojha GR. Development and evaluation of floating microspheres of Verpamil Hydrochloride. Brazilian Journal of Pharmaceutical Sciences. 2007; 43(4):529-534.
13. Jain AK, Jain CP, Tanwar YS, Naruka, PS. Formulation characterization and in vitro evaluation of floating microspheres of Famotidine as a gastro retentive dosage form. Asian Journal of Pharmaceutics. 2009; 3(3): 222-226.
14. Wattamwar Mayur M, Ratnaparkhi Mukesh P, Kutmalge M.D, Jadhav A. N. Formulation and in vitro evaluation of mucoadhesive microspheres of pioglitazon hydrochloride. Asian Pacific Journal of Health Sciences. 2014; 1(3):177-192.
15. Satyabrata Bhanja, M. Sudhakar, V. Neelima, B.B. Panigrahi, Harekrishna Roy. Development and Evaluation of Mucoadhesive Microspheres of Irbesartan. International Journal of Pharma Research and Health Sciences. 2013; 1(3): 8-17.
16. Altaf Bhai M Sipai, Vandana Yadav, Prasanth. Formulation and evaluation of mucoadhesive microspheres of metformin hydrochloride. Indian Journal of Pharmaceutical Science and Research. 2014; 4(2): 94-101.