Author(s): D. Gnanasekaran, R. Gandhimathi

Email(s): drgmathipharm2017@gmail.com

DOI: 10.52711/0974-360X.2021.00975   

Address: D. Gnanasekaran, Dr. R. Gandhimathi*
Department of Pharmaceutical Chemistry and Analysis, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
A review is presented on different analytical techniques used for quantitative analysis of novel Dipeptidyl peptidase-4 inhibitor (DPP-4) - Vildagliptin. Endeavours have been made to examine all the pertinent references to the degree conceivable. The review discusses the pros and cons of the cited analytical techniques, which will aid to give understand into the methods used for determination of Vildagliptin, from clinical isolates and from its pharmaceutical dosage forms. The major focus of this review is the basic as well as advanced analytical techniques established for determination of Vildagliptin. The procedures outlined here have been exhibited to be helpful for assessment of Vildagliptin and may discover application in dissecting other related properties.


Cite this article:
D. Gnanasekaran, R. Gandhimathi. Quantification Of Novel Dpp4 Inhibitor - Vildagliptin By Spectrophotometric And Chromatographic Techniques: Brief Review. Research Journal of Pharmacy and Technology 2021; 14(10):5603-0. doi: 10.52711/0974-360X.2021.00975

Cite(Electronic):
D. Gnanasekaran, R. Gandhimathi. Quantification Of Novel Dpp4 Inhibitor - Vildagliptin By Spectrophotometric And Chromatographic Techniques: Brief Review. Research Journal of Pharmacy and Technology 2021; 14(10):5603-0. doi: 10.52711/0974-360X.2021.00975   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-93


REFERENCES:
1.    McIntosh CH, Demuth HU, Pospisilik JA and Pederson R. Dipeptidyl peptidase IV inhibitors. How do they work as new antidiabetic agents. Regul Pept. 2005; 128: 159-165.
2.    Weber AE. Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. J Med Chem. 2004; 47: 4135-4141.
3.    Lauster CD, McKaveney TP and Muench SV. Vildagliptin: a novel oral therapy for type 2 diabetes mellitus. Am J Health Syst Pharm. 2007; 64: 1265-1273.
4.    He H, Tran P and Yin H. Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans. Drug Metab Dispos. 2009; 37: 536-544.
5.    Asma Afroz, Tasnuva Haque, Md. Mesbah Uddin Talukder and S. M. Ashraful Islam. Spectrophotometric Estimation of Rosuvastatin Calcium and Glimepiride in Tablet Dosage Form. Asian J. Pharm. Ana. 2011; 1(4): 74-78
6.    Sonali D. Rathod, P.M. Patil, S. B. Jadhav and P.D. Chaudhari. UV Spectrophotometric Simultaneous Determination of Metformine Hydrochloride and Pioglitazone Hydrochloride in Combined Dosage Form. Asian J. Pharm. Ana. 2012; 2(1): 05-09.
7.    N Harikrishnan, U Muralikrishna, Basha Shaik, Vishal Bhavsar, Manjusha V and V Ranjith Kumar. Development and Validation of UV Spectrophotometric Method of Glibenclamide (Glyburide) in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 2010; 3(2): 316-318.
8.    K. Vijaya Sri, M. Anusha, S. Ravinder Reddy. A Rapid RP-HPLC Method development and Validation for the Analysis of Linagliptinin Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Ana. 2015; 5(1): 16-20
9.    Sathish Kumar Konidala, Pampana V V Suresh Babu, Ranj, K S D Ranjitha. RP-HPLC Method Development and Validation for the Simultaneous Estimation of Sitagliptin and Simvastatin in Pharmaceutical Formulation. Asian J. Pharm. Ana. 2016; 6(2): 68-76.
10.    Rahul K. Godge, Ganesh S. Shinde, Shraddha Joshi.Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC. Research J. Science and Tech. 2019; 11(1): 59-63.
11.    Nachiket S. Dighe, Ganesh S. Shinde, Jyoti. J. Vikhe. Simultaneous Estimation, Validation and Force Degradation Study of Metformin Hydrochloride and Empagliflozin by RP-HPLC Method. Research J. Science and Tech. 2019; 11(2): 135-147
12.    D. Narmada, P.V. Murali Krishna, Shaik Mohammad Yusuf, B. Ranganayakulu, K. Uday Praveen and P. Raja Abhilash. RP-HPLC method development and validation for estimation of Glibenclamide in tablet dosage form. Asian J. Pharm. Ana. 2014; 4(3): 125-128
13.    El-Bagary RI, El-Kady EF and Ayoub BM. Spectrophotometric methods for the determination of sitagliptin and vildagliptin in bulk and dosage forms. Int J Biomed Sci. 2011; 7: 55–61.
14.    Samer Housheh, Hanan Mohammad and Youssef Alahmad. Spectrophotometric Method for the Determination of Vildagliptin in Bulk and Pharmaceutical Dosage Forms. Int J Pharm Sci Rev Res. 2019; 17: 117-120.
15.    Marwa S. Moneeb. Spectrophotometric and spectrofluorimetric methods for the determination of saxagliptin and vildagliptin in bulk and pharmaceutical preparations. Bulletin of Faculty of Pharmacy. Cairo University. 2013; 51: 139–150.
16.    Sujan Banik, Palash Karmakar and Md. Anowar Hossain Miah. Development and validation of a UV-spectrophotometric method for determination of vildagliptin and linagliptin in bulk and pharmaceutical dosage forms. Bangladesh Pharmaceutical Journal. 2015; 18(2): 163-168.
17.    P. V. Prasad, K. Divya, M.V. Ramana, A. Krishnaveni, J. Vinay and M. Mahadeswar. Analytical method development and validation for the estimation of vildagliptin in bulk and its dosage form using UV spectrophotometer. IAJPR. 2017; 7(12): 2231-6876.
18.    Baokar Shrikrishna, Mulgund S. V and Ranpise N. S. Simultaneous spectrophotometric estimation of vildagliptin and metformin in bulk and tablet dosage form. Der Pharma Chemica. 2013; 5(1): 24-27
19.    Omar Abdel-Aziz, Miriam F. Ayad and Mariam M. Tadros. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments. Spectrochimica Acta. 2015; S1386-1425(14): 01890-3.
20.    B. Amani, G. Raveendra Babu and NVL Sirisha Mulukuri. A novel spectroscopic method for the simultaneous determination of pregabilin and vildagliptin in synthetic mixture. International research journal of pharmacy. 2017; 8(10): 153-156.
21.    Karajgi Santosh Raveendra, Shahid Momin Gaffar and Navanath V. Kalyane. First derivative spectrophotometric simultaneous determination of vildagliptin and metformin in tablet formulations. Pharmacophore. 2016; 7(2): 109-117.
22.    Dr. Safila Naveed, Hina Rehman, Fatima Qamar and Syeda Zainab. Method development and validation of Vildagliptin using UV spectrophotometer. International Journal of Pharma Sciences and Research. 2014; 5(10): 714-717.
23.    Usharani Gundala, Chandra Shekar Bhuvanagiri and Devanna Nayakanti. Simultaneous estimation of vildagliptin and metformin in bulk and pharmaceutical formulations by UV spectrophotometry. Am. J. PharmTech Res. 2013; 3(1): 338-345.
24.    Amanda T. Barden, Bruna L. Piccoli, Nadia M. Volpato and Martin Steppe. Second-order derivative UV spectrophotometric and RP-HPLC methods for the analysis of vildagliptin and application for dissolution study. Drug Analytical Research. 2018; 02(1): 46-53.
25.    Hanumantha Rao K, Lakshmana Rao A and Chandra Sekhar KB. Development and validation of HPLC method for the estimation of vildagliptin in pharmaceutical dosage form. International journal of pharmaceutical, chemical and biological sciences. 2014; 4(2): 361-366.
26.    Aparajita Malakar, Bishwajit Bokshi and Dilruba Nasrin. Development and validation of a RP-HPLC method for estimation of vildagliptin from tablet dosage form. International Journal of Pharmaceutical and Life Sciences. 2012; 1(1): 1-8.
27.    K. Manohar, B. Thangabalan and S. Manohar Babu. Method development and validation for the simultaneous estimation of vildagliptin and metformin in tablet dosage form by RP-HPLC. International Journal of Research in Pharmaceutical and Nano Sciences. 2014; 3(2): 80-87.
28.    B.Santhosha, A.Ravindranath and Ch.Sundari. Validated method for the simultaneous estimation of metformin hydrochloride and vildagliptin by RP-HPLC in bulk and the pharmaceutical dosage form. International Research Journal of Pharmaceutical and Applied Sciences. 2012; 2(3): 22-28.
29.    Satheeshkumar N, Pradeepkumar M, Shanthikumar S and Rao VJ. Development of validated stability indicating assay method for simultaneous estimation of metformin hydrochloride and vildagliptin by RP-HPLC. Available from: URL: https://pubmed.ncbi.nlm.nih.gov/24081820/2013/ 64(3).
30.    Ramesh Jayaprakash and Senthil Kumar Natesan. Stability indicating RP-HPLC method development and validation for the simultaneous determination of vildagliptin and metformin in pharmaceutical dosage form. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9(3): 150-157.
31.    Khushabu R. Patil, Tushar A. Deshmukh and Vijay R. Patil. Development and validation of HPLC method for the simultaneous estimation of vildagliptin and metformin in bulk and pharmaceutical dosage form. Available from: URL: https://scinapse.io/papers/2577146878/2015.
32.    Subhakar Nandipati, Krishna Reddy V and Ravindranadh Reddy T. Development and validation of a RP-HPLC method for simultaneous determination of vildagliptin and metformin in bulk and formulation dosage form. International Research Journal of Pharmaceutical and Applied Sciences. 2012; 2(3): 44-50.
33.    PSR CH, NP Varme D, Lakshmana Rao A and Dinda SC. Simultaneous determination of metformin and vildagliptin in solid dosage form by a stability indicating RP-HPLC method. International Research Journal of Pharmacy. 2013; 4(1): 122-128.
34.    W. Abu Dayyih, M. Hamad, E. Mallah, A. Abu Dayyih, R. Awad, Z. Zakaria and T. Arafat. Method development and validation of vildagliptin and metformin hcl in pharmaceutical dosage form by RP-HPLC. International Journal of Pharmaceutical Sciences and Research. 2018; 9(7): 2965-2972.
35.    Meetali M. Chaphekar and Purnima D. Hamrapurkar. Development and validation of RP-HPLC assay method for vildagliptin using QbD approach and its application to forced degradation studies. International Journal of Pharmaceutical Sciences and Drug Research. 2016; 8(3): 157-165.
36.    Pragati Ranjan Satpathy, V. Mohan Goud, Bhoga Bhagya, JVC. Sharma and N. Shyamala. Development and validation of a RP-HPLC method for the assay of vildagliptin. World Journal of Pharmacy and Pharmaceutical Sciences. 2014; 3(2): 2303-2310.
37.    Mohammed M. Amin, Salah A. Abdel-Aziz1, Samia M. Mostafa and Sobhy M. El-Adl. Optimization and validation of HPLC method for simultaneous determination of vildagliptin, pioglitazone hydrochloride and glimepiride in bulk and tablets. IOSR Journal of Pharmacy and Biological Sciences. 2017; 12(2): 18-27.
38.    Sai Lohit.Ch, Suman Pattanayak and T. Rama Rao. Development and validation of rp- hplc method for the simultaneous estimation of vildagliptin and metformin in tablet dosage form. American Journal of Pharmtech Research. 2014; 4(5): 138-145.
39.    Thangabalan Boovizhikannan and Vijayaraj Kumar Palanirajan. RP-HPLC determination of vildagliptin in pure and in tablet formulation. Journal of Pharmacy Research. 2013; 7: 113-116.
40.    Hitesh P. Inamdar, Ashok A. Mhaske and Shirish P. Sahastrabudhe. A revised RP-HPLC method for simultaneous determination of vildagliptin and pioglitazone hcl – application to commercially available drug products. International Journal of Pharmaceutical Sciences and Research. 2013; 4(2): 847-855.
41.    B. Mohammed Ishaq, Dr. K. Vanitha Prakash and Dr. G. Krishna Mohan. RP-HPLC method for simultaneous estimation of metformin and vildagliptin in bulk and its tablet formulation. Journal of Global Trends in Pharmaceutical Sciences. 2012; 3(3): 747-754.
42.    Shrikrishna B. Baokar, Sugandha V. Mulgund, Nisharani S. Ranpise. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Vildagliptin and Metformin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2013; 5(2): 95-98
43.    Atul R. Bendale, R. P. Singh and G. Vidyasagar. Development and validation stability indicating HPTLC method for determination of vildagliptin and metformin hydrochloride in the pharmaceutical dosage forms. International Journal of Applied Pharmaceutics. 2018; 10(1): 36-45.
44.    Eman I. El-Kimary, Dalia A. Hamdy, Sara S. Mourad and Magda A. Barary. HPTLC determination of three gliptins in binary mixtures with metformin. Journal of Chromatographic Science. 2016; 54(1): 79–87.
45.    Amanda Thomas Barden, Barbara Salamon, Elfrides Eva Sherman Schapoval and Martin Steppe. Stability-indicating RP-LC method for the determination of vildagliptin and mass spectrometry detection for a main degradation product. Journal of Chromatographic Science. 2012; 50: 426-432.
46.    Manal Mohamed Fouad. RP-UPLC method development and validation for simultaneous estimation of vildagliptin with metformin hydrochloride and ciprofloxacin hydrochloride with dexamethasone sodium phosphate. World Journal of Pharmaceutical Sciences. 2015; 3(9): 1755-1762.
47.    Sharifa Sultana, Uttom Kumar, Md. Shahadat Hossain, Dilshad Noor Lira and Abu Shara Shamsur Rouf. QbD approach for the development and validation of RP-UHPLC method for quantitation of vildagliptin. Dhaka University Journal of Pharmaceutical Sciences. 2017; 16(1): 107-117.
48.    A. B. Pharne, B. Santhakumari, A. S. Ghemud, H. K. Jain and M. J. Kulkarni. Bioanalytical method development and validation of vildagliptin a novel dipeptidyl peptidase iv inhibitor by rp-hplc method. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(3): 119-123.
49.    Mahesh Attimarad, Sree Harsha Nagaraja, Bandar E. Aldhubaib and Ahmed Al-Najjar. Development of a rapid reversed phase-high performance liquid chromatography method for simultaneous determination of metformin and vildagliptin in formulation and human plasma. Journal of Young Pharmacists. 2014; 6(4): 40-46.

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Justin Antony, Satadal Debroy, Chennu Manisha, Peet Thomas, Victoria Jeyarani, Tenzin Choephel

DOI: 10.5958/0974-360X.2019.00367.6         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.

DOI: 10.5958/0974-360X.2020.00614.9         Access: Open Access Read More

Author(s): Suha Alnaeb, Youssef Alahmad, Saleh Trefi

DOI: 10.5958/0974-360X.2019.01035.7         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Bahubali N. Patil, Vamshi Krishna Tippavajhala, Girish Pai K

DOI: 10.5958/0974-360X.2019.00140.9         Access: Open Access Read More

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags